Cited by 149Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 66 of the 68 references it cites were found in a registry or an index.

The Beta-1 Adrenergic Antagonist, Betaxolol, Improves Working Memory Performance in Rats and Monkeys

Ramos, Brian P., Colgan, Lesley, Nou, Eric, Ovadia, Shira, Wilson, Steven R., Arnsten, Amy F.T.·2005·Biological Psychiatry

Abstract

Background Previous studies have indicated that beta adrenergic receptor stimulation has no effect on the cognitive functioning of the prefrontal cortex (PFC). Blockade of beta-1 and beta-2 receptors in the PFC with the mixed beta-1/beta-2 antagonist, propanolol, had no effect on spatial working memory performance. However, more selective blockade of beta-1 or beta-2 receptors might show efficacy if the two receptors have opposite effects on PFC function. The current study examined the effects of the selective beta-1 antagonist, betaxolol, on working memory in rats and monkeys. Methods In rats, betaxolol (.0011-1.11 microg/.5 microL) was infused into the PFC 5 min before delayed alternation testing. Monkeys were systemically injected with betaxolol (.0000011-.11 mg/kg) 2 hours before delayed response testing. Results Betaxolol produced a dose-related improvement in working memory performance following either direct PFC infusion in rats, or systemic administration in monkeys. However, some aged monkeys developed serious pancreatic problems over the course of this study. Conclusions These findings suggest that endogenous activation of the beta-1 adrenergic receptor impairs PFC cognitive function. These results may have therapeutic relevance to post-traumatic stress disorder or other disorders with excessive noradrenergic activity and PFC dysfunction. Pancreatic side effects in aged subjects taking betaxolol warrants further investigation.

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Crossref · 10.1016/j.biopsych.2005.05.022

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Research works printed but not linked: 4

  1. Benn, 1992, Glucose turnover in type I diabetic subjects during exercise. Effect of selective and nonselective beta-blockade and insulin withdrawal, Diabetes Care, 15, 1721, 10.2337/diacare.15.11.1721 · DOI
  2. Lupien, 1999, Working memory is more sensitive than declarative memory to the acute effects of corticosteroids, Behavioral Neuroscience, 113, 420, 10.1037/0735-7044.113.3.420 · DOI · Paper page
  3. Saunders, 1981, A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia, European Journal of Clinical Pharmacology, 21, 177, 10.1007/BF00627917 · DOI
  4. Sinclair, 1990, Betaxolol and glucose-insulin relationships, British Journal of Clinical Pharmacology, 30, 699, 10.1111/j.1365-2125.1990.tb03838.x · DOI

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Metadata

Authors
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T.
Affiliations
Yale University (US)
Corresponding author
Arnsten, Amy F.T.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-12
Volume
58
Issue
11
Pages
894-900
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2076484851
Cited by
147
References
68
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 7
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (R37AG006036, R37 AG06036)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
betaxolol, beta1-adrenergic receptor, working memory, prefrontal cortex, cognitive function, noradrenergic activity, post-traumatic stress disorder, propranolol, delayed alternation, delayed response, aging
MeSH terms
Adrenergic beta-Antagonists, Animals, Attention, Cognition, Dose-Response Relationship, Drug, Hypnotics and Sedatives, Macaca mulatta, Male, Memory, Short-Term, Microinjections, Pancreatic Diseases, Psychomotor Performance, Stereotaxic Techniques, Betaxolol, Prefrontal Cortex, Maze Learning, Rats, Adrenergic beta-1 Receptor Antagonists

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