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CRISPR system: Discovery, development and off-target detection

Chen, Shengmiao, Yao, Yufeng, Zhang, Yanchun, Fan, Gaofeng·2020·Cellular Signalling
DOI 10.1016/j.cellsig.2020.109577
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Abstract

As a revolutionary gene editing tool based on the adaptive immune defense mechanism of bacteria and archaea against exogenous DNA invasion, CRISPR/Cas system shows many remarkable characteristics over ZFNs and TALENs. However, off-target effect remains as one of the major imperfection of CRISPR/Cas system, hindering its further application in translational research. In this review, we highlight major breakthrough cross the development/application of this powerful toolkit, and summarize feasible methods for detecting potential off-target effects during genetic manipulation. We hope this review will assist scientists for accurate genomic editing in their future research.

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Metadata

Authors
Chen, S., Yao, Y., Zhang, Y., & Fan, G.
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2020-06
Volume
70
Pages
109577
ISSN
0898-6568
DOI
10.1016/j.cellsig.2020.109577
Cited by
60
References
20
Language
en
Licence
Funders
  • National Natural Science Foundation of China (31872831)
  • Ministry of Science and Technology of the People's Republic of China (2018YFC1004603)
  • ShanghaiTech University
  • Science and Technology Commission of Shanghai Municipality (19JC1413800)
  • Shanghai Shuguang Program (19SG55)

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