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Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Walgrave, Hannah, Balusu, Sriram, Snoeck, Sarah, Vanden Eynden, Elke, Craessaerts, Katleen, Thrupp, Nicky, Wolfs, Leen, Horré, Katrien, Fourne, Yannick, Ronisz, Alicja, Silajdžić, Edina, Penning, Amber, Tosoni, Giorgia, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Thal, Dietmar Rudolf, Zetterberg, Henrik, Thuret, Sandrine, Fiers, Mark, Frigerio, Carlo Sala, De Strooper, Bart, Salta, Evgenia·2021·Cell Stem Cell
DOI 10.1016/j.stem.2021.05.001
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Figure S2 Related to Figure 2. A, B. In situ hybridization using a scramble control probe combined with Nestin and Ki-67 (A) or Nestin and doublecortin (DCX) (B) immunolabeling in the dentate gyrus of 3month-old Nestin:GFP mice. Scale bar, 50 µm. C. Semi-quantitative real-time PCR of miR-212 levels in GFP + or GFP -populations sorted from the dentate gyrus of Nestin:GFP mice at 1.5, 3, 6, 9 and 12 months of age. N=6-8 mice per time point. D, E. Semi-quantitative real-time PCR of miR-212 levels in GFP + (D) or GFP -(E) populations sorted from the dentate gyrus of sedentary control or running Nestin:GFP mice at 3 months of age. N=5-6 mice per group. F, G. Semi-quantitative real-time PCR of miR-124 levels in
Figure S2 Related to Figure 2. A, B. In situ hybridization using a scramble control probe combined with Nestin and Ki-67 (A) or Nestin and doublecortin (DCX) (B) immunolabeling in the dentate gyrus of 3month-old Nestin:GFP mice. Scale bar, 50 µm. C. Semi-quantitative real-time PCR of miR-212 levels in GFP + or GFP -populations sorted from the dentate gyrus of Nestin:GFP mice at 1.5, 3, 6, 9 and 12 months of age. N=6-8 mice per time point. D, E. Semi-quantitative real-time PCR of miR-212 levels in GFP + (D) or GFP -(E) populations sorted from the dentate gyrus of sedentary control or running Nestin:GFP mice at 3 months of age. N=5-6 mice per group. F, G. Semi-quantitative real-time PCR of miR-124 levels inCC-BY-NC-ND · From the PDF
Figure S3 Related to Figure 3. A. Semi-quantitative real-time PCR of miR-132 levels in scramble- and Ant-132-injected 9-month-old C57Bl/6 mice prior to running. N=6 mice per group. B. Semi-quantitative real-time PCR of miR-132 levels in GFP + - and GFP --cells sorted from the dentate gyrus of Nestin:GFP
Figure S3 Related to Figure 3. A. Semi-quantitative real-time PCR of miR-132 levels in scramble- and Ant-132-injected 9-month-old C57Bl/6 mice prior to running. N=6 mice per group. B. Semi-quantitative real-time PCR of miR-132 levels in GFP + - and GFP --cells sorted from the dentate gyrus of Nestin:GFPCC-BY-NC-ND · From the PDF
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Figure S5 Related to Figures 5 and 8. A, B. Semi-quantitative real-time PCR of miR-132 levels in the dentate gyrus of control- or miR-132-injected 9-month-old APP/PS1 (A) and App NL-G-F (B) mice prior to running. N=4-10 mice per group. C. Semi-quantitative real-time PCR of miR-132 levels in the dentate gyrus of control- or miR-132-injected App NL-G-F 9-month-old female mice prior to running. N=4-5 mice per group. D. Quantification of BrdU + -cells in the dentate gyrus of control- or miR-132-injected, sedentary or running App NL-G-F female mice at 9 months of age. N=4-8 mice per group. E. Semiquantitative real-time PCR of miR-132 and miR-212 levels in the dentate gyrus of C57Bl/6 and App NL-GF mice that were exposed to behavioral testing upon miR-132 overexpression. F. Dcx immunolabeling in the dentate gyrus of saline or TMZ-, Ctr- or miR-132-injected App NL-G-F mice after passive avoidance test completion. G. Quantification of Dcx + -cells upon saline or TMZ injections in Ctr- or miR-132-
Figure S5 Related to Figures 5 and 8. A, B. Semi-quantitative real-time PCR of miR-132 levels in the dentate gyrus of control- or miR-132-injected 9-month-old APP/PS1 (A) and App NL-G-F (B) mice prior to running. N=4-10 mice per group. C. Semi-quantitative real-time PCR of miR-132 levels in the dentate gyrus of control- or miR-132-injected App NL-G-F 9-month-old female mice prior to running. N=4-5 mice per group. D. Quantification of BrdU + -cells in the dentate gyrus of control- or miR-132-injected, sedentary or running App NL-G-F female mice at 9 months of age. N=4-8 mice per group. E. Semiquantitative real-time PCR of miR-132 and miR-212 levels in the dentate gyrus of C57Bl/6 and App NL-GF mice that were exposed to behavioral testing upon miR-132 overexpression. F. Dcx immunolabeling in the dentate gyrus of saline or TMZ-, Ctr- or miR-132-injected App NL-G-F mice after passive avoidance test completion. G. Quantification of Dcx + -cells upon saline or TMZ injections in Ctr- or miR-132-CC-BY-NC-ND · From the PDF
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Authors
Walgrave, H., Balusu, S., Snoeck, S., Vanden Eynden, E., Craessaerts, K., Thrupp, N., Wolfs, L., Horré, K., Fourne, Y., Ronisz, A., Silajdžić, E., Penning, A., Tosoni, G., Callaerts-Vegh, Z., D’Hooge, R., Thal, D. R., Zetterberg, H., Thuret, S., Fiers, M., Frigerio, C. S., De Strooper, B., & Salta, E.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2021-10
Volume
28
Issue
10
Pages
1805-1821.e8
ISSN
1934-5909
DOI
10.1016/j.stem.2021.05.001
Cited by
175
References
29
Language
en
Licence
Funders
  • KU Leuven
  • Horizon 2020
  • Alzheimer's Association
  • Vlaamse regering
  • Medical Research Council (MR/N030087/1, MR/S00484X/1)
  • European Research Council (ERC-2010-AG_268675)
  • European External Action Service

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Walgrave, H., Balusu, S., Snoeck, S., Vanden Eynden, E., Craessaerts, K., Thrupp, N., Wolfs, L., Horré, K., Fourne, Y., Ronisz, A., Silajdžić, E., Penning, A., Tosoni, G., Callaerts-Vegh, Z., D’Hooge, R., Thal, D. R., Zetterberg, H., Thuret, S., Fiers, M., . . . Salta, E. (2021). Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease. Cell Stem Cell. https://doi.org/10.1016/j.stem.2021.05.001