Controllability Modulates the Anticipatory Response in the Human Ventromedial Prefrontal Cortex
Open accessAbstract
Research has consistently shown that control is critical to psychological functioning, with perceived lack of control considered to play a crucial role in the manifestation of symptoms in psychiatric disorders. In a model of behavioral control based on non-human animal work, Maier et al. (2006) posited that the presence of control activates areas of the ventromedial prefrontal cortex (vmPFC), which in turn inhibit the normative stress response in the dorsal raphe nucleus and amygdala. To test Maier's model in humans, we investigated the effects of control over potent aversive stimuli by presenting video clips of snakes to 21 snake phobics who were otherwise healthy with no comorbid psychopathologies. Based on prior research documenting that disrupted neural processing during the anticipation of adverse events can be influenced by different forms of cognitive processing such as perceptions of control, analyses focused on the anticipatory activity preceding the videos. We found that phobics exhibited greater vmPFC activity during the anticipation of snake videos when they had control over whether the videos were presented as compared to when they had no control over the presentation of the videos. In addition, observed functional connectivity between the vmPFC and the amygdala is consistent with previous work documenting vmPFC inhibition of the amygdala. Our results provide evidence to support the extension of Maier's model of behavioral control to include anticipatory function in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Kerr et al., vmPFC activity was selectively higher on controllable snake trials than other conditions; control did not increase vmPFC activity on neutral fish trials.
“Importantly, there was one condition that selectively excited ventromedial prefrontal cortex activity – snake controllable trials. Control did not increase ventromedial prefrontal cortex activity on neutral fish trials, even though the subjects pressed. Ventromedial prefrontal cortex activity was higher on controllable snake trials than in any of the other conditions.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Kerr et al. (2012)
The Results (fMRI activation results; page unavailable) report greater anticipatory vmPFC activation for controllable than uncontrollable snake trials, but no significant vmPFC difference between controllable and uncontrollable fish trials. They do not establish that vmPFC activity on controllable snake trials was higher than in every other individual condition; the reported snake-versus-fish vmPFC comparison collapses across controllability. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn Kerr et al., there was a negative relationship between vmPFC and amygdala activity on snake trials.
“Finally, there was a negative relationship between ventromedial prefrontal cortex and amygdala activity on snake trials.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Kerr et al. (2012)
The Results (fMRI context-dependent connectivity/gPPI results; page unavailable) report vmPFC–amygdala connectivity during anticipation of snake videos, including greater connectivity for controllable snake than controllable fish trials. They do not report a negative relationship between the regions’ activity on snake trials. The Discussion also cautions that PPI cannot conclusively establish the direction of their association. (LLM, conf=0.85)
Experimental — accuracy not yet measuredIn Kerr et al. (2012), perceived control over snake presentation reduced anticipatory anxiety on snake trials.
“As expected, perceived control over the snake presentation reduced anticipatory anxiety on snake trials.”
From Learned helplessness at fifty: Insights from neuroscience. (2016) · cites this paper as Kerr, McLaren, Mathy, and Nitschke (2012)
The Introduction (page unavailable) describes controllable and uncontrollable snake-video trials, and the Abstract reports greater anticipatory vmPFC activity when participants had control. The copy does not report that perceived control reduced anticipatory anxiety on snake trials; its reported finding is a difference in neural activity, not a measured reduction in anxiety. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Self-efficacy: The exercise of control
Bandura, A., Freeman, W. H., & Lightsey, R. (1999) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.13.2.158 · Cited by 46,835 · see citing works
Self-efficacy: Toward a unifying theory of behavioral change
Bandura, A. (1977) · Psychological Review · doi:10.1037/0033-295x.84.2.191 · Cited by 43,925 · see citing works
Self-efficacy: the exercise of control
(1997) · Choice Reviews Online · doi:10.5860/choice.35-1826 · Cited by 24,409 · see citing works
(1985) · Medical Entomology and Zoology · Cited by 19,180 · see citing works
Ordinary magic: Resilience processes in development.
Masten, A. S. (2001) · American Psychologist · doi:10.1037/0003-066x.56.3.227 · Cited by 8,497 · see citing works
Human agency in social cognitive theory.
Bandura, A. (1989) · American Psychologist · doi:10.1037/0003-066x.44.9.1175 · Cited by 8,263 · see citing works
Learned helplessness in humans: Critique and reformulation.
Abramson, L. Y., Seligman, M. E., & Teasdale, J. D. (1978) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.87.1.49 · Cited by 7,121 · see citing works
Helplessness: On Depression, Development, and Death
Seligman, M. E. P. (1975) · CERN Document Server (European Organization for Nuclear Research) · Cited by 6,181 · see citing works
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · see citing works
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Social Cognitive Theory in Cultural Context
Bandura, A. (2002) · Applied Psychology · doi:10.1111/1464-0597.00092 · Cited by 2,092 · see citing works
Failure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 3× · see citing works
“, 1975); (2) learned helplessness can be mitigated by prior escapable trials that induce perceived control (Seligman and Maier, 1967); and (3) learned helplessness can be reversed by showing that shocks are escapable (Seligman et al.”
BackgroundNeurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1× · see citing works
“Non-human animal research has consistently demonstrated this top-down inhibition of the amygdala by the vmPFC during fear extinction (Morgan et al., 1993; Milad and Quirk, 2002; Quirk et al., 2003; Rosenkranz et al., 2003; Delgado et al., 2008).”
BackgroundEffects of an expanding-spaced vs massed exposure schedule on fear reduction and return of fear
Rowe, M. K., & Craske, M. G. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(97)10016-x · Cited by 1,778 · see citing works
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753 · see citing works
Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works
McLaren, D. G., Ries, M. L., Xu, G., & Johnson, S. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.068 · Cited by 1,445 · see citing works
Self-citationThe development of anxiety: The role of control in the early environment.
Chorpita, B. F., & Barlow, D. H. (1998) · Psychological Bulletin · doi:10.1037/0033-2909.124.1.3 · Cited by 1,382 · see citing works
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.029 · Cited by 1,360 · see citing works
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Effects of inescapable shock upon subsequent escape and avoidance responding.
Overmier, J. B., & Seligman, M. E. P. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0024166 · Cited by 1,200 · see citing works
Amygdala–frontal connectivity during emotion regulation
Banks, S. J., Eddy, K. T., Angstadt, M., Nathan, P. J., & Phan, K. L. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm029 · Cited by 1,187 · cited 1× · see citing works
“Although the direction of the association between the vmPFC and amygdala cannot be conclusively determined on the basis of PPI alone (Friston et al., 1997; Banks et al., 2007), vmPFC inhibition of the amygdala is of considerable significance for translational neuroscience.”
BackgroundA Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
Van Essen, D. C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.058 · Cited by 1,151 · see citing works
Role of Affective Self-Regulatory Efficacy in Diverse Spheres of Psychosocial Functioning
Bandura, A., Caprara, G. V., Barbaranelli, C., Gerbino, M., & Pastorelli, C. (2003) · Child Development · doi:10.1111/1467-8624.00567 · Cited by 1,092 · see citing works
Urry, H. L., van Reekum, C. M., Johnstone, T., Kalin, N. H., Thurow, M. E., Schaefer, H. S., Jackson, C. A., Frye, C. J., Greischar, L. L., Alexander, A. L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3215-05.2006 · Cited by 1,056 · see citing works
Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2063-07.2007 · Cited by 1,051 · see citing works
Masten, A. S. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000198 · Cited by 993 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
Quirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927 · see citing works
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 1× · see citing works
“Non-human animal research has consistently demonstrated this top-down inhibition of the amygdala by the vmPFC during fear extinction (Morgan et al., 1993; Milad and Quirk, 2002; Quirk et al., 2003; Rosenkranz et al., 2003; Delgado et al., 2008).”
BackgroundGenerality of learned helplessness in man.
Hiroto, D. S., & Seligman, M. E. (1975) · Journal of Personality and Social Psychology · doi:10.1037/h0076270 · Cited by 896 · cited 1× · see citing works
“The extension of Seligman’s learned helplessness model to humans (Hiroto and Seligman, 1975) required refinement precisely because humans are a meaning-making species and attribute helplessness to a cause, whether “stable or unstable, global or specific, and internal or external” (Abramson et al.”
BackgroundGitelman, D. R., Penny, W. D., Ashburner, J., & Friston, K. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00058-2 · Cited by 799 · see citing works
Neural circuitry underlying the regulation of conditioned fear and its relation to extinction
Delgado, M. R., Nearing, K. I., LeDoux, J. E., & Phelps, E. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.029 · Cited by 716 · see citing works
Anxiety and Its Disorders: The Nature and Treatment of Anxiety and Panic
Noyes, R. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.8.1083 · Cited by 681 · see citing works
Factors and processes contributing to resilience: The resilience framework.
Kumpfer, K. L. (1999) · Cited by 483 · see citing works
Learned helplessness in the rat.
Seligman, M. E., & Beagley, G. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0076430 · Cited by 481 · see citing works
Vulnerability research and the issue of primary prevention.
Garmezy, N. (1971) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.1971.tb01111.x · Cited by 410 · see citing works
Functional neuroanatomy of aversion and its anticipation
Nitschke, J. B., Sarinopoulos, I., Mackiewicz, K. L., Schaefer, H. S., & Davidson, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.068 · Cited by 398 · see citing works
Self-citationCurtis, W. J., & Cicchetti, D. (2003) · Development and Psychopathology · doi:10.1017/s0954579403000373 · Cited by 383 · see citing works
Nitschke, J. B., Sarinopoulos, I., Oathes, D. J., Johnstone, T., Whalen, P. J., Davidson, R. J., & Kalin, N. H. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101682 · Cited by 375 · see citing works
Self-citationRosenkranz, J. A., Moore, H., & Grace, A. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11054.2003 · Cited by 344 · see citing works
Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders
Myers-Schulz, B., & Koenigs, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.88 · Cited by 333 · see citing works
Wiech, K., Kalisch, R., Weiskopf, N., Pleger, B., Stephan, K. E., & Dolan, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2568-06.2006 · Cited by 323 · see citing works
Role of the medial prefrontal cortex in coping and resilience
Maier, S. F., & Watkins, L. R. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.039 · Cited by 292 · see citing works
Alleviation of learned helplessness in the dog.
Seligman, M. E. P., Maier, S. F., & Geer, J. H. (1968) · Journal of Abnormal Psychology · doi:10.1037/h0025831 · Cited by 291 · see citing works
Learned helplessness in the rat: time course, immunization, and reversibility.
Seligman, M., Rosellini, R., & Kozak, M. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0076431 · Cited by 287 · see citing works
Waiting for spiders: Brain activation during anticipatory anxiety in spider phobics
Straube, T., Mentzel, H.-J., & Miltner, W. H. R. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.023 · Cited by 282 · see citing works
Attributional style and the generality of learned helplessness.
Alloy, L. B., Peterson, C., Abramson, L. Y., & Seligman, M. E. (1984) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.46.3.681 · Cited by 275 · see citing works
Staudinger, U. M., Marsiske, M., & Baltes, P. B. (1995) · Max Planck Digital Library · Cited by 257 · see citing works
Perceived Controllability Modulates the Neural Response to Pain
Salomons, T. V., Johnstone, T., Backonja, M.-M., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1315-04.2004 · Cited by 253 · see citing works
Amat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249 · see citing works
Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala
Sarinopoulos, I., Grupe, D. W., Mackiewicz, K. L., Herrington, J. D., Lor, M., Steege, E. E., & Nitschke, J. B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp155 · Cited by 241 · see citing works
Self-citationComprehensive soldier fitness: A vision for psychological resilience in the U.S. Army.
Casey, G. W. (2011) · American Psychologist · doi:10.1037/a0021930 · Cited by 236 · see citing works
Zimmerman, M. A., Ramírez-Valles, J., & Maton, K. I. (1999) · American Journal of Community Psychology · doi:10.1023/a:1022205008237 · Cited by 232 · see citing works
Behavioral control, the medial prefrontal cortex, and resilience
Maier, S. F., Amat, J., Baratta, M. V., Paul, E. D., & Watkins, L. R. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/smaier · Cited by 231 · see citing works
An Evaluation of the Use of Magnetic Field Maps to Undistort Echo-Planar Images
Cusack, R., Brett, M., & Osswald, K. (2002) · NeuroImage · doi:10.1006/nimg.2002.1281 · Cited by 219 · see citing works
Jankowski, M. P., & Sesack, S. R. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10976 · Cited by 186 · see citing works
Neural Mechanisms of Automatic and Direct Processing of Phobogenic Stimuli in Specific Phobia
Straube, T., Mentzel, H., & Miltner, W. H. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.013 · Cited by 184 · see citing works
Maier, S. F., Grahn, R. E., Kalman, B. A., Sutton, L. C., Wiertelak, E. P., & Watkins, L. R. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.2.377 · Cited by 177 · see citing works
Carlsson, K., Petersson, K. M., Lundqvist, D., Karlsson, A., Ingvar, M., & Öhman, A. (2004) · Emotion · doi:10.1037/1528-3542.4.4.340 · Cited by 173 · see citing works
Fear Is Fast in Phobic Individuals: Amygdala Activation in Response to Fear-Relevant Stimuli
Larson, C. L., Schaefer, H. S., Siegle, G. J., Jackson, C. A., Anderle, M. J., & Davidson, R. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.079 · Cited by 156 · see citing works
Anxiety and the Interruption of Behavior
Mandler, G., & Watson, D. (1966) · Elsevier eBooks · doi:10.1016/b978-1-4832-3131-0.50016-0 · Cited by 151 · see citing works
Mackiewicz, K. L., Sarinopoulos, I., Cleven, K. L., & Nitschke, J. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601648103 · Cited by 147 · see citing works
Self-citationHartley, C. A., Fischl, B., & Phelps, E. A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq253 · Cited by 143 · see citing works
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.404 · Cited by 136 · see citing works
Maier, S. F., Grahn, R. E., Kalman, B. A., et al. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.2.377 · Cited by 134 · see citing works
Efference and the conscious experience of perception.
Festinger, L., Ono, H., & Burnham, C. A. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024766 · Cited by 125 · see citing works
Emotion-Related Self-Regulation in Children
Eisenberg, N., & Sulik, M. J. (2011) · Teaching of Psychology · doi:10.1177/0098628311430172 · Cited by 118 · see citing works
Stress-Resilience, Illness, and Coping: A Person-Focused Investigation of Young Women Athletes
Yi, J. P., Smith, R. E., & VITALIANO, P. P. (2005) · Journal of Behavioral Medicine · doi:10.1007/s10865-005-4662-1 · Cited by 107 · see citing works
Christianson, J. P., Thompson, B. M., Watkins, L. R., & Maier, S. F. (2008) · Stress · doi:10.1080/10253890802510302 · Cited by 87 · see citing works
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Joy Hirsch, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.12.003 · Cited by 84 · see citing works
Maier, S. F., Busch, C. R., Maswood, S., Grahn, R. E., & al, E. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.4.759 · Cited by 73 · see citing works
In vivo Serotonin release and learned helplessness
Petty, F., Kramer, G. L., Wilson, L. B., & Jordan, S. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90074-4 · Cited by 71 · see citing works
Developmental Psychopathology and Wellness: Genetic and Environmental Influences
(2008) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318187e7d2 · Cited by 66 · see citing works
Expectancy changes in depression and schizophrenia.
Abramson, L. Y., Garber, J. E., Edwards, N. B., et al. (1978) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.87.1.102 · Cited by 65 · see citing works
Scopinho, A. A., Scopinho, M., Lisboa, S. F. D. S., Corrêa, F. M. D. A., Guimarães, F. S., & Joca, S. R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.018 · Cited by 59 · see citing works
Maier, S. F., Busch, C. R., Maswood, S., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.759 · Cited by 53 · see citing works
Imaging Genetics for Neuropsychiatric Disorders
Meyer‐Lindenberg, A., & Zink, C. F. (2007) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.02.005 · Cited by 21 · see citing works
McFarlin, D. R., Kerr, D. L., & Nitschke, J. B. (2012) · Brain Connectivity · doi:10.1089/brain.2012.0093 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Freud S. (1936). The Problem of Anxiety, trans. Huxley Bunker Alden New York: Psychoanalytic Quarterly Press
- Talairach J. Tournoux P. (1988). Co-Planar Sterotaxic Atlas of the Human Brain. New York: Thieme Medical Publishers
- Weiss J. M. (1991). “Stress-induced depression: critical neurochemical and electrophysiological changes,” in Neurobiology of Learning, Emotion, and Affect, ed. Madden I. (New York: Raven Press), 123– 154
Cited by
Sorted by citations
Learned helplessness at fifty: Insights from neuroscience.
Maier, S. F., & Seligman, M. E. P. (2016) · Psychological Review · doi:10.1037/rev0000033 · Cited by 919 · see citing works
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P. A., Paret, C., Kluetsch, R., Schmahl, C., Théberge, J., Neufeld, R. W. J., McKinnon, M. C., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23402 · Cited by 273 · see citing works
Neurobiology of fear and specific phobias
Garcia, R. (2017) · Learning & Memory · doi:10.1101/lm.044115.116 · Cited by 239 · see citing works
Silvers, J. A., Lumian, D. S., Gabard-Durnam, L., Gee, D. G., Goff, B., Fareri, D. S., Caldera, C., Flannery, J., Telzer, E. H., Humphreys, K. L., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0038-16.2016 · Cited by 140 · see citing works
Maier, S. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.003 · Cited by 143 · see citing works
Agency and the Calibration of Motivated Behavior
Moscarello, J. M., & Hartley, C. A. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.06.008 · Cited by 137 · see citing works
Resilience training that can change the brain.
Tabibnia, G., & Radecki, D. (2018) · Consulting psychology journal · doi:10.1037/cpb0000110 · Cited by 114 · see citing works
A Reward-Based Framework of Perceived Control
Ly, V., Wang, K. S., Bhanji, J. P., & Delgado, M. R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00065 · Cited by 112 · see citing works
An affective neuroscience model of boosting resilience in adults
Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 109 · see citing works
Seeding Stress Resilience through Inoculation
Ashokan, A., Sivasubramanian, M., & Mitra, R. (2016) · Neural Plasticity · doi:10.1155/2016/4928081 · Cited by 71 · see citing works
Rzepa, E., Fisk, J., & McCabe, C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116681416 · Cited by 68 · see citing works
Stress-sensitive inference of task controllability
Ligneul, R., Mainen, Z. F., Ly, V., & Cools, R. (2022) · Nature Human Behaviour · doi:10.1038/s41562-022-01306-w · Cited by 60 · see citing works
Controllability modulates the neural response to predictable but not unpredictable threat in humans
Wood, K. H., Wheelock, M. D., Shumen, J. R., Bowen, K. H., Hoef, L. V., & Knight, D. C. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.086 · Cited by 57 · see citing works
Controllability over stressor decreases responses in key threat-related brain areas
Limbachia, C., Morrow, K., Khibovska, A., Meyer, C., Padmala, S., & Pessoa, L. (2021) · Communications Biology · doi:10.1038/s42003-020-01537-5 · Cited by 57 · see citing works
Sex differences in resilience: Experiential factors and their mechanisms
Fallon, I. P., Tanner, M. K., Greenwood, B. N., & Baratta, M. V. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14639 · Cited by 56 · see citing works
Viviani, R. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00123 · Cited by 52 · see citing works
How perception of control shapes decision making
Wang, K. S., Yang, Y.-Y., & Delgado, M. R. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.04.003 · Cited by 46 · see citing works
Current research and emerging directions in emotion-cognition interactions
Dolcos, F., Wang, L., & Mather, M. (2014) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2014.00083 · Cited by 45 · see citing works
Neural signatures of arbitration between Pavlovian and instrumental action selection
Gershman, S. J., Guitart‐Masip, M., & Cavanagh, J. F. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008553 · Cited by 40 · see citing works
Shao, R., Lau, W. K., Leung, M.-K., & Lee, T. M. C. (2018) · Brain and Cognition · doi:10.1016/j.bandc.2018.05.001 · Cited by 35 · see citing works
Dean, Z., Horndasch, S., Giannopoulos, P., & McCabe, C. (2016) · Psychological Medicine · doi:10.1017/s003329171600088x · Cited by 34 · see citing works
Johnsen, B. H., Hansen, A. L., Murison, R. C. C., Eid, J., & Thayer, J. F. (2012) · PubMed · Cited by 25 · see citing works
Klahn, A. L., Klinkenberg, I. A. G., Lueken, U., Notzon, S., Arolt, V., Pantev, C., Zwanzger, P., & Junghoefer, M. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.02.013 · Cited by 21 · see citing works
Initial and sustained brain responses to threat anticipation in blood-injection-injury phobia
Brinkmann, L., Poller, H., Herrmann, M. J., Miltner, W. H. R., & Straube, T. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.12.015 · Cited by 19 · see citing works
Don't stress, it's under control: Neural correlates of stressor controllability in humans
Meine, L. E., Meier, J., Meyer, B., & Wessa, M. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118701 · Cited by 19 · see citing works
Dretsch, M. N., Wood, K. H., Daniel, T. A., Katz, J. S., Deshpande, G., Goodman, A. M., Wheelock, M. D., Wood, K. B., Denney, T. S., Traynham, S., et al. (2016) · The Open Neuroimaging Journal · doi:10.2174/1874440001610010111 · Cited by 18 · see citing works
A Computational Model of Hopelessness and Active-Escape Bias in Suicidality
Karvelis, P., & Diaconescu, A. O. (2022) · Computational Psychiatry · doi:10.5334/cpsy.80 · Cited by 21 · see citing works
Neural response to stress differs by sex in young adulthood
Cohen, J. E., Holsen, L. M., Ironside, M., Moser, A. D., Duda, J. M., Null, K. E., Perlo, S., Richards, C. E., Nascimento, N. F., Du, F., et al. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111646 · Cited by 17 · see citing works
Wu, J., Geng, X., Shao, R., Wong, N. M. L., Tao, J., Chen, L., Chan, C. C. H., & Lee, T. M. C. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.07.022 · Cited by 15 · see citing works
Anticipatory versus reactive spatial attentional bias to threat
Gladwin, T. E., Möbius, M., McLoughlin, S., & Tyndall, I. T. (2018) · British Journal of Psychology · doi:10.1111/bjop.12309 · Cited by 14 · see citing works
Späti, J., Chumbley, J., Doerig, N., Brakowski, J., Grosse Holtforth, M., Seifritz, E., & Spinelli, S. (2015) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.140225 · Cited by 11 · see citing works
Tafet, G. E., & Alonso, T. O. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1600165 · Cited by 16 · see citing works
Dissociable neural signatures of passive extinction and instrumental control over threatening events
Wanke, N., & Schwabe, L. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa074 · Cited by 10 · see citing works
Liu, Q., Wu, J., Zhang, L., Sun, X., Guan, Q., & Yao, Z. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.683914 · Cited by 10 · see citing works
Guitart‐Masip, M., Walsh, A. T., Dayan, P., & Olsson, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-45179-z · Cited by 11 · see citing works
Csifcsák, G., Bjørkøy, J., Kuyateh, S., Reithe, H., & Mittner, M. (2021) · eNeuro · doi:10.1523/eneuro.0041-21.2021 · Cited by 10 · see citing works
A Translational Paradigm to Study the Effects of Uncontrollable Stress in Humans
Meine, L. E., Schüler, K., Richter-Levin, G., Scholz, V., & Wessa, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176010 · Cited by 8 · see citing works
Incident experience predicts freezing-like responses in firefighters
Ly, V., Roijendijk, L., Hazebroek, H., Tonnaer, C., & Hagenaars, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186648 · Cited by 9 · see citing works
Wade-Bohleber, L., Haugg, A., Huber, S., Ernst, J., Grimm, S., Recher, D., Richter, A., Seifritz, E., Boeker, H., & Northoff, G. (2021) · Human Brain Mapping · doi:10.1002/hbm.25549 · Cited by 7 · see citing works
Dolcos, F., Denkova, E., Iordan, A. D., Shafer, A. T., Fernández, G., & Dolcos, S. M. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1483373 · Cited by 9 · see citing works
Stress-sensitive inference of task controllabilityPreprint
Ligneul, R., Mainen, Z. F., Ly, V., & Cools, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.19.390393 · Cited by 8 · see citing works
Internality and the internalisation of failure: Evidence from a novel task
Mancinelli, F., Roiser, J. P., & Dayan, P. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009134 · Cited by 6 · see citing works
Cremers, H. R., Keedy, S., & Coccaro, E. F. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111197 · Cited by 6 · see citing works
Anticipation and the Neural Response to Threat
Harnett, N. G., Wood, K. H., Wheelock, M. D., Knight, A. J., & Knight, D. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-45142-8_13 · Cited by 6 · see citing works
Dissocier les effets facilitants et les effets délétères de l’émotion sur la cognition
Dolcos, F., & Denkova, E. (2016) · Santé mentale au Québec · doi:10.7202/1036964ar · Cited by 5 · see citing works
Dissociating Enhancing and Impairing Effects of Emotion on Cognition
Dolcos, F., & Denkova, E. (2015) · Emerging Trends in the Social and Behavioral Sciences · doi:10.1002/9781118900772.etrds0079 · Cited by 5 · see citing works
Blythe, J. S., Mansueto, A. C., Duken, S. B., & Cremers, H. R. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111598 · Cited by 3 · see citing works
Brain encoding during perceived control as a prospective predictor of improvement in quality of life
Dan, R., Brown, A. R., Hutson, L. M., Belleau, E. L., Esfand, S. M., Ruberto, V., Johns, E., Null, K. E., Du, F., & Pizzagalli, D. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae075 · Cited by 3 · see citing works
Ghane, M., Sullivan‐Toole, H., Giacco, A. C. D., & Richey, J. A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100341 · Cited by 3 · see citing works
Singing for memory: neural and cognitive effects of a choral intervention in older adults
Napadow, M., Fischer, H., Sandgren, M., Magyar, M., Lénárd, Z., Harmat, L., & de Manzano, Ö. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1679873 · Cited by 2 · see citing works
Sedlinská, T., Bolte, L., Melsæter, E., Mittner, M., & Csifcsák, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1164208 · Cited by 2 · see citing works
Moral Reasoning: A Network Neuroscience Perspective
Anderson, E. D., & Barbey, A. K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108580298.025 · Cited by 1 · see citing works
Subjective Beliefs In, Out, and About Control: A Quantitative AnalysisPreprint
Mancinelli, F., Roiser, J. P., & Dayan, P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.27.115998 · Cited by 1 · see citing works
Neural Perspectives on Emotion-Cognition Interactions
Dolcos, F., & Dolcos, S. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00161-4 · Cited by 1 · see citing works
Arrhythmogenic Right Ventricular Cardiomyopathy: From Surviving to Thriving
Cory, J. S. (2015) · Scholarly Commons (University of Pennsylvania)
Cremers, H. R., Keedy, S., & Coccaro, E. F. (2017) · doi:10.31235/osf.io/7hu8w
Walsh, A. T., Dayan, P., Olsson, A., & Guitart‐Masip, M. (2022) · doi:10.31234/osf.io/jbuqt
Corbett, J. D., Silvers, J. A., & Wu, R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106754
- Authors
- Kerr, D. L., McLaren, D. G., Mathy, R. M., & Nitschke, J. B.
- Affiliations
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Central Oregon Community College (US)
- Corresponding author
- Kerr, Deborah L.
- Venue
- Frontiers in Psychology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 557-557
- ISSN
- 1664-1078 (ISSN-L)
- PMC
- PMC3582324
- OpenAlex
- W2135978520
- Cited by
- 61
- References
- 80
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 3 · 2012: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Waisman Center (HD03352)
- National Institutes of Health (5k02mh082130-05)
- National Institute on Aging (K23AG027171, P01AG036694)
- National Institute of Mental Health (K02‑MH082130, P30-HD03352, R01MH074847, K08MH063984, R01-MH74847, K08-MH63984)
- National Institute of Child Health and Human Development (P30HD03352, AG027171, HD03352)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003352)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perceived control, ventromedial prefrontal cortex, anticipatory processing, snake phobia, amygdala, dorsal raphe nucleus, aversive stimuli, functional connectivity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
