Cited by 236Diabetes Management and EducationDiabetes, Cardiovascular Risks, and LipoproteinsCardiac Health and Mental Health

Depression and risk for diabetes: a meta-analysis

Yu, Min, Zhang, Xingliang, Lu, Feng, Fang, Le·2015·Canadian Journal of Diabetes

Abstract

Objective Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes. Methods We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test. Results As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47). Conclusions Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.

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Crossref · 10.1016/j.jcjd.2014.11.006

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Authors
Yu, M., Zhang, X., Lu, F., & Fang, L.
Affiliations
  • Zhejiang Center for Disease Control and Prevention (CN)
  • Hangzhou Center for Disease Control and Prevention (CN)
Corresponding author
Fang, Le
Venue
Canadian Journal of Diabetes
Publisher
Elsevier BV
Published
2015-08
Volume
39
Issue
4
Pages
266-272
ISSN
1499-2671 (ISSN-L)
OpenAlex
W1995900788
Cited by
236
References
64
Citations by year
2026: 12 · 2025: 17 · 2024: 41 · 2023: 31 · 2022: 28 · 2021: 25 · 2020: 25 · 2019: 22 · 2018: 16 · 2017: 7 · 2016: 7 · 2015: 5
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Locations
  • Canadian Journal of Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
Major Special Project of Science and Technology (2011C13032-1)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
depression, type 2 diabetes, diabetes risk, relative risk
MeSH terms
Cross-Sectional Studies, Depression, Diabetes Mellitus, Type 2, Humans, Risk Factors, Cohort Studies, Case-Control Studies

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