Cited by 323Circadian rhythm and melatoninSleep and Work-Related FatigueDietary Effects on Health

Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work

Salgado-Delgado, Roberto, Angeles-Castellanos, Manuel, Saderi, Nadia, Buijs, Ruud M., Escobar, Carolina·2010·Endocrinology

Abstract

Shift work or night work is associated with hypertension, metabolic syndrome, cancer, and other diseases. The cause for these pathologies is proposed to be the dissociation between the temporal signals from the biological clock and the sleep/activity schedule of the night worker. We investigated the mechanisms promoting metabolic desynchrony in a model for night work in rats, based on daily 8-h activity schedules during the resting phase. We demonstrate that the major alterations leading to internal desynchrony induced by this working protocol, flattened glucose and locomotor rhythms and the development of abdominal obesity, were caused by food intake during the rest phase. Shifting food intake to the normal activity phase prevented body weight increase and reverted metabolic and rhythmic disturbances of the shift work animals to control ranges. These observations demonstrate that feeding habits may prevent or induce internal desynchrony and obesity.

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Crossref · 10.1210/en.2009-0864

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  • Restricting food intake in rodents to the biological night during simulated night work prevents the gain in body mass and the accumulation of abdominal fat deposits induced by such a work schedule; perhaps by preventing internal desynchrony.

    “Recent work has demonstrated that restricting food intake in rodents to the biological night (typical active period) undertaking simulated night work prevents the gain in body mass and the accumulation of abdominal fat deposits induced by such a work schedule; perhaps by preventing internal desynchrony (Salgado-Delgado et al., 2010).”

    From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Salgado-Delgado et al., 2010

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Authors
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C.
Affiliations
  • Departamento de Anatomía (R.S.-D., M.A.-C., C.E.), Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México DF 04510, México
  • Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (MX)
Corresponding author
Escobar, Carolina
Venue
Endocrinology
Published
2010-01-15
Volume
151
Issue
3
Pages
1019-1029
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W1965275927
Cited by
323
References
62
Citations by year
2026: 6 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 25 · 2021: 21 · 2020: 21 · 2019: 14 · 2018: 19 · 2017: 28 · 2016: 22 · 2015: 18 · 2014: 30 · 2013: 32 · 2012: 22
FWCI
11.32
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
shift work, night work, circadian desynchrony, meal timing, obesity, locomotor rhythm, metabolic syndrome, biological clock, body weight
MeSH terms
Animals, Behavior, Animal, Body Temperature, Body Weight, Circadian Rhythm, Corticosterone, Disease Models, Animal, Eating, Male, Obesity, Suprachiasmatic Nucleus, Work Schedule Tolerance, Rats, Wistar, Intra-Abdominal Fat, Rats

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