Cited by 215Pain Mechanisms and TreatmentsTactile and Sensory InteractionsIon Channels and Receptors

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Identification of a Spinal Circuit for Light Touch and Fine Motor Control

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Bourane, Steeve, Grossmann, Katja S., Britz, Olivier, Dalet, Antoine, Del Barrio, Marta Garcia, Stam, Floor J., Garcia-Campmany, Lidia, Koch, Stephanie, Goulding, Martyn·2015·Cell

DOI 10.1016/j.cell.2015.01.011PMC PMC4431637

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Abstract

Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory modalities including the sense of light touch. Here, we identify a population of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuous light touch sensation. These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs). Targeted removal of RORα INs in the dorsal spinal cord leads to a marked reduction in behavioral responsiveness to light touch without affecting responses to noxious and itch stimuli. RORα IN-deficient mice also display a selective deficit in corrective foot movements. This phenotype, together with our demonstration that the RORα INs are innervated by corticospinal and vestibulospinal projection neurons, argues that the RORα INs direct corrective reflex movements by integrating touch information with descending motor commands from the cortex and cerebellum.

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Authors: Bourane, S., Grossmann, K. S., Britz, O., Dalet, A., Del Barrio, M. G., Stam, F. J., Garcia-Campmany, L., Koch, S., & Goulding, M.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Goulding, Martyn
ORCID: Bourane, Steeve
Stam, Floor J.
Koch, Stephanie
Goulding, Martyn
Venue: Cell
Publisher: Elsevier BV
Published: 2015-01
Volume: 160
Issue: 3
Pages: 503-515
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.01.011
PMC: PMC4431637
OpenAlex: W2026910668
Cited by: 215
References: 82
Citations by year: 2026: 13 · 2025: 20 · 2024: 17 · 2023: 23 · 2022: 16 · 2021: 22 · 2020: 25 · 2019: 18 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 10
FWCI: 14.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 393 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS086372, NS080586, P30NS072031, NS072031, R01NS080586, NS086372)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: light touch, dorsal horn interneurons, low-threshold mechanoreceptors, dorsal spinal cord, descending motor control, nociception, pruritus, sensorimotor integration
MeSH terms: Animals, Interneurons, Motor Activity, Motor Neurons, Neural Pathways, Synapses, Touch, Mechanotransduction, Cellular, Mice, Nuclear Receptor Subfamily 1, Group F, Member 1, Spinal Cord Dorsal Horn

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Identification of a Spinal Circuit for Light Touch and Fine Motor Control

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