Functional Neuroanatomical Differences Between Adults and School-Age Children in the Processing of Single Words
Abstract
A critical issue in developmental cognitive neuroscience is the extent to which the functional neuroanatomy underlying task performance differs in adults and children. Direct comparisons of brain activation in the left frontal and extrastriate cortex were made in adults and children (aged 7 to 10 years) performing single-word processing tasks with visual presentation; differences were found in circumscribed frontal and extrastriate regions. Conceivably, these differences could be attributable exclusively to performance discrepancies; alternatively, maturational differences in functional neuroanatomy could exist despite similar performance. Some of the brain regions examined showed differences attributable to age independent of performance, suggesting that maturation of the pattern of regional activations for these tasks is incomplete at age 10.
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Understanding normal brain maturation is essential for understanding neurodevelopmental disorders.
“understanding normal brain maturation is essential for understanding neurodevelopmental disorders (4, 5).”
From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [5]
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- Authors
- Schlaggar, B. L., Brown, T. T., Lugar, H. M., Visscher, K. M., Miezin, F. M., & Petersen, S. E.
- Affiliations
- Washington University in St. Louis (US)
- Department of Psychology,
- Department of Neurology,
- Department of Anatomy and Neurobiology,
- Corresponding author
- Schlaggar, Bradley L.
- ORCID
- Venue
- Science
- Published
- 2002-05-24
- Volume
- 296
- Issue
- 5572
- Pages
- 1476-1479
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020497215
- Cited by
- 451
- References
- 27
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 21 · 2017: 13 · 2016: 14 · 2015: 20 · 2014: 21 · 2013: 28 · 2012: 24
- FWCI
- 60.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS55582, NS51281, NS-32979, R01NS032979)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- single word processing, brain maturation, developmental cognitive neuroscience, children versus adults, left frontal cortex, extrastriate cortex, regional brain activation, reading
- MeSH terms
- Adolescent, Adult, Aging, Analysis of Variance, Brain, Brain Mapping, Child, Cognition, Female, Frontal Lobe, Humans, Language, Magnetic Resonance Imaging, Male, Mental Processes
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