A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Membrane vesicles as conveyors of immune responses

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

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Strategies in the design of nanoparticles for therapeutic applications

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Extracellular vesicles: biology and emerging therapeutic opportunities

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B lymphocytes secrete antigen-presenting vesicles.

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Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

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Rab27a and Rab27b control different steps of the exosome secretion pathway

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Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

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Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

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Gene transfer into mouse lyoma cells by electroporation in high electric fields.

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Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

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The nucleic acids

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Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

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Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

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Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

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Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

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The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

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Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

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Exosomal-like vesicles are present in human blood plasma

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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

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Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

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NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy

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Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

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A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

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ExoCarta 2012: database of exosomal proteins, RNA and lipids

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Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Modern methods for delivery of drugs across the blood–brain barrier

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Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

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Tissue-factor–bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation

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Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

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Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

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Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

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Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

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Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

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Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

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Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

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Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

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Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

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First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

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siRNA vs. shRNA: Similarities and differences

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Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

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Interaction and uptake of exosomes by ovarian cancer cells

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Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

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Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

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Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

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Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

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Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

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Exosome-mediated delivery of siRNA in vitro and in vivo

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Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

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Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

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Exosomes for targeted siRNA delivery across biological barriers

Andaloussi, S. E., Lakhal‐Littleton, S., Mäger, I., & Wood, M. J. A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.008 · Cited by 555

Exosomes as intercellular signalosomes and pharmacological effectors

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Exosome mimetics: a novel class of drug delivery systems

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Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520

Isolation and Characterization of RNA-Containing Exosomes

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Exosomes are natural carriers of exogenous siRNA to human cells in vitro

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Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Kim, J. W., Wieckowski, E. U., Taylor, D. D., Reichert, T. E., Watkins, S. C., & Whiteside, T. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1010.11.3 · Cited by 496

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

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Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

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Liposomal siRNA nanocarriers for cancer therapy

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Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Chen, T. S., Arslan, F., Yin, Y., Tan, S. S., Lai, R. C., Choo, A. B. H., Padmanabhan, J., Lee, C. N., de Kleijn, D. P. V., & Lim, S. K. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-47 · Cited by 407

Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes

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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

Ramteke, A. S., Ting, H., Agarwal, C., Mateen, S., Somasagara, R. R., Hussain, A., Graner, M. W., Frederick, B. A., Agarwal, R., & Deep, G. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22124 · Cited by 391

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

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Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

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Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

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Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

Lai, C. P., & Breakefield, X. O. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00228 · Cited by 325

The EGF receptor is required for efficient liver regeneration

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Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin

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Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth

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Maximizing exosome colloidal stability following electroporation

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Exosome formation during maturation of mammalian and avian reticulocytes: Evidence that exosome release is a major route for externalization of obsolete membrane proteins

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Microvesicle-associated AAV Vector as a Novel Gene Delivery System

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The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions

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Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

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