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Cited by 1,158

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Open access
Wang, Kai, Liao, Mingfang, Zhou, Nan, Bao, Li, Ma, Ke, Zheng, Zhongyong, Wang, Yujing, Liu, Chang, Wang, Wenzhao, Wang, Jun, Liu, Shuang-Jiang, Liu, Hongwei·2019·Cell Reports
DOI 10.1016/j.celrep.2018.12.028
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Abstract

We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice. Treatment with live P. distasonis (LPD) dramatically altered the bile acid profile with elevated lithocholic acid (LCA) and ursodeoxycholic acid (UDCA) and increased the level of succinate in the gut. In vitro cultivation of PD demonstrated its capacity to transform bile acids and production of succinate. Succinate supplementation in the diet decreased hyperglycemia in ob/ob mice via the activation of intestinal gluconeogenesis (IGN). Gavage with a mixture of LCA and UDCA reduced hyperlipidemia by activating the FXR pathway and repairing gut barrier integrity. Co-treatment with succinate and LCA/UDCA mirrored the benefits of LPD. The binding target of succinate was identified as fructose-1,6-bisphosphatase, the rate-limiting enzyme in IGN. The succinate and secondary bile acids produced by P. distasonis played key roles in the modulation of host metabolism.

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Metadata

Authors
Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., Liu, S.-J., & Liu, H.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2019-01
Volume
26
Issue
1
Pages
222-235.e5
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2018.12.028
OpenAlex
W2906742147
Cited by
1,158
References
67
FWCI
33.80
Type
journal article
Language
en
Open access
gold

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