CoChat
Sign Up
Cited by 175

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

LDL Receptor–Related Protein-1

Gonias, Steven L., Campana, W. Marie·2014·The American Journal of Pathology
DOI 10.1016/j.ajpath.2013.08.029
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ajpath.2013.08.029

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Molecular models showing the organization of structural domains in LRP1 and the docking of a representative ligand to complement-like repeats in LRP1. A : The depicted domains in LRP1 are common to the LDL receptor family. Stars are present in the intracellular region of LRP1 to represent motifs that function as endocytosis signals and/or as docking sites for cell-signaling proteins including NPXY, YxxL, and dileucine. B : A representative LRP1 ligand, the 18-kDa receptorbinding domain of a 2-macroglobulin, which is a free-standing domain in the activated state of the protein, is shown in pink. Two lysine residues in a single a -helix, highlighted in blue, are essential for binding to LRP1. These lysine residues interact with acidic amino acids in the LRP1 complementlike repeats. The fourth and fi fth complement-like repeats in CCR2 are shown in orange, and the acidic amino acids in these domains are highlighted in black. The approximate positions of calcium are shown. EGF, epidermal growth factor.
Figure 1 Molecular models showing the organization of structural domains in LRP1 and the docking of a representative ligand to complement-like repeats in LRP1. A : The depicted domains in LRP1 are common to the LDL receptor family. Stars are present in the intracellular region of LRP1 to represent motifs that function as endocytosis signals and/or as docking sites for cell-signaling proteins including NPXY, YxxL, and dileucine. B : A representative LRP1 ligand, the 18-kDa receptorbinding domain of a 2-macroglobulin, which is a free-standing domain in the activated state of the protein, is shown in pink. Two lysine residues in a single a -helix, highlighted in blue, are essential for binding to LRP1. These lysine residues interact with acidic amino acids in the LRP1 complementlike repeats. The fourth and fi fth complement-like repeats in CCR2 are shown in orange, and the acidic amino acids in these domains are highlighted in black. The approximate positions of calcium are shown. EGF, epidermal growth factor.CC-BY-NC-ND · From the PDF
Figure 2 LRP1 interaction map generated using the Ingenuity IPA System. The map was limited to interactions involving the nervous system in infl ammatory disease and in the in fl ammatory response. Interactions are strati fi ed in relation to the location of the LRP1-interacting gene product relative to the cell. Interacting gene products include cytokines ( closed square ), growth factors ( broken square ), proteases ( horizontally elongated diamond ), other enzymes ( vertically elongated diamond ), proteins involved in transport ( trapezoid ), transmembrane receptors ( vertically elongated oval ), ion channel subunits ( broken vertically elongated rectangle ), kinases ( inverted triangle ), transcription regulators ( horizontally elongated oval ), and phosphatases ( triangle ). Other categories of gene products are shown as circles . Direct interactions are shown with a solid line and indirect interactions with a broken line. A solid line without an arrow implies a binding interaction. An arrowhead at the end of a broken line implies that one gene product acts on the other. A perpendicular bar implies an inhibitory interaction.
Figure 2 LRP1 interaction map generated using the Ingenuity IPA System. The map was limited to interactions involving the nervous system in infl ammatory disease and in the in fl ammatory response. Interactions are strati fi ed in relation to the location of the LRP1-interacting gene product relative to the cell. Interacting gene products include cytokines ( closed square ), growth factors ( broken square ), proteases ( horizontally elongated diamond ), other enzymes ( vertically elongated diamond ), proteins involved in transport ( trapezoid ), transmembrane receptors ( vertically elongated oval ), ion channel subunits ( broken vertically elongated rectangle ), kinases ( inverted triangle ), transcription regulators ( horizontally elongated oval ), and phosphatases ( triangle ). Other categories of gene products are shown as circles . Direct interactions are shown with a solid line and indirect interactions with a broken line. A solid line without an arrow implies a binding interaction. An arrowhead at the end of a broken line implies that one gene product acts on the other. A perpendicular bar implies an inhibitory interaction.CC-BY-NC-ND · From the PDF
Figure 3 IHC analysis to detect LRP1 in the nervous system. A : LRP1 immunostaining of mouse cerebral cortex. LRP1 was detected with a primary polyclonal antibody that detects the b -chain (Sigma-Aldrich, St. Louis, MO). Staining was conducted using a Ventana System (Tucson, AZ). B : A section of rat sciatic nerve distal to a crush injury site, which was recovered 3 days after nerve injury. LRP1 was detected using polyclonal antibody R2629. The section is counterstained with methylene green. Representative LRP1-immunopositive Schwann cells are marked with arrows . The asterisk marks a macrophage. Scale bars: 35 m m ( A ); 12 m m ( B ).
Figure 3 IHC analysis to detect LRP1 in the nervous system. A : LRP1 immunostaining of mouse cerebral cortex. LRP1 was detected with a primary polyclonal antibody that detects the b -chain (Sigma-Aldrich, St. Louis, MO). Staining was conducted using a Ventana System (Tucson, AZ). B : A section of rat sciatic nerve distal to a crush injury site, which was recovered 3 days after nerve injury. LRP1 was detected using polyclonal antibody R2629. The section is counterstained with methylene green. Representative LRP1-immunopositive Schwann cells are marked with arrows . The asterisk marks a macrophage. Scale bars: 35 m m ( A ); 12 m m ( B ).CC-BY-NC-ND · From the PDF

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 97

  1. Herz, 1988, Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor, EMBO J, 7, 4119, 10.1002/j.1460-2075.1988.tb03306.x · DOI
  2. Herz, 1990, Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment, EMBO J, 9, 1769, 10.1002/j.1460-2075.1990.tb08301.x · DOI
  3. Van Leuven, 1980, Primary amines inhibit recycling of alpha 2M receptors in fibroblasts, Cell, 20, 37, 10.1016/0092-8674(80)90232-9 · DOI
  4. Herz, 1990, Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver, J Biol Chem, 265, 21355, 10.1016/S0021-9258(17)45368-3 · DOI
  5. Wu, 2005, The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts, J Cell Biochem, 96, 1021, 10.1002/jcb.20596 · DOI
  6. Willingham, 1980, The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts, Cell, 21, 67, 10.1016/0092-8674(80)90115-4 · DOI
  7. Pan, 2004, Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier, J Cell Sci, 117, 5071, 10.1242/jcs.01381 · DOI
  8. Benchenane, 2005, Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process, Stroke, 36, 1065, 10.1161/01.STR.0000163050.39122.4f · DOI
  9. Strickland, 2002, Diverse roles for the LDL receptor family, Trends Endocrinol Metab, 13, 66, 10.1016/S1043-2760(01)00526-4 · DOI · Paper page
  10. Neels, 1999, The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties, J Biol Chem, 274, 31305, 10.1074/jbc.274.44.31305 · DOI · Paper page
  11. Li, 2000, The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein, J Biol Chem, 275, 17187, 10.1074/jbc.M000490200 · DOI
  12. Trommsdorff, 1998, Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein, J Biol Chem, 273, 33556, 10.1074/jbc.273.50.33556 · DOI · Paper page
  13. Loukinova, 2002, Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP): evidence for integrated co-receptor function between LRP and the PDGF, J Biol Chem, 277, 15499, 10.1074/jbc.M200427200 · DOI
  14. Kowal, 1989, Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins, Proc Natl Acad Sci U S A, 86, 5810, 10.1073/pnas.86.15.5810 · DOI
  15. Strickland, 1990, Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor, J Biol Chem, 265, 17401, 10.1016/S0021-9258(18)38172-9 · DOI · Paper page
  16. Arandjelovic, 2005, Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1, Arch Biochem Biophys, 438, 29, 10.1016/j.abb.2005.03.019 · DOI
  17. Gettins, 2012, A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein), Biochem J, 443, 65, 10.1042/BJ20111867 · DOI
  18. Gaultier, 2009, Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis, J Cell Sci, 122, 1155, 10.1242/jcs.040717 · DOI · Paper page
  19. Stiles, 2013, LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin, J Cell Sci, 126, 209, 10.1242/jcs.113191 · DOI
  20. Ogden, 2001, C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells, J Exp Med, 194, 781, 10.1084/jem.194.6.781 · DOI
  21. Gardai, 2003, By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation, Cell, 115, 13, 10.1016/S0092-8674(03)00758-X · DOI
  22. Fernandez-Castaneda, 2013, Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris, J Biol Chem, 288, 4538, 10.1074/jbc.M112.384693 · DOI · Paper page
  23. Lauber, 2004, Clearance of apoptotic cells: getting rid of the corpses, Mol Cell, 14, 277, 10.1016/S1097-2765(04)00237-0 · DOI
  24. Gonias, 2004, Low density lipoprotein receptor-related protein: regulation of the plasma membrane proteome, Thromb Haemost, 91, 1056, 10.1160/TH04-01-0023 · DOI
  25. Gaultier, 2010, LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome, J Proteome Res, 9, 6689, 10.1021/pr1008288 · DOI
  26. Ulery, 2000, Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP): evidence that LRP contributes to the pathogenesis of Alzheimer’s disease, J Biol Chem, 275, 7410, 10.1074/jbc.275.10.7410 · DOI · Paper page
  27. Pietrzik, 2004, FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein, J Neurosci, 24, 4259, 10.1523/JNEUROSCI.5451-03.2004 · DOI · Paper page
  28. May, 2004, Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice, Mol Cell Biol, 24, 8872, 10.1128/MCB.24.20.8872-8883.2004 · DOI · Paper page
  29. Gonias, 2011, Regulation of the urokinase receptor (uPAR) by LDL receptor-related protein-1 (LRP1), Curr Pharm Des, 17, 1962, 10.2174/138161211796718224 · DOI
  30. Warshawsky, 1994, The low density lipoprotein receptor-related protein mediates the cellular degradation of tissue factor pathway inhibitor, Proc Natl Acad Sci U S A, 91, 6664, 10.1073/pnas.91.14.6664 · DOI
  31. Herz, 1991, 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor, J Biol Chem, 266, 21232, 10.1016/S0021-9258(18)54845-6 · DOI · Paper page
  32. Basu, 2001, CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin, Immunity, 14, 303, 10.1016/S1074-7613(01)00111-X · DOI · Paper page
  33. Binder, 2004, Essential role of CD91 in re-presentation of gp96-chaperoned peptides, Proc Natl Acad Sci U S A, 101, 6128, 10.1073/pnas.0308180101 · DOI
  34. Chu, 1993, Receptor-mediated antigen delivery into macrophages: complexing antigen to alpha 2-macroglobulin enhances presentation to T cells, J Immunol, 150, 48, 10.4049/jimmunol.150.1.48 · DOI
  35. Capurro, 2012, LRP1 mediates Hedgehog-induced endocytosis of the GPC3-Hedgehog complex, J Cell Sci, 125, 3380
  36. Pi, 2012, LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis, Circ Res, 111, 564, 10.1161/CIRCRESAHA.112.274597 · DOI
  37. Boucher, 2003, LRP: role in vascular wall integrity and protection from atherosclerosis, Science, 300, 329, 10.1126/science.1082095 · DOI
  38. Newton, 2005, Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP): evidence for co-receptor function, J Biol Chem, 280, 27872, 10.1074/jbc.M505410200 · DOI
  39. Muratoglu, 2010, Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway, J Biol Chem, 285, 14308, 10.1074/jbc.M109.046672 · DOI
  40. Qiu, 2004, Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons, J Biol Chem, 279, 34948, 10.1074/jbc.M401055200 · DOI
  41. Hu, 2006, Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression, J Biol Chem, 281, 2120, 10.1074/jbc.M504988200 · DOI
  42. Hayashi, 2007, Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1, J Neurosci, 27, 1933, 10.1523/JNEUROSCI.5471-06.2007 · DOI · Paper page
  43. Mantuano, 2008, Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling, J Biol Chem, 283, 19904, 10.1074/jbc.M801762200 · DOI
  44. Martin, 2008, The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors, J Biol Chem, 283, 12004, 10.1074/jbc.M707607200 · DOI
  45. Mantuano, 2008, The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein, J Neurosci, 28, 11571, 10.1523/JNEUROSCI.3053-08.2008 · DOI
  46. Bacskai, 2000, The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors, Proc Natl Acad Sci U S A, 97, 11551, 10.1073/pnas.200238297 · DOI · Paper page
  47. Shi, 2009, Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway, Sci Signal, 2, ra18, 10.1126/scisignal.2000188 · DOI · Paper page
  48. May, 2002, Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain, J Biol Chem, 277, 18736, 10.1074/jbc.M201979200 · DOI · Paper page
  49. Zurhove, 2008, Gamma-secretase limits the inflammatory response through the processing of LRP1, Sci Signal, 1, ra15, 10.1126/scisignal.1164263 · DOI
  50. Gaultier, 2008, A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents, J Clin Invest, 118, 161, 10.1172/JCI32371 · DOI
  51. Gorovoy, 2010, Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages, J Leukoc Biol, 88, 769, 10.1189/jlb.0410220 · DOI
  52. Herz, 1992, LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation, Cell, 71, 411, 10.1016/0092-8674(92)90511-A · DOI · Paper page
  53. Hajjar, 1992, Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network, FASEB J, 6, 2933, 10.1096/fasebj.6.11.1644257 · DOI
  54. Croce, 2007, Intertwining of thrombosis and inflammation in atherosclerosis, Curr Opin Hematol, 14, 55, 10.1097/00062752-200701000-00011 · DOI
  55. Tuttolomondo, 2012, Atherosclerosis as an inflammatory disease, Curr Pharm Des, 18, 4266, 10.2174/138161212802481237 · DOI
  56. Stouffer, 1993, Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response, J Biol Chem, 268, 18340, 10.1016/S0021-9258(17)46850-5 · DOI
  57. Hu, 2006, Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice, Arterioscler Thromb Vasc Biol, 26, 2710, 10.1161/01.ATV.0000249641.96896.e6 · DOI
  58. Overton, 2007, Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse, Circ Res, 100, 670, 10.1161/01.RES.0000260204.40510.aa · DOI · Paper page
  59. Yancey, 2011, Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent, Circulation, 124, 454, 10.1161/CIRCULATIONAHA.111.032268 · DOI · Paper page
  60. Muratoglu, 2011, Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway, PLoS One, 6, e28846, 10.1371/journal.pone.0028846 · DOI
  61. Gaultier, 2008, Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor, Blood, 111, 5316, 10.1182/blood-2007-12-127613 · DOI
  62. Hussaini, 1990, Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages, J Biol Chem, 265, 19441, 10.1016/S0021-9258(17)45392-0 · DOI
  63. LaMarre, 1993, Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma, J Clin Invest, 91, 1219, 10.1172/JCI116283 · DOI
  64. Ceschin, 2009, Insulin induces the low density lipoprotein receptor-related protein 1 (LRP1) degradation by the proteasomal system in J774 macrophage-derived cells, J Cell Biochem, 106, 372, 10.1002/jcb.22014 · DOI
  65. Nilsson, 2012, Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids, Biochem Biophys Res Commun, 417, 1304, 10.1016/j.bbrc.2011.12.137 · DOI
  66. Costales, 2013, Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages, Atherosclerosis, 227, 79, 10.1016/j.atherosclerosis.2012.12.021 · DOI
  67. Willnow, 1994, Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist, Science, 264, 1471, 10.1126/science.7515194 · DOI
  68. Espirito Santo, 2004, Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol, Blood, 103, 3777, 10.1182/blood-2003-11-4051 · DOI
  69. Van Leuven, 1979, Demonstration of an alpha2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines, J Biol Chem, 254, 5155, 10.1016/S0021-9258(18)50573-1 · DOI
  70. Gonias, 1994, Alpha 2-macroglobulin and the alpha 2-macroglobulin receptor/LRP: a growth regulatory axis, Ann N Y Acad Sci, 737, 273, 10.1111/j.1749-6632.1994.tb44318.x · DOI
  71. Li, 1997, Expression of alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein on surfaces of tumour cells: a study using flow cytometry, Cancer Lett, 111, 199, 10.1016/S0304-3835(96)04520-X · DOI
  72. Montel, 2007, The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development, Cancer Res, 67, 9817, 10.1158/0008-5472.CAN-07-0683 · DOI
  73. McGarvey, 1996, In situ hybridization studies of alpha 2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma, Prostate, 28, 311, 10.1002/(SICI)1097-0045(199605)28:5<311::AID-PROS7>3.0.CO;2-E · DOI
  74. Huang, 2012, Low level of low-density lipoprotein receptor-related protein 1 predicts an unfavorable prognosis of hepatocellular carcinoma after curative resection, PLoS One, 7, e32775, 10.1371/journal.pone.0032775 · DOI
  75. Webb, 2000, Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion, J Cell Sci, 113, 123, 10.1242/jcs.113.1.123 · DOI
  76. Amos, 2007, Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion, Cancer Res, 67, 10241, 10.1158/0008-5472.CAN-07-0030 · DOI
  77. Fayard, 2009, The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression, Cancer Res, 69, 5690, 10.1158/0008-5472.CAN-08-4573 · DOI
  78. Gopal, 2011, A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion, PLoS One, 6, e17649, 10.1371/journal.pone.0017649 · DOI
  79. Chen, 2007, Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells, J Cell Sci, 120, 4009, 10.1242/jcs.013946 · DOI
  80. Song, 2009, Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9, Cancer Res, 69, 879, 10.1158/0008-5472.CAN-08-3379 · DOI · Paper page
  81. Pencheva, 2012, Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis, Cell, 151, 1068, 10.1016/j.cell.2012.10.028 · DOI · Paper page
  82. Qian, 2010, Macrophage diversity enhances tumor progression and metastasis, Cell, 141, 39, 10.1016/j.cell.2010.03.014 · DOI
  83. Staudt, 2013, Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors, Cancer Res, 73, 3902, 10.1158/0008-5472.CAN-12-4233 · DOI
  84. Wolf, 1992, Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain, Am J Pathol, 141, 37
  85. Campana, 2006, The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury, J Neurosci, 26, 11197, 10.1523/JNEUROSCI.2709-06.2006 · DOI
  86. Lopes, 1994, Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells, FEBS Lett, 338, 301, 10.1016/0014-5793(94)80288-2 · DOI · Paper page
  87. Barnett, 2004, Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion, Ann Neurol, 55, 458, 10.1002/ana.20016 · DOI
  88. Hendrickx, 2013, Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis, J Neuropathol Exp Neurol, 72, 106, 10.1097/NEN.0b013e31827fd9e8 · DOI · Paper page
  89. Benfey, 1982, Extensive elongation of axons from rat brain into peripheral nerve grafts, Nature, 296, 150, 10.1038/296150a0 · DOI
  90. Chen, 2007, Peripheral regeneration, Annu Rev Neurosci, 30, 209, 10.1146/annurev.neuro.30.051606.094337 · DOI
  91. Mantuano, 2011, The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury, J Neurosci, 31, 13376, 10.1523/JNEUROSCI.2850-11.2011 · DOI
  92. Orita, 2013, Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain, J Neurosci, 33, 5590, 10.1523/JNEUROSCI.3342-12.2013 · DOI · Paper page
  93. Mantuano, 2010, Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration, J Biol Chem, 285, 14259, 10.1074/jbc.M109.085126 · DOI
  94. Shi, 2011, Regulation of cytokine expression by Schwann cells in response to alpha2-macroglobulin binding to LRP1, J Neurosci Res, 89, 544, 10.1002/jnr.22576 · DOI
  95. Shubayev, 2006, TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve, Mol Cell Neurosci, 31, 407, 10.1016/j.mcn.2005.10.011 · DOI
  96. Akassoglou, 2000, Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury, J Cell Biol, 149, 1157, 10.1083/jcb.149.5.1157 · DOI
  97. Toth, 2009, The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population, Pain Med, 10, 918, 10.1111/j.1526-4637.2009.00655.x · DOI

Cited by

Sorted by citations

Metadata

Authors
Gonias, S. L., & Campana, W. M.
Venue
The American Journal of Pathology
Publisher
Elsevier BV
Published
2014-01
Volume
184
Issue
1
Pages
18-27
ISSN
0002-9440
DOI
10.1016/j.ajpath.2013.08.029
Cited by
175
References
3
Language
en
Licence
Funders
National Institutes of Health (R01 NS057456, R01 NS054671, R01 HL060551)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review