The DOI matches its Crossref record; 25 of the 27 references it cites were found in a registry or an index.
Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood
Open accessAbstract
Although research has established links between feelings of social isolation and inflammation, the direction of these effects is unclear. Based on the role that proinflammatory cytokines play in initiating "sickness behavior," which includes symptoms such as social withdrawal, it is possible that inflammatory processes heighten feelings of 'social disconnection.' Here, we examined whether exposure to an inflammatory challenge increased self-reported feelings of social disconnection. In addition, because both inflammatory processes and feelings of social disconnection contribute to depressive symptoms, we also explored whether increases in feelings of social disconnection played a role in the link between inflammation and depressed mood. Participants were randomly assigned to either receive endotoxin, an inflammatory challenge, or placebo. Proinflammatory cytokines (IL-6, TNF-alpha) were collected at baseline and then hourly for 6h. Participants completed self-reports of sickness symptoms ("fatigue"), social disconnection ("I feel disconnected from others"), and depressed mood ("unhappy") hourly. Results revealed that endotoxin led to significant increases (from baseline) in IL-6 and TNF-alpha levels as well as feelings of social disconnection and depressed mood. Moreover, controlling for increases in social disconnection eliminated the relationship between exposure to inflammatory challenge and depressed mood. This study demonstrates that inflammation can have social psychological consequences, which may play a role in cytokine-related depressive symptoms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Specifically, endotoxin administration in healthy controls increases IL-6 and TNF-α levels (Eisenberger et al, 2010) and amygdala response to socially threatening stimuli (Harrison et al, 2009b;Inagaki et al, 2012).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Eisenberger et al, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101
Biological basis of the behavior of sick animals
Hart, B. L. (1988) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(88)80004-6 · Cited by 2,223
The clinical significance of loneliness: a literature review
Heinrich, L. M., & Gullone, E. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.04.002 · Cited by 1,986 · cited 5×
“…it would be interesting to examine whether inflammatory activity also decreases the sense that one is socially supported, as a perceived lack of social support is a risk factor for both endogenous and cytokineassociated forms of depression (Capuron et al., 2004; Heinrich and Gullone, 2006).”
InfluentialGender differences in depression
Nolen-Hoeksema, S. (2001) · Current Directions in Psychological Science · doi:10.1111/1467-8721.00142 · Cited by 1,474
Structured Clinical Interview for DSM-III-R Personality Disorders
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2012) · PsycTESTS Dataset · doi:10.1037/t07827-000 · Cited by 1,403
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Social Ties and Susceptibility to the Common Cold
Heeler, R. M. (1997) · JAMA · doi:10.1001/jama.1997.03550150035019 · Cited by 1,300
Social ties and health: The benefits of social integration
Seeman, T. E. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00095-6 · Cited by 1,137
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
Cacioppo, J. T., & Hawkley, L. C. (2003) · Perspectives in Biology and Medicine · doi:10.1353/pbm.2003.0049 · Cited by 887
Cited by
Sorted by citations
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
Self-citationRaison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617
Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective
Irwin, M. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115205 · Cited by 1,325
“Third, experimental activation of inflammation induces increases of depressive symptoms along with activation of brain sites that regulate positive and negative affect (Eisenberger et al. 2009, 2010a,b).”
BackgroundSelf-citationEisenberger, N. I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3231 · Cited by 1,016
Self-citationInflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786
The kynurenine pathway: a finger in every pie
Savitz, J. B. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0414-4 · Cited by 805
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
Self-citationInflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596
Self-citationIs depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524
The neural bases of social pain: Evidence for shared representations with physical pain
Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182464dd1 · Cited by 492
Self-citationBower, J. E., Ganz, P. A., Irwin, M. R., Kwan, L. C., Breen, E. C., & Cole, S. W. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.1154 · Cited by 514
Self-citationThe neurobiology of interoception in health and disease
Quadt, L., Critchley, H., & Garfinkel, S. N. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13915 · Cited by 488
Lim, M. H., Eres, R., & Vasan, S. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01889-7 · Cited by 438
Kynurenines in CNS disease: regulation by inflammatory cytokines.
Campbell, B. M., Charych, E., Lee, A. W., & Möller, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00012 · Cited by 409
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415
Diamond, L. M., & Alley, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104720 · Cited by 412
In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior
Eisenberger, N. I., Moieni, M., Inagaki, T. K., Muscatell, K. A., & Irwin, M. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.141 · Cited by 423
Self-citationSocial Pain and the Brain: Controversies, Questions, and Where to Go from Here
Eisenberger, N. I. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115146 · Cited by 417
Self-citationCan interoception improve the pragmatic search for biomarkers in psychiatry?
Khalsa, S. S., & Lapidus, R. C. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00121 · Cited by 366
Hikikomori : Multidimensional understanding, assessment, and future international perspectives
Kato, T. A., Kanba, S., & Teo, A. R. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12895 · Cited by 335
Smith, K. J., Gavey, S., Riddell, N. E., Kontari, P., & Victor, C. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.002 · Cited by 364
Zunszain, P. A., Hepgul, N., & Pariante, C. M. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_211 · Cited by 327
Cole, S. W., Capitanio, J. P., Chun, K., Arevalo, J. M. G., Ma, J., & Cacioppo, J. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514249112 · Cited by 310
A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin
Baganz, N. L., & Blakely, R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300186b · Cited by 316
Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014218108 · Cited by 306
Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302
Murray, D. R., & Schaller, M. (2016) · Advances in Experimental Social Psychology · doi:10.1016/bs.aesp.2015.09.002 · Cited by 282
Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
Hackett, R. A., Hamer, M., Endrighi, R., Brydon, L., & Steptoe, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.016 · Cited by 272
Moieni, M., Irwin, M. R., Jevtic, I., Olmstead, R., Breen, E. C., & Eisenberger, N. I. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.17 · Cited by 273
Self-citationLavretsky, H., Alstein, L. L., Olmstead, R. E., Ercoli, L. M., Riparetti-Brown, M., St. Cyr, N., & Irwin, M. R. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820ee9ef · Cited by 268
Self-citationCumulative Depression Episodes Predict Later C-Reactive Protein Levels: A Prospective Analysis
Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.023 · Cited by 265
Inflammation selectively enhances amygdala activity to socially threatening images
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., Cole, S. W., & Eisenberger, N. I. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.090 · Cited by 264
Self-citationThe evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253
Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics
Antoni, M. H., Lutgendorf, S. K., Blomberg, B., Carver, C. S., Lechner, S., Diaz, A., Stagl, J., Arevalo, J. M. G., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.007 · Cited by 251
Loneliness, eudaimonia, and the human conserved transcriptional response to adversity
Cole, S. W., Levine, M. E., Arevalo, J. M. G., Ma, J., Weir, D. R., & Crimmins, E. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.001 · Cited by 238
Affective disturbance in rheumatoid arthritis: Psychological and disease-related pathways
Sturgeon, J. A., Finan, P. H., & Zautra, A. J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.112 · Cited by 232
Frolkis, A. D., Vallerand, I. A., Shaheen, A.-A., Lowerison, M. W., Swain, M. G., Barnabe, C., Patten, S. B., & Kaplan, G. G. (2019) · Gut · doi:10.1136/gutjnl-2018-317182 · Cited by 228
Integrated Neurobiology of Bipolar Disorder
Maletic, V., & Raison, C. L. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00098 · Cited by 236
Irwin, M. R., Olmstead, R., Breen, E. C., Witarama, T., Carrillo, C., Sadeghi, N., Arevalo, J. M. G., Ma, J., Nicassio, P., Bootzin, R., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.010 · Cited by 227
Self-citationInflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology
Goldsmith, D. R., Bekhbat, M., Mehta, N. D., & Felger, J. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.003 · Cited by 229
Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression
D’Mello, C., & Swain, M. G. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_37 · Cited by 226
Hannestad, J., DellaGioia, N., Gallezot, J.-D., Lim, K., Nabulsi, N., Esterlis, I., Pittman, B., Lee, J.-Y., O’Connor, K. C., Pelletier, D., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.06.010 · Cited by 204
Schedlowski, M., Engler, H., & Grigoleit, J.-S. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.09.015 · Cited by 195
Infectious diseases and social distancing in nature
Stockmaier, S., Stroeymeyt, N., Shattuck, E. C., Hawley, D. M., Ancel, L. W., & Bolnick, D. I. (2021) · Science · doi:10.1126/science.abc8881 · Cited by 191
Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 186
The MRL/lpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus
Gulinello, M. E., & Putterman, C. (2011) · BioMed Research International · doi:10.1155/2011/207504 · Cited by 178
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176
Self-citationSleep disturbance, inflammation and depression risk in cancer survivors
Irwin, M. R., Olmstead, R. E., Ganz, P. A., & Haque, R. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.002 · Cited by 173
Self-citationRaison, C. L., Lowry, C. A., & Rook, G. A. W. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.161 · Cited by 169
Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165799 · Cited by 171
Brondolo, E., Hausmann, L., Jhalani, J., Pencille, M., Atencio-Bacayon, J., Kumar, A., Kwok, J., Ullah, J., Roth, A., Chen, D., et al. (2011) · Annals of Behavioral Medicine · doi:10.1007/s12160-011-9265-1 · Cited by 166
Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165
Lasselin, J., Schedlowski, M., Karshikoff, B., Engler, H., Lekander, M., & Konsman, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.001 · Cited by 165
The consequences of pain: The social and physical pain overlap on psychological responses
Riva, P., Wirth, J. H., & Williams, K. D. (2011) · European Journal of Social Psychology · doi:10.1002/ejsp.837 · Cited by 174
Haroon, E., & Miller, A. H. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_40 · Cited by 153
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152
Wager‐Smith, K., & Markou, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.010 · Cited by 153
Chronic Pain and Suicide: Understanding the Association
Hooley, J. M., Franklin, J. C., & Nock, M. K. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0435-2 · Cited by 150
Muscatell, K. A., Moieni, M., Inagaki, T. K., Dutcher, J. M., Jevtic, I., Breen, E. C., Irwin, M. R., & Eisenberger, N. I. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.022 · Cited by 146
Self-citationHuman sickness behavior: Ultimate and proximate explanations
Shattuck, E. C., & Muehlenbein, M. P. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22698 · Cited by 154
A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis
Schrepf, A., Kaplan, C. M., Ichesco, E., Larkin, T. E., Harte, S. E., Harris, R. E., Murray, A. D., Waiter, G. D., Clauw, D. J., & Basu, N. (2018) · Nature Communications · doi:10.1038/s41467-018-04648-0 · Cited by 144
Jaremka, L. M., Lindgren, M. E., & Kiecolt‐Glaser, J. K. (2013) · Depression and Anxiety · doi:10.1002/da.22078 · Cited by 148
Brain-body interactions underlying the association of loneliness with mental and physical health
Quadt, L., Esposito, G., Critchley, H., & Garfinkel, S. N. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.015 · Cited by 154
D’Mello, C., & Swain, M. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00184.2011 · Cited by 136
The role of the ventral striatum in inflammatory-induced approach toward support figures
Inagaki, T. K., Muscatell, K. A., Irwin, M. R., Moieni, M., Dutcher, J. M., Jevtic, I., Breen, E. C., & Eisenberger, N. I. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.10.006 · Cited by 132
Self-citationAmiri, S., Haj‐Mirzaian, A., Rahimi-Balaei, M., Razmi, A., Kordjazy, N., Shirzadian, A., Mehr, S. E., Sianati, H., & Dehpour, A. R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.032 · Cited by 133
Gur, T. L., Palkar, A. V., Rajasekera, T., Allen, J., Niraula, A., Godbout, J., & Bailey, M. T. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.025 · Cited by 127
Engler, H., Brendt, P., Wischermann, J., Wegner, A., Rohling, R., Schoemberg, T., Meyer, U., Gold, R., Peters, J., Benson, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.264 · Cited by 127
Bower, J. E., & Kuhlman, K. R. (2023) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-080621-045153 · Cited by 133
Toll-Like Receptor Signaling in Depression
Figueroa‐Hall, L. K., Paulus, M. P., & Savitz, J. B. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104843 · Cited by 122
Uthaug, M. V., Lancelotta, R., Szabo, A., Davis, A. K., Riba, J., & Ramaekers, J. G. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05414-w · Cited by 117
Depression subtyping based on evolutionary psychiatry: Proximate mechanisms and ultimate functions
Rantala, M. J., Luoto, S., Krams, I. A., & Karlsson, H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.012 · Cited by 125
A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase
Davies, Christmas, D. M., & Potokar, J. P. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s17573 · Cited by 121
Naturalistic Observation of Health-Relevant Social Processes
Mehl, M. R., Robbins, M. L., & Deters, F. G. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182545470 · Cited by 126
Leschak, C. J., & Eisenberger, N. I. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000685 · Cited by 129
Self-citationLasselin, J., Lekander, M., Benson, S., Schedlowski, M., & Engler, H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00869-2 · Cited by 121
Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans
Hannestad, J., Subramanyam, K., DellaGioia, N., Planeta-Wilson, B., Weinzimmer, D., Pittman, B., & Carson, R. E. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.097014 · Cited by 113
Inflammation, Self-Regulation, and Health: An Immunologic Model of Self-Regulatory Failure
Shields, G. S., Moons, W. G., & Slavich, G. M. (2017) · Perspectives on Psychological Science · doi:10.1177/1745691616689091 · Cited by 121
Hennessy, M. B., Terrence Deak, B., & Schiml, P. A. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.021 · Cited by 110
Lasselin, J., Lekander, M., Axelsson, J., & Karshikoff, B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.005 · Cited by 106
Kruse, J. L., Congdon, E. L., Olmstead, R., Njau, S. N., Breen, E. C., Narr, K. L., Espinoza, R. T., & Irwin, M. R. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17m11597 · Cited by 111
Self-citationMitigating Cellular Inflammation in Older Adults: A Randomized Controlled Trial of Tai Chi Chih
Irwin, M. R., & Olmstead, R. E. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3182330fd3 · Cited by 107
Self-citationWalker, E., Ploubidis, G., & Fancourt, D. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.08.189 · Cited by 104
Social context modulates sickness behavior
Lopes, P. C., Adelman, J. S., Wingfield, J. C., & Bentley, G. E. (2012) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-012-1397-1 · Cited by 102
Schaller, M. (2015) · Wiley eBooks · doi:10.1002/9781119125563.evpsych107 · Cited by 103
Cui, W., Ning, Y., Hong, W., Wang, J., Liu, Z., & Li, M. D. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1306-3 · Cited by 102
Inflammation and depression in young people: a systematic review and proposed inflammatory pathways
Toenders, Y. J., Laskaris, L., Davey, C. G., Berk, M., Milaneschi, Y., Lamers, F., Penninx, B. W. J. H., & Schmaal, L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01306-8 · Cited by 106
Citalopram reduces endotoxin-induced fatigue
Hannestad, J., DellaGioia, N., Ortiz, N., Pittman, B., & Bhagwagar, Z. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.013 · Cited by 95
Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin
Moieni, M., Irwin, M. R., Jevtic, I., Breen, E. C., & Eisenberger, N. I. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.002 · Cited by 95
Self-citationRobson, M. J., Quinlan, M. A., & Blakely, R. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00412 · Cited by 96
Lopresti, A. L. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417701996 · Cited by 102
Kullmann, J. S., Grigoleit, J.-S., Lichte, P., Kobbe, P., Rosenberger, C., Banner, C., Wolf, O. T., Engler, H., Oberbeck, R., Elsenbruch, S., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22063 · Cited by 93
Hanken, K., Eling, P., & Hildebrandt, H. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00264 · Cited by 92
Sun, Y., Bai, L., Niu, X., Wang, Z., Yin, B., Bai, G., Zhang, D., Gan, S., Sun, C., Wang, S., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01120 · Cited by 97
Benson, S., Kattoor, J., Wegner, A., Hammes, F., Reidick, D., Grigoleit, J.-S., Engler, H., Oberbeck, R., Schedlowski, M., & Elsenbruch, S. (2012) · Pain · doi:10.1016/j.pain.2011.12.001 · Cited by 89
Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment
Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88
Mason, N. L., Szabó, A., Kuypers, K. P. C., Mallaroni, P., de la Torre, R., Reckweg, J. T., Tse, D. H. Y., Hutten, N. R. P. W., Feilding, A., & Ramaekers, J. G. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.004 · Cited by 94
A global measure of sickness behaviour: Development of the Sickness Questionnaire
Andréasson, A., Wicksell, R. K., Lodin, K., Karshikoff, B., Axelsson, J., & Lekander, M. (2016) · Journal of Health Psychology · doi:10.1177/1359105316659917 · Cited by 83
Early adversity and health outcomes in young adulthood: The role of ongoing stress.
Raposa, E. B., Hammen, C. L., Brennan, P. A., O’Callaghan, F., & Najman, J. M. (2013) · Health Psychology · doi:10.1037/a0032752 · Cited by 84
Effects of inflammation on social processes and implications for health
Moieni, M., & Eisenberger, N. I. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13864 · Cited by 89
Self-citation
Metadata
- Authors
- Eisenberger, N. I., Inagaki, T. K., Mashal, N. M., & Irwin, M. R.
- Affiliations
- University of California, Los Angeles (US)
- Northwestern University (US)
- Corresponding author
- Eisenberger, Naomi I.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 24
- Issue
- 4
- Pages
- 558-563
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2856755
- OpenAlex
- W2161296293
- Cited by
- 413
- References
- 27
- Citations by year
- 2026: 32 · 2025: 25 · 2024: 24 · 2023: 25 · 2022: 33 · 2021: 38 · 2020: 26 · 2019: 21 · 2018: 28 · 2017: 20 · 2016: 27 · 2015: 24 · 2014: 25 · 2013: 14 · 2012: 26
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Dana Foundation
- National Institute on Aging (AG 026364, R01AG026364, R01AG034588, P30AG028748)
- National Heart, Lung, and Blood Institute (HL 079955, R01HL079955)
- National Institute of Mental Health (T32MH019925, T32 MH 19925)
- National Cancer Institute (R01CA116778, CA-10014152, CA-116778)
- National Center for Research Resources ((M01 RR00865), M01RR000865)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- inflammation, social disconnection, social isolation, endotoxin, sickness behavior, inflammatory cytokines, interleukin-6, TNF-α, depressive mood, depressive symptoms, fatigue, social withdrawal
- MeSH terms
- Adolescent, Adult, Depression, Double-Blind Method, Endotoxins, Fatigue, Female, Humans, Inflammation, Interpersonal Relations, Male, Social Behavior, Tumor Necrosis Factor-alpha, Interleukin-6, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
