Cited by 704Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

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A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, Kasper Bendix, Gudbergsson, Johann Mar, Skov, Martin Najbjerg, Pilgaard, Linda, Moos, Torben, Duroux, Meg·2014·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

DOI 10.1016/j.bbcan.2014.04.005

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Abstract

Exosomes denote a class of secreted nanoparticles defined by size, surface protein and lipid composition, and the ability to carry RNA and proteins. They are important mediators of intercellular communication and regulators of the cellular niche, and their altered characteristics in many diseases, such as cancer, suggest them to be important both for diagnostic and therapeutic purposes, prompting the idea of using exosomes as drug delivery vehicles, especially for gene therapy. This review covers the current status of evidence presented in the field of exosome-based drug delivery systems. Components for successful exosome-based drug delivery, such as choice of donor cell, therapeutic cargo, use of targeting peptide, loading method and administration route are highlighted and discussed with a general focus pertaining to the results obtained in models of different cancer types. In addition, completed and on-going clinical trials are described, evaluating exosome-based therapies for the treatment of different cancer types. Due to their endogenous origin, exosome-based drug delivery systems may have advantages in the treatment of cancer, but their design needs further refinement to justify their usage on the clinical scale.

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Authors: Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M.
Affiliations: Aalborg University (DK)
Corresponding author: Duroux, Meg
ORCID: Johnsen, Kasper Bendix
Gudbergsson, Johann Mar
Pilgaard, Linda
Moos, Torben
Duroux, Meg
Venue: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher: Elsevier BV
Published: 2014-08
Volume: 1846
Issue: 1
Pages: 75-87
ISSN: 0304-419X (ISSN-L)
DOI: 10.1016/j.bbcan.2014.04.005
OpenAlex: W2151079805
Cited by: 704
References: 125
Citations by year: 2026: 16 · 2025: 45 · 2024: 51 · 2023: 60 · 2022: 63 · 2021: 69 · 2020: 77 · 2019: 78 · 2018: 82 · 2017: 76 · 2016: 46 · 2015: 34 · 2014: 6
FWCI: 5.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders: Harboefonden (839070)
Spar Nord Fonden (839071)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: exosomes, exosome-based drug delivery, targeted cancer therapy, gene therapy, intercellular communication, targeting peptides, route of administration, clinical trials, cancer
MeSH terms: Animals, Antineoplastic Agents, Drug Carriers, Humans, Neoplasms, Pharmaceutical Vehicles, Nanoparticles, Exosomes, Molecular Targeted Therapy

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A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

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