Cited by 164Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsTreatment of Major Depression

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Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment

Huang, Yu-Yuan, Gan, Yi-Han, Yang, Liu, Cheng, Wei, Yu, Jin-Tai·2024·Biological Psychiatry

DOI 10.1016/j.biopsych.2023.10.008

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Abstract

Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past decades, a link between the 2 disease entities has received extensive acknowledgment, yet the complex nature of this relationship demands further clarification. Some evidence indicates that midlife depression may be an AD risk factor, while a chronic course of depression in late life may be a precursor to or symptom of dementia. Recently, multiple pathophysiological mechanisms have been proposed to underlie the bidirectional relationship between depression and AD, including genetic predisposition, immune dysregulation, accumulation of AD-related biomarkers (e.g., amyloid-β and tau), and alterations in brain structure. Accordingly, numerous therapeutic approaches, such as pharmacology treatments, psychotherapy, and lifestyle interventions, have been suggested as potential means of interfering with these pathways. However, the current literature on this topic remains fragmented and lacks a comprehensive review characterizing the association between depression and AD. In this review, we aim to address these gaps by providing an overview of the co-occurrence and temporal relationship between depression and AD, as well as exploring their underlying mechanisms. We also examine the current therapeutic regimens for depression and their implications for AD management and outline key challenges facing the field.

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Authors: Huang, Y.-Y., Gan, Y.-H., Yang, L., Cheng, W., & Yu, J.-T.
Affiliations: Shanghai Medical College of Fudan University (CN)
Corresponding author: Yu, Jin-Tai
ORCID: Cheng, Wei
Yu, Jin-Tai
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2024-06
Volume: 95
Issue: 11
Pages: 992-1005
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2023.10.008
OpenAlex: W4387802230
Cited by: 164
References: 133
Citations by year: 2026: 63 · 2025: 83 · 2024: 18
FWCI: 7.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: depression, Alzheimer's disease, dementia, geriatric depression, bidirectional relationship, amyloid-beta, tau protein, immune dysregulation, genetic susceptibility, brain structure, pharmacotherapy, psychotherapy, lifestyle intervention, risk factors
MeSH terms: Alzheimer Disease, Antidepressive Agents, Depression, Depressive Disorder, Humans

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Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment

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