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Early life adversity drives sex‐specific anhedonia and meningeal immune gene expression through mast cell activation

Duque-Wilckens, Natalia, Teis, Robert, Sarno, Erika, Stoelting, Frauke, Khalid, Sonia, Dairi, Zakaria, Douma, Alex, Maradiaga, Nidia, Hench, Stina, Dharshika, Christine D., Thelen, Kyan M., Gulbransen, Brian, Robison, A.J., Moeser, Adam J.·2022·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2022.03.009PMC PMC9149134
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Fig. 1. NMSEW plus adult stress reduces sucrose preference in females but not males, and administration of Ketotifen exerts sex and treatment specific effects. A. Experimental timeline. B. Three-way ANOVA assessing effects of sex, early life treatment, adult treatment and their interaction on sucrose preference behavior followed by Fisher LSD. *p < 0.05.
Fig. 1. NMSEW plus adult stress reduces sucrose preference in females but not males, and administration of Ketotifen exerts sex and treatment specific effects. A. Experimental timeline. B. Three-way ANOVA assessing effects of sex, early life treatment, adult treatment and their interaction on sucrose preference behavior followed by Fisher LSD. *p < 0.05.CC BY-NC-ND · PubMed Central
Fig. 2. NMSEW exerts sex-specific effects on dura mater gene expressionThree-way ANOVA assessing effects of sex, early life treatment, adult treatment and their interaction on the dura mater gene expression of A. mast cell-specific protease cma1, B. the rate limiting enzyme for histamine synthesis hdc, C. the inflammatory cytokines il-6 and D. tnf alpha, E. the tryptophan catalizing enzyme tph1, and F. the mouse endothelial growth factor vegf-c followed by Fisher LSD. *p < 0.05, **p < 0.01 ***p=<0.001, ****p < 0.0001.
Fig. 2. NMSEW exerts sex-specific effects on dura mater gene expressionThree-way ANOVA assessing effects of sex, early life treatment, adult treatment and their interaction on the dura mater gene expression of A. mast cell-specific protease cma1, B. the rate limiting enzyme for histamine synthesis hdc, C. the inflammatory cytokines il-6 and D. tnf alpha, E. the tryptophan catalizing enzyme tph1, and F. the mouse endothelial growth factor vegf-c followed by Fisher LSD. *p < 0.05, **p < 0.01 ***p=<0.001, ****p < 0.0001.CC BY-NC-ND · PubMed Central
Fig. 3. Administration of Ketotifen does not affect dura mater gene expression in NH animals. A. Experimental timeline. B-G. No effects of Ketotifen are seen on expression of cma1, hdc,il-6,tnf alpha, tph1, or vegf-c in NH males or females.
Fig. 3. Administration of Ketotifen does not affect dura mater gene expression in NH animals. A. Experimental timeline. B-G. No effects of Ketotifen are seen on expression of cma1, hdc,il-6,tnf alpha, tph1, or vegf-c in NH males or females.CC BY-NC-ND · PubMed Central
Fig. 4. Mast cells are not homogeneous across dura mater regions. A: diagram showing regions of dura mater analyzed:: parietal, interparietal, Sagittal sinus and Transverse sinus. B: Total mast cell (MC) number per mm2 significantly differs by dura mater region, with interparietal region showing the highest mast cell density. C: Activation level of mast cells differs by dura mater region, with transverse region showing the highest activation. D: Relative expression of pseudopodia varies by dura mater region, with interparietal region showing the highest expression. One way ANOVA followed by Dunnett’s multiple comparisons test, **p < 0.01, ****p < 0.0001. n = 49–52 per group.
Fig. 4. Mast cells are not homogeneous across dura mater regions. A: diagram showing regions of dura mater analyzed:: parietal, interparietal, Sagittal sinus and Transverse sinus. B: Total mast cell (MC) number per mm2 significantly differs by dura mater region, with interparietal region showing the highest mast cell density. C: Activation level of mast cells differs by dura mater region, with transverse region showing the highest activation. D: Relative expression of pseudopodia varies by dura mater region, with interparietal region showing the highest expression. One way ANOVA followed by Dunnett’s multiple comparisons test, **p < 0.01, ****p < 0.0001. n = 49–52 per group.CC BY-NC-ND · PubMed Central
Fig. 5. NMSEW plus adult stress induces histological changes in dura mater mast cells. A. Experimental timeline. B. Photomicrograph showing subregions of dura mater and examples of mast cell features quantified: active mast cell (orange arrows), inactive mast cell (black arrows), and presence of pseudopodia (red arrows). C, G, K, O. Photomicrograph showing examples of mast cells in interparietal, parietal, sagittal sinus, and transverse sinus regions, respectively. D, F. Compared to NH plus adult stress (NH + St), NMSEW plus adult stress (NMSEW + St) increases total mast cell number (two way ANOVA main effect of early life treatment, *p = 0.03) and reduces relative pseudopodia expression (two way ANOVA main effect of early life treatment, *p = 0.01) in the interparietal dura mater.I. In the parietal region, NH males showed increased activation levels compared to NH females (Šídak’s multiple comparisons test *p = 0.003), and NMSEW reduced the activation level in males only (Šídák’s multiple comparisons test *p = 0.01) N. NMSEW increases relative pseudopodia expression in the sagittal sinus region (two way ANOVA main effect of early life treatment, *p = 0.01). Q. Females show increased activation levels of mast cells located in the transverse sinus region (two way ANOVA main effect of sex, *p = 0.02).
Fig. 5. NMSEW plus adult stress induces histological changes in dura mater mast cells. A. Experimental timeline. B. Photomicrograph showing subregions of dura mater and examples of mast cell features quantified: active mast cell (orange arrows), inactive mast cell (black arrows), and presence of pseudopodia (red arrows). C, G, K, O. Photomicrograph showing examples of mast cells in interparietal, parietal, sagittal sinus, and transverse sinus regions, respectively. D, F. Compared to NH plus adult stress (NH + St), NMSEW plus adult stress (NMSEW + St) increases total mast cell number (two way ANOVA main effect of early life treatment, *p = 0.03) and reduces relative pseudopodia expression (two way ANOVA main effect of early life treatment, *p = 0.01) in the interparietal dura mater.I. In the parietal region, NH males showed increased activation levels compared to NH females (Šídak’s multiple comparisons test *p = 0.003), and NMSEW reduced the activation level in males only (Šídák’s multiple comparisons test *p = 0.01) N. NMSEW increases relative pseudopodia expression in the sagittal sinus region (two way ANOVA main effect of early life treatment, *p = 0.01). Q. Females show increased activation levels of mast cells located in the transverse sinus region (two way ANOVA main effect of sex, *p = 0.02).CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 110

  1. Allen, 1997, Attentional Activation of the Cerebellum Independent of Motor Involvement, Science, 275, 1940, 10.1126/science.275.5308.1940 · DOI
  2. Allie, 2013, Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection, Sci. Rep., 3, 1809, 10.1038/srep01809 · DOI
  3. Amini-Khoei, 2017, Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation, Prog. Neuropsychopharmacol. Biol. Psychiatry, 76, 169, 10.1016/j.pnpbp.2017.02.022 · DOI · Paper page
  4. Amini-Khoei, 2019, On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress, Int. Immunopharmacol., 66, 242, 10.1016/j.intimp.2018.11.037 · DOI
  5. Antila, 2017, Development and plasticity of meningeal lymphatic vessels, J. Exp. Med., 214, 3645, 10.1084/jem.20170391 · DOI
  6. Avitsur, 2006, Role of early stress in the individual differences in host response to viral infection, Brain. Behav. Immun., 20, 339, 10.1016/j.bbi.2005.09.006 · DOI
  7. Ayyadurai, 2017, Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology, J. Leukoc. Biol., 102, 1299, 10.1189/jlb.2HI0317-088RR · DOI · Paper page
  8. Baba, 2016, Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties, Cell. Physiol. Biochem., 38, 15, 10.1159/000438605 · DOI
  9. Baer, 1998, Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-κB p50, Mol. Cell. Biol., 18, 5678, 10.1128/MCB.18.10.5678 · DOI
  10. Balin, 1986, Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey, J. Comp. Neurol., 251, 260, 10.1002/cne.902510209 · DOI · Paper page
  11. Banqueri, 2017, Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats, Behav. Brain Res., 324, 77, 10.1016/j.bbr.2017.02.006 · DOI
  12. Barnes, 1990, Ketotifen and its analogues reduce aversive responding in the rodent, Pharmacol. Biochem. Behav., 37, 785, 10.1016/0091-3057(90)90564-X · DOI
  13. Bauer, 2009, Cerebellar volume and cognitive functioning in children who experienced early deprivation, Biol. Psychiatry, 66, 1100, 10.1016/j.biopsych.2009.06.014 · DOI · Paper page
  14. Baumeister, 2016, Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α, Mol. Psychiatry, 21, 642, 10.1038/mp.2015.67 · DOI · Paper page
  15. Bradford, 2012, Association between early adverse life events and irritable bowel syndrome, Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc., 10, e1
  16. Brancato, 2017, Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens, Neuroscience, 350, 180, 10.1016/j.neuroscience.2017.03.014 · DOI
  17. Brennenstuhl, 2015, The Painful Legacy of Childhood Violence: Migraine Headaches Among Adult Survivors of Adverse Childhood Experiences, Headache J. Head Face Pain, 55, 973, 10.1111/head.12614 · DOI
  18. Breslin, 2007, Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism, Am. J. Physiol.-Heart Circ. Physiol., 293, H709, 10.1152/ajpheart.00102.2007 · DOI
  19. Brooks, 2016, Early-life adversity and orbitofrontal and cerebellar volumes in adults with obsessive–compulsive disorder: Voxel-based morphometry study, Br. J. Psychiatry, 208, 34, 10.1192/bjp.bp.114.162610 · DOI
  20. Bulfone-Paus, 2015, Mast Cells as Regulators of T Cell Responses, Front. Immunol., 6, 10.3389/fimmu.2015.00394 · DOI
  21. Burks, 2019, Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of Nf1-Deficient Mice, Mol. Cancer Ther., 18, 2321, 10.1158/1535-7163.MCT-19-0123 · DOI
  22. Casimir, 2013, Sex and inflammation in respiratory diseases: a clinical viewpoint, Biol. Sex Differ., 4, 16, 10.1186/2042-6410-4-16 · DOI
  23. Castagliuolo, 1996, Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells, Am. J. Physiol.-Gastrointest. Liver Physiol., 271, G884, 10.1152/ajpgi.1996.271.5.G884 · DOI
  24. Coles, 2017, Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain, Prog. Neurobiol., 156, 107, 10.1016/j.pneurobio.2017.05.002 · DOI · Paper page
  25. D’Costa, 2018, Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability, J. Allergy Clin. Immunol.
  26. Dahdah, 2014, Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis, J. Clin. Invest., 124, 4577, 10.1172/JCI75212 · DOI
  27. Danese, 2007, Childhood maltreatment predicts adult inflammation in a life-course study, Proc. Natl. Acad. Sci. U. S. A., 104, 1319, 10.1073/pnas.0610362104 · DOI · Paper page
  28. De Miguel, 2017, Early life stress induces immune priming in kidneys of adult male rats, APSselect, 4, F343
  29. Dong, 2019, Stabilization of Brain Mast Cells Alleviates LPS-Induced Neuroinflammation by Inhibiting Microglia Activation, Front. Cell. Neurosci., 13, 191, 10.3389/fncel.2019.00191 · DOI
  30. Duffy, 2018, Early life adversity and health-risk behaviors: proposed psychological and neural mechanisms, Ann. N. Y. Acad. Sci., 1428, 151, 10.1111/nyas.13928 · DOI · Paper page
  31. Edwards, 2003, Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: results from the adverse childhood experiences study, Am. J. Psychiatry, 160, 1453, 10.1176/appi.ajp.160.8.1453 · DOI · Paper page
  32. Eide, 2018, Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes, Sci. Rep., 8, 7194, 10.1038/s41598-018-25666-4 · DOI · Paper page
  33. Estienne, 2010, Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides, Gut, 59, 744, 10.1136/gut.2009.190728 · DOI
  34. Finn, 2013, Twenty-first century mast cell stabilizers, Br. J. Pharmacol., 170, 23, 10.1111/bph.12138 · DOI
  35. Foley, 2014, Pre- and Neonatal Exposure to Lipopolysaccharide or the Enteric Metabolite, Propionic Acid, Alters Development and Behavior in Adolescent Rats in a Sexually Dimorphic Manner, PLOS ONE, 9, 10.1371/journal.pone.0087072 · DOI
  36. Forsythe, 2019, Mast Cells in Neuroimmune Interactions, Trends Neurosci., 42, 43, 10.1016/j.tins.2018.09.006 · DOI
  37. Galli, 2015, Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo, Adv. Immunol., 126, 45, 10.1016/bs.ai.2014.11.002 · DOI · Paper page
  38. Ganguly, 2019, Effects of early life stress on cocaine conditioning and AMPA receptor composition are sex-specific and driven by TNF, Brain. Behav. Immun., 78, 41, 10.1016/j.bbi.2019.01.006 · DOI
  39. Godoy, 2021, Association of Adverse Childhood Experiences With Cardiovascular Disease Later in Life: A Review, JAMA Cardiol., 6, 228, 10.1001/jamacardio.2020.6050 · DOI
  40. González-de-Olano, 2018, Mast Cells as Key Players in Allergy and Inflammation, J. Investig. Allergol. Clin. Immunol., 28, 365, 10.18176/jiaci.0327 · DOI
  41. Goodwill, 2019, Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model, Neuropsychopharmacology, 44, 711, 10.1038/s41386-018-0195-5 · DOI
  42. Goodwin, 2004, Association between childhood trauma and physical disorders among adults in the United States, Psychol. Med., 34, 509, 10.1017/S003329170300134X · DOI
  43. Greenberg, 1983, A novel cell-to-cell interaction between mast cells and other cell types, Exp. Cell Res., 147, 1, 10.1016/0014-4827(83)90265-3 · DOI
  44. Gutiérrez-Menéndez, 2020, How Does Maternal Separation Affect the Cerebellum? Assessment of the Oxidative Metabolic Activity and Expression of the c-Fos Protein in Male and Female Rats, The Cerebellum, 19, 68, 10.1007/s12311-019-01087-5 · DOI
  45. Herisson, 2018, Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration, Nat. Neurosci., 21, 1209, 10.1038/s41593-018-0213-2 · DOI · Paper page
  46. Hu, 2020, Meningeal lymphatic vessels regulate brain tumor drainage and immunity, Cell Res., 30, 229, 10.1038/s41422-020-0287-8 · DOI
  47. Huber, 2019, Regulation of the pleiotropic effects of tissue-resident mast cells, J. Allergy Clin. Immunol., 144, S31, 10.1016/j.jaci.2019.02.004 · DOI
  48. Jenne, 1991, Angiotensin II-forming heart chymase is a mast-cell-specific enzyme, Biochem. J., 276, 567, 10.1042/bj2760567 · DOI
  49. Jones, 2016, Psychosocial Vulnerability and Early Life Adversity as Risk Factors for Central Sensitivity Syndromes, Curr. Rheumatol. Rev., 12, 140, 10.2174/1573397112666151231113438 · DOI · Paper page
  50. Kessler, 2003, Epidemiology of women and depression, J. Affect. Disord., 74, 5, 10.1016/S0165-0327(02)00426-3 · DOI · Paper page
  51. Kinkead, 2010, Neonatal maternal separation and neuroendocrine programming of the respiratory control system in rats, Biol. Psychol., 84, 26, 10.1016/j.biopsycho.2009.09.001 · DOI
  52. Klein, 2016, Sex differences in immune responses, Nat. Rev. Immunol., 16, 626, 10.1038/nri.2016.90 · DOI · Paper page
  53. Koroleva, 2019, Meningeal Mast Cells Contribute to ATP-Induced Nociceptive Firing in Trigeminal Nerve Terminals: Direct and Indirect Purinergic Mechanisms Triggering Migraine Pain, Front. Cell. Neurosci., 13, 10.3389/fncel.2019.00195 · DOI
  54. Kunder, 2011, Mast cell modulation of the vascular and lymphatic endothelium, Blood, 118, 5383, 10.1182/blood-2011-07-358432 · DOI
  55. Lasselin, 2018, Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans, Front. Neuroendocrinol., 50, 91, 10.1016/j.yfrne.2018.06.005 · DOI · Paper page
  56. Lee, 2019, The Role of Inflammation in Depression and Fatigue, Front. Immunol., 10, 10.3389/fimmu.2019.01696 · DOI
  57. Lenz, 2018, Mast Cells in the Developing Brain Determine Adult Sexual Behavior, J. Neurosci., 38, 8044, 10.1523/JNEUROSCI.1176-18.2018 · DOI · Paper page
  58. Levy, 2009, Migraine pain, meningeal inflammation, and mast cells, Curr. Pain Headache Rep., 13, 237, 10.1007/s11916-009-0040-y · DOI
  59. Levy, 2007, Mast cell degranulation activates a pain pathway underlying migraine headache, PAIN, 130, 166, 10.1016/j.pain.2007.03.012 · DOI
  60. Li, 2016, Endoplasmic reticulum stress is involved in the colonic epithelium damage induced by maternal separation, J. Pediatr. Surg., 51, 1001, 10.1016/j.jpedsurg.2016.02.073 · DOI
  61. Liu, 2018, Sucrose preference test for measurement of stress-induced anhedonia in mice, Nat. Protoc., 13, 1686, 10.1038/s41596-018-0011-z · DOI · Paper page
  62. Loucks, 2010, Life course socioeconomic position is associated with inflammatory markers: The Framingham Offspring Study, Soc. Sci. Med., 71, 187, 10.1016/j.socscimed.2010.03.012 · DOI
  63. Louveau, 2015, Structural and functional features of central nervous system lymphatics, Nature, 523, 337, 10.1038/nature14432 · DOI · Paper page
  64. Louveau, 2018, CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature, Nat. Neurosci., 21, 1380, 10.1038/s41593-018-0227-9 · DOI · Paper page
  65. Mackey, 2016, Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress, Biol. Sex Differ., 7, 60, 10.1186/s13293-016-0113-7 · DOI
  66. Mackey, 2020, Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood, Proc. Natl. Acad. Sci., 117, 23751, 10.1073/pnas.1915075117 · DOI
  67. Martinez, 2018, Circulating cytokine levels are associated with symptoms of depression and anxiety among people with alcohol and drug use disorders, J. Neuroimmunol., 318, 80, 10.1016/j.jneuroim.2018.02.011 · DOI
  68. Meyer, 2017, Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth, Sci. Rep., 7, 45106, 10.1038/srep45106 · DOI · Paper page
  69. Moon, 2014, Mast Cell Mediators: Their Differential Release and the Secretory Pathways Involved, Front. Immunol., 5, 10.3389/fimmu.2014.00569 · DOI
  70. Mourlon, 2010, Maternal deprivation induces depressive-like behaviours only in female rats, Behav. Brain Res., 213, 278, 10.1016/j.bbr.2010.05.017 · DOI
  71. Nakae, 2005, Mast cells enhance T cell activation: Importance of mast cell-derived TNF, Proc. Natl. Acad. Sci., 102, 6467, 10.1073/pnas.0501912102 · DOI
  72. Noseda, 2019, Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache, J. Neurosci. Off. J. Soc. Neurosci., 39, 1867, 10.1523/JNEUROSCI.2153-18.2018 · DOI
  73. Nurkhametova, 2020, Mast Cell Mediators as Pain Triggers in Migraine: Comparison of Histamine and Serotonin in the Activation of Primary Afferents in the Meninges in Rats, Neurosci. Behav. Physiol., 50, 900, 10.1007/s11055-020-00983-2 · DOI
  74. Nusslock, 2016, Early-Life Adversity and Physical and Emotional Health Across the Lifespan: A Neuroimmune Network Hypothesis, Biol. Psychiatry, 80, 23, 10.1016/j.biopsych.2015.05.017 · DOI · Paper page
  75. Peña, 2019, Early life stress alters transcriptomic patterning across reward circuitry in male and female mice, Nat. Commun., 10, 10.1038/s41467-019-13085-6 · DOI · Paper page
  76. Piliponsky, 2012, The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis, Am. J. Pathol., 181, 875, 10.1016/j.ajpath.2012.05.013 · DOI
  77. Pinke, 2020, Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?, Neurotherapeutics, 17, 218, 10.1007/s13311-019-00775-8 · DOI
  78. Pohl, 2017, Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity, Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc., 29
  79. Reynolds, 2015, Prevalence of psychiatric disorders in U.S. older adults: findings from a nationally representative survey, World Psychiatry, 14, 74, 10.1002/wps.20193 · DOI
  80. Rich-Edwards, 2010, Abuse in childhood and adolescence as a predictor of type 2 diabetes in adult women, Am. J. Prev. Med., 39, 529, 10.1016/j.amepre.2010.09.007 · DOI
  81. Rincel, 2019, Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner, Brain. Behav. Immun., 80, 179, 10.1016/j.bbi.2019.03.006 · DOI
  82. Rovere, 2009, Phagocytosis of Cancer Cells by Mast Cells in Breast Cancer, Anticancer Res., 29, 3157
  83. Russi, 2016, Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity, J. Autoimmun., 73, 100, 10.1016/j.jaut.2016.06.015 · DOI
  84. Russi, 2018, Mast cell inflammasome activity in the meninges regulates EAE disease severity, Clin. Immunol., 189, 14, 10.1016/j.clim.2016.04.009 · DOI
  85. Sayed, 2010, Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?, J. Immunol., 184, 6891, 10.4049/jimmunol.1000126 · DOI
  86. Schmahmann, 1998, Dysmetria of thought: clinical consequences of cerebellar dysfunction on cognition and affect, Trends Cogn. Sci., 2, 362, 10.1016/S1364-6613(98)01218-2 · DOI
  87. Schmahmann, 2000, The role of the cerebellum in affect and psychosis, J. Neurolinguistics, 13, 189, 10.1016/S0911-6044(00)00011-7 · DOI
  88. Shibuya, A., Nakahashi-Oda, C. & Tahara-Hanaoka, S. Inhibitory Immunoreceptors on Mast Cells in Allergy and Inflammation. in Innovative Medicine: Basic Research and Development (eds. Nakao, K., Minato, N. & Uemoto, S.) (Springer, 2015). · DOI
  89. Skaper, 2017, Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons, Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry, 23, 478
  90. Song, 2020, VEGF-C-driven lymphatic drainage enables brain tumor immunosurveillance, Nature, 577, 689, 10.1038/s41586-019-1912-x · DOI
  91. Spanos, 1997, Stress-induced bladder mast cell activation: implications for interstitial cystitis, J. Urol., 157, 669, 10.1016/S0022-5347(01)65247-9 · DOI
  92. Spitzer, 2012, Childhood Trauma in Multiple Sclerosis: A Case-Control Study, Psychosom. Med., 74, 312, 10.1097/PSY.0b013e31824c2013 · DOI
  93. Stephan, 2002, Postnatal maternal deprivation aggravates experimental autoimmune encephalomyelitis in adult Lewis rats: reversal by chronic imipramine treatment, Int. J. Dev. Neurosci., 20, 125, 10.1016/S0736-5748(02)00007-2 · DOI
  94. Steven, 2019, Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease, Oxid. Med. Cell. Longev., 2019, 10.1155/2019/7092151 · DOI
  95. Talley, 1994, Gastrointestinal tract symptoms and self-reported abuse: a population-based study, Gastroenterology, 107, 1040, 10.1016/0016-5085(94)90228-3 · DOI
  96. Tashiro, 2006, Brain histamine H1 receptor occupancy of orally administered antihistamines measured by positron emission tomography with 11C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen, Br. J. Clin. Pharmacol., 61, 16, 10.1111/j.1365-2125.2005.02514.x · DOI
  97. Theoharides, 1995, Stress-induced intracranial mast cell degranulation: a corticotropin-releasing hormone-mediated effect, Endocrinology, 136, 5745, 10.1210/endo.136.12.7588332 · DOI · Paper page
  98. Tottenham, 2011, Elevated amygdala response to faces following early deprivation, Dev. Sci., 14, 190, 10.1111/j.1467-7687.2010.00971.x · DOI · Paper page
  99. Troubat, 2021, Neuroinflammation and depression: A review, Eur. J. Neurosci., 53, 151, 10.1111/ejn.14720 · DOI · Paper page
  100. van Harmelen, 2013, Enhanced amygdala reactivity to emotional faces in adults reporting childhood emotional maltreatment, Soc. Cogn. Affect. Neurosci., 8, 362, 10.1093/scan/nss007 · DOI
  101. Viola, 2019, Acute neuroinflammation elicited by TLR-3 systemic activation combined with early life stress induces working memory impairments in male adolescent mice, Behav. Brain Res., 376, 10.1016/j.bbr.2019.112221 · DOI
  102. Walsh, 2018, Regional mechanical and biochemical properties of the porcine cortical meninges, Acta Biomater., 80, 237, 10.1016/j.actbio.2018.09.004 · DOI
  103. Wang, 2017, Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice, Int. J. Dev. Neurosci., 62, 37, 10.1016/j.ijdevneu.2017.07.007 · DOI
  104. Wigger, 2020, Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice, Oxid. Med. Cell. Longev., 2020, 10.1155/2020/4309605 · DOI
  105. Wilhelm, 2005, Central nervous system neurons acquire mast cell products via transgranulation, Eur. J. Neurosci., 22, 2238, 10.1111/j.1460-9568.2005.04429.x · DOI
  106. Williams, 2019, Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress, Biol. Psychiatry
  107. Zhao, 2022, Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma, J. Allergy Clin. Immunol., 149, 718, 10.1016/j.jaci.2021.07.020 · DOI
  108. Zhu, 2002, Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons, Nat. Neurosci., 5, 719, 10.1038/nn881 · DOI
  109. Zhu, 2004, Temporal regulation of cerebellar EGL migration through a switch in cellular responsiveness to the meninges, Dev. Biol., 267, 153, 10.1016/j.ydbio.2003.10.037 · DOI
  110. Zhuang, 1996, Brain mast cell degranulation regulates blood-brain barrier, J. Neurobiol., 31, 393, 10.1002/(SICI)1097-4695(199612)31:4<393::AID-NEU1>3.0.CO;2-4 · DOI

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Metadata

Authors
Duque-Wilckens, N., Teis, R., Sarno, E., Stoelting, F., Khalid, S., Dairi, Z., Douma, A., Maradiaga, N., Hench, S., Dharshika, C. D., Thelen, K. M., Gulbransen, B., Robison, A. J., & Moeser, A. J.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2022-07
Volume
103
Pages
73-84
ISSN
0889-1591
DOI
10.1016/j.bbi.2022.03.009
PMC
PMC9149134
Cited by
27
References
18
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Early life adversity drives sex‐specific anhedonia and meningeal immune gene expression through mast cell activation. https://app.cochat.ai/papers/10.1016/j.bbi.2022.03.009
The paper
Duque-Wilckens, N., Teis, R., Sarno, E., Stoelting, F., Khalid, S., Dairi, Z., Douma, A., Maradiaga, N., Hench, S., Dharshika, C. D., Thelen, K. M., Gulbransen, B., Robison, A. J., & Moeser, A. J. (2022). Early life adversity drives sex‐specific anhedonia and meningeal immune gene expression through mast cell activation. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2022.03.009