The DOI matches its Crossref record; 261 of the 261 references it cites were found in a registry or an index.
Immune responses to implants – A review of the implications for the design of immunomodulatory biomaterials
Abstract
A key for long-term survival and function of biomaterials is that they do not elicit a detrimental immune response. As biomaterials can have profound impacts on the host immune response the concept emerged to design biomaterials that are able to trigger desired immunological outcomes and thus support the healing process. However, engineering such biomaterials requires an in-depth understanding of the host inflammatory and wound healing response to implanted materials. One focus of this review is to outline the up-to-date knowledge on immune responses to biomaterials. Understanding the complex interactions of host response and material implants reveals the need for and also the potential of "immunomodulating" biomaterials. Based on this knowledge, we discuss strategies of triggering appropriate immune responses by functional biomaterials and highlight recent approaches of biomaterials that mimic the physiological extracellular matrix and modify cellular immune responses.
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“Within two days of implantation the initial wave of neutrophils has completely disappeared to give way to a population of macrophages (Anderson et al., 2008; Franz et al., 2011), which self-sustains itself by continuously proliferating and releasing chemoattractants that recruit further macrophages.”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Franz et al., 2011
In the citing paper
“Upon surgical implantation, it has been shown that the initial M1 response is responsible for recruiting inflammatory cells to the site of injury and for instigating the ensuing foreign body response [5,86,91], which are necessary events for wound healing.”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [86]
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Metadata
- Authors
- Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C.
- Affiliations
- Leipzig University (DE)
- University Hospital Carl Gustav Carus (DE)
- Max Bergmann Center of Biomaterials (DE)
- Corresponding author
- Franz, Sandra
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 32
- Issue
- 28
- Pages
- 6692-6709
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2031041031
- Semantic Scholar
- 49c89551d546a011dda778f4bbdb55013b0c6750
- Cited by
- 1,391
- References
- 261
- Citations by year
- 2026: 68 · 2025: 97 · 2024: 99 · 2023: 97 · 2022: 116 · 2021: 145 · 2020: 136 · 2019: 114 · 2018: 100 · 2017: 103 · 2016: 92 · 2015: 77 · 2014: 72 · 2013: 42 · 2012: 25
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- immune response to implants, immunomodulatory biomaterials, biomaterial design, host inflammatory response, wound healing, extracellular matrix mimics, implant biocompatibility
- MeSH terms
- Biocompatible Materials, Complement Activation, Extracellular Matrix, Foreign-Body Reaction, Humans, Immune System, Immunologic Factors, Inflammation, Wound Healing, Prostheses and Implants
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