Methylphenidate improves diminished error and feedback sensitivity in ADHD: an evoked heart rate analysis
Abstract
Attention Deficit Hyperactivity Disorder (ADHD) is a developmental disorder that has previously been related to a decreased sensitivity to errors and feedback. Supplementary to the traditional performance measures, this study uses autonomic measures to study this decreased sensitivity in ADHD and the modulating effects of medication. Children with ADHD, on and off Methylphenidate (Mph), and typically developing (TD) children performed a selective attention task with three feedback conditions: reward, punishment and no feedback. Evoked Heart Rate (EHR) responses were computed for correct and error trials. All groups performed more efficiently with performance feedback than without. EHR analyses, however, showed that enhanced EHR decelerations on error trials seen in TD children, were absent in the medication-free ADHD group for all feedback conditions. The Mph-treated ADHD group showed 'normalised' EHR decelerations to errors and error feedback, depending on the feedback condition. This study provides further evidence for a decreased physiological responsiveness to errors and error feedback in children with ADHD and for a modulating effect of Mph.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
All groups (controls, ADHD-unmedicated and ADHD-medicated) were more accurate and gave slower responses in the feedback blocks compared with no feedback, and showed similar post-error slowing, while stimulus-locked HR decelerations were greater on error trials than correct trials in controls and medicated-ADHD, but not in unmedicated ADHD.
“Also, all groups (controls, ADHD-unmedicated and ADHD-medicated) were more accurate and gave slower responses in the feedback blocks compared with no feedback, and show similar post-error slowing, while stimulus-locked HR decelerations were greater on error trials than correct trials in controls and medicated-ADHD, but not in unmedicated ADHD.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Groen et al., 2009
The only study investigating error monitoring found signs of hypoactivation of the ANS in ADHD during a task that required participants to report the global or local shape in a global/local array.
“The only study investigating error monitoring found signs of hypoactivation of the ANS in ADHD during a task that required participants to report the global or local shape in a global/local array, interpreted as reduced sensitivity to error processing (Groen et al., 2009).”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Groen et al., 2009
Groen et al. (2009) found HR decelerations to errors and in response to feedback after errors in both children with ADHD on MPH and controls, while these decelerations were not present when the ADHD children were unmedicated.
“Groen et al. (2009) measured the effect of MPH on HR measures during a cognitive task, and found HR decelerations to errors and in response to feedback after errors in both children with ADHD on MPH and controls, while these decelerations were not present when the ADHD children were unmedicated.”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Groen et al. (2009)
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Applied Multivariate Statistics for the Social Sciences
Stevens, J. P. (2012) · Routledge eBooks · doi:10.4324/9780203843130 · Cited by 10,652 · see citing works
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505 · see citing works
A neural system for error detection and compensation
Gehring, W. J., Goss, B., Coles, M. G. H., Meyer, D. E., & Donchin, E. (1993) · Psychological Science · doi:10.1111/j.1467-9280.1993.tb00586.x · Cited by 2,862 · see citing works
Falkenstein, M., Hohnsbein, J., Hoormann, J., & Blanke, L. (1991) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(91)90062-9 · Cited by 1,706 · see citing works
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition
Sonuga-Barke, E. J. S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00432-6 · Cited by 901 · see citing works
The cognitive-energetic model: an empirical approach to attention-deficit hyperactivity disorder
Sergeant, J. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00060-3 · Cited by 645 · see citing works
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580 · see citing works
Hyperactivity and Delay Aversion—I. The Effect of Delay on Choice
Sonuga‐Barke, E. J. S., Taylor, E., Sembi, S., & Smith, J. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb00874.x · Cited by 578 · see citing works
Hajcak, G., McDonald, N., & Simons, R. F. (2003) · Psychophysiology · doi:10.1111/1469-8986.00107 · Cited by 553 · see citing works
The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal
Luman, M., Oosterlaan, J., & Sergeant, J. A. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.11.001 · Cited by 541 · see citing works
Fundamentals of Attention-Deficit/Hyperactivity Disorder: Circuits and Pathways
Arnsten, A. F. T. (2006) · The Primary Care Companion to The Journal of Clinical Psychiatry · Cited by 380 · see citing works
Measurement and analysis methods of heart rate and respiration for use in applied environments
Mulder, L. J. M. (1992) · Biological Psychology · doi:10.1016/0301-0511(92)90016-n · Cited by 318 · see citing works
Self-citationDrug-induced stimulation and suppression of action monitoring in healthy volunteers
de Bruijn, E. R. A., Hulstijn, W., Verkes, R. J., Ruigt, G. S. F., & Sabbe, B. G. C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1915-6 · Cited by 282 · see citing works
The neuropsychopharmacology of attention-deficit/hyperactivity disorder
Pliszka, S. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.026 · Cited by 276 · see citing works
Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children
Tannock, R., Schachar, R. J., & Logan, G. D. (1995) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01447091 · Cited by 226 · see citing works
Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder
Schachar, R. J., Chen, S., Logan, G. D., Ornstein, T. J., Crosbie, J., Ickowicz, A., & Pakulak, A. (2004) · Journal of Abnormal Child Psychology · doi:10.1023/b:jacp.0000026142.11217.f2 · Cited by 221 · see citing works
Attention Deficit Disorder With Hyperactivity: A Specific Hypothesis of Reward Dysfunction
HAENLEIN, M., & CAUL, W. F. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198705000-00014 · Cited by 213 · see citing works
van Meel, C. S., Heslenfeld, D. J., Oosterlaan, J., & Sergeant, J. A. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.05.011 · Cited by 187 · see citing works
Motivational Effects on Inhibitory Control in Children With ADHD
SLUSAREK, M., VELLING, S., BUNK, D., & EGGERS, C. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200103000-00016 · Cited by 184 · see citing works
ERP correlates of impaired error monitoring in children with ADHD
Wiersema, J. R., van der Meere, J. J., & Roeyers, H. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0276-6 · Cited by 166 · see citing works
Effects of reward and nonreward on frustration and attention in attention deficit disorder
Douglas, V. I., & Parry, P. A. (1994) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf02168075 · Cited by 155 · see citing works
Groen, Y., Wijers, A. A., Mulder, L. J. M., Waggeveld, B., Minderaa, R. B., & Althaus, M. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.08.004 · Cited by 153 · see citing works
Self-citationPsychophysiological response of ADHD children to reward and extinction
IABONI, F., DOUGLAS, V. I., & DITTO, B. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02422.x · Cited by 146 · see citing works
CLINICAL USE OF RATING SCALES IN DIAGNOSIS AND TREATMENT OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
Conners, C. K. (1999) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70159-0 · Cited by 135 · see citing works
Yovel, G., Yovel, I., & Levy, J. (2001) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.27.6.1369 · Cited by 133 · see citing works
What happens after a hyperactive child commits an error?
Sergeant, J. A., & van der Meere, J. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90058-3 · Cited by 121 · see citing works
Sensitivity to interference and response contingencies in attention-deficit/hyperactivity disorder
Crone, E. A., Richard Jennings, J., & Van Der Molen, M. W. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00115 · Cited by 119 · see citing works
Carlson, C. L., & Tamm, L. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.1.73 · Cited by 117 · see citing works
van Meel, C. S., Oosterlaan, J., Heslenfeld, D. J., & Sergeant, J. A. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.03.018 · Cited by 115 · see citing works
Jonkman, L. M., van Melis, J. J. M., Kemner, C., & Markus, C. R. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.08.004 · Cited by 111 · see citing works
Do High Doses of Stimulants Impair Flexible Thinking in Attention-Deficit Hyperactivity Disorder?
DOUGLAS, V. I., BARR, R. G., DESILETS, J., & SHERMAN, E. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199507000-00011 · Cited by 103 · see citing works
Rapport, M. D., Tucker, S. B., DuPaul, G. J., Merlo, M., & Stoner, G. D. (1986) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00915440 · Cited by 100 · see citing works
Wisconsin Card Sorting in adolescents: analysis of performance, response times and heart rate
Somsen, R. J. M., van der Molen, M. W., Jennings, J. R., & van Beek, B. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00030-5 · Cited by 79 · see citing works
Developmental Change in Feedback Processing as Reflected by Phasic Heart Rate Changes.
Crone, E. A., Jennings, J. R., & van der Molen, M. W. (2004) · Developmental Psychology · doi:10.1037/0012-1649.40.6.1228 · Cited by 78 · see citing works
Effects of Reward and Response Cost on the Performance and Motivation of Children with ADHD
Carlson, C. L., Mann, M., & Alexander, D. K. (2000) · Cognitive Therapy and Research · doi:10.1023/a:1005455009154 · Cited by 77 · see citing works
de Sonneville, L. M. J., Njiokiktjien, C., & Bos, H. (1994) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639408402700 · Cited by 76 · see citing works
Cardiac concomitants of feedback processing
Crone, E. A., van der Veen, F. M., van der Molen, M. W., Somsen, R. J. M., van Beek, B., & Jennings, J. R. (2003) · Biological Psychology · doi:10.1016/s0301-0511(03)00106-6 · Cited by 76 · see citing works
Jadad, A. R., Booker, L., Gauld, M., Kakuma, R., Boyle, M., Cunningham, C. E., Kim, M., & Schachar, R. J. (1999) · The Canadian Journal of Psychiatry · doi:10.1177/070674379904401009 · Cited by 74 · see citing works
Groen, Y., Wijers, A. A., Mulder, L. J. M., Minderaa, R. B., & Althaus, M. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.07.006 · Cited by 66 · see citing works
Self-citationCrone, E. A., Somsen, R. J. M., Zanolie, K., & van der Molen, M. W. (2006) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2006.03.007 · Cited by 65 · see citing works
Cardiac timing and the central regulation of action
Jennings, R., & van der Molen, M. W. (2002) · Psychological Research · doi:10.1007/s00426-002-0106-5 · Cited by 63 · see citing works
Krusch, D. A., Klorman, R., Brumaghim, J. T., Fitzpatrick, P. A., Borgstedt, A. D., & Strauss, J. (1996) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01670104 · Cited by 56 · see citing works
Modulation of Response Timing in ADHD, Effects of Reinforcement Valence and Magnitude
Luman, M., Oosterlaan, J., & Sergeant, J. A. (2008) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-007-9190-8 · Cited by 52 · see citing works
Heart rate and reinforcement sensitivity in ADHD
Luman, M., Oosterlaan, J., Hyde, C., Van Meel, C. S., & Sergeant, J. A. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01769.x · Cited by 48 · see citing works
van der Veen, F. M., van der Molen, M. W., Crone, E. A., & Jennings, J. R. (2003) · Biological Psychology · doi:10.1016/j.biopsycho.2003.07.003 · Cited by 46 · see citing works
Cardiac concomitants of performance monitoring: Context dependence and individual differences
Crone, E. A., Bunge, S. A., de Klerk, P., & van der Molen, M. W. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.01.009 · Cited by 30 · see citing works
van der Veen, F. M., Mies, G. W., van der Molen, M. W., & Evers, E. A. T. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1176-x · Cited by 24 · see citing works
Methylphenidate's effects on paired‐associate learning and event‐related potentials of young adults
Brumaghim, J. T., & Klorman, R. (1998) · Psychophysiology · doi:10.1111/1469-8986.3510073 · Cited by 20 · see citing works
Appropriateness of Psychostimulant Prescription to Children: Theoretical and Empirical Perspectives
Miller, A. R. (1999) · The Canadian Journal of Psychiatry · doi:10.1177/070674379904401008 · Cited by 18 · see citing works
Altered Response Evaluation: Monitoring of Late Responses After Administration of D-Amphetamine
de Bruijn, E. R. A., Hulstijn, W., Verkes, R. J., Ruigt, G. S. F., & Sabbe, B. G. C. (2005) · Journal of Psychophysiology · doi:10.1027/0269-8803.19.4.311 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bellato, A., Arora, I., Hollis, C., & Groom, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.001 · Cited by 172 · see citing works
Rubia, K., Halari, R., Mohammad, A.-M., Taylor, E., & Brammer, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.018 · Cited by 171 · see citing works
Risky behavior in gambling tasks in individuals with ADHD–a systematic literature review
Groen, Y., Gaastra, G. F., Lewis-Evans, B., & Tucha, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074909 · Cited by 127 · see citing works
Self-citationEpstein, J. N., Brinkman, W. B., Froehlich, T., Langberg, J. M., Narad, M. E., Antonini, T. N., Shiels, K., Simon, J. O., & Altaye, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.243 · Cited by 78 · see citing works
Methylphenidate Effects on Prefrontal Functioning During Attentional-Capture and Response Inhibition
Pauls, A. M., O'Daly, O. G., Rubia, K., Riedel, W. J., Williams, S. C. R., & Mehta, M. A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.028 · Cited by 57 · see citing works
- Authors
- Groen, Y., Mulder, L. J. M., Wijers, A. A., Minderaa, R. B., & Althaus, M.
- Affiliations
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Corresponding author
- Groen, Yvonne
- ORCID
- Groen, Yvonne
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 82
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0301-0511 (ISSN-L)
- OpenAlex
- W2031797327
- Cited by
- 27
- References
- 52
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, methylphenidate, error sensitivity, feedback sensitivity, reward feedback, selective attention, children, stimulant medication effects
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Attention, Attention Deficit Disorder with Hyperactivity, Child, Electrocardiography, Feedback, Female, Heart Rate, Humans, Male, Methylphenidate, Neuropsychological Tests, Photic Stimulation, Reaction Time
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
