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Molecular control of vertebrate iron homeostasis by iron regulatory proteins

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Wallander, Michelle L., Leibold, Elizabeth A., Eisenstein, Richard S.·2006·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI 10.1016/j.bbamcr.2006.05.004PMC PMC2291536

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Abstract

Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins post-transcriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system.

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See all 287

Authors: Wallander, M. L., Leibold, E. A., & Eisenstein, R. S.
Affiliations: University of Utah (US)
University of Wisconsin–Madison (US)
Corresponding author: Eisenstein, Richard S.
ORCID: Wallander, Michelle L.
Leibold, Elizabeth A.
Eisenstein, Richard S.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher: Elsevier BV
Published: 2006-07
Volume: 1763
Issue: 7
Pages: 668-689
ISSN: 0167-4889 (ISSN-L)
DOI: 10.1016/j.bbamcr.2006.05.004
PMC: PMC2291536
OpenAlex: W2121798267
Cited by: 287
References: 307
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 19 · 2013: 18 · 2012: 22
FWCI: 2.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2574 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (GM 45201, R01GM045201)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 66600, R56DK066600, DK47219, R01DK066600)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: iron homeostasis, iron regulatory proteins, iron regulatory protein 1, IRP2, RNA-binding proteins, post-transcriptional regulation, mRNA stability, translational regulation, iron metabolism disorders, iron deficiency, iron overload
MeSH terms: Animals, Homeostasis, Iron, Vertebrates, Iron-Regulatory Proteins

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Molecular control of vertebrate iron homeostasis by iron regulatory proteins

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