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The Nuclear Pore Complex as a Flexible and Dynamic Gate
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Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm. Stripping the megadalton complex down to its most essential organizational elements, one can divide the NPC into scaffold components, and the disordered elements attached to it that generate a selective barrier between compartments. These structural elements exhibit flexibility, which may hold a clue in understanding NPC assembly and function. Here we review the current status of NPC research with a focus on the functional implications of its structural and compositional heterogeneity.
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Sood, V., & Brickner, J. H. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.018 · Cited by 58
3D ultrastructure of the nuclear pore complex
Bilokapić, S., & Schwartz, T. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.12.011 · Cited by 55
Self-citationIntranuclear dynamics of the Nup107-160 complex
Morchoisne‐Bolhy, S., Geoffroy, M., Bouhlel, I. B., Alves, A., Audugé, N., Baudin, X., Bortle, K. V., Powers, M. A., & Doye, V. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-02-0060 · Cited by 55
Characterization of nuclear pore complex components in fission yeastSchizosaccharomyces pombe
Asakawa, H., Yang, H.-J., Yamamoto, T. G., Ohtsuki, C., Chikashige, Y., Sakata-Sogawa, K., Tokunaga, M., Iwamoto, M., Hiraoka, Y., & Haraguchi, T. (2014) · Nucleus · doi:10.4161/nucl.28487 · Cited by 53
Converging on the function of intrinsically disordered nucleoporins in the nuclear pore complex
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Handa, N., Kukimoto‐Niino, M., Akasaka, R., Kishishita, S., Murayama, K., Terada, T., Inoue, M., Kigawa, T., Kose, S., Imamoto, N., et al. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.07.089 · Cited by 50
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Integrative structure and functional anatomy of a nuclear pore complex
Kim, S. J., Fernandez-Martinez, J., Nudelman, I., Shi, Y., Zhang, W., Raveh, B., Herricks, T., Slaughter, B. D., Hogan, J. A., Upla, P., et al. (2018) · Nature · doi:10.1038/nature26003 · Cited by 490
Mechanisms and functions of nuclear envelope remodelling
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HIV-1 uncoats in the nucleus near sites of integration
Burdick, R. C., Li, C., Munshi, M., Rawson, J. M. O., Nagashima, K., Hu, W.-S., & Pathak, V. K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920631117 · Cited by 313
“It is unclear how an intact viral core with a width of ∼61 nm (5) can be imported through a NPC with an inner diameter of ∼39 nm (49).”
BackgroundPrinciples for Integrative Structural Biology Studies
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Structure and Assembly of the Nuclear Pore Complex
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Metadata
- Authors
- Knockenhauer, K. E., & Schwartz, T. U.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 164
- Issue
- 6
- Pages
- 1162-1171
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2293002570
- Cited by
- 406
- References
- 121
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
