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Cited by 30Muscle metabolism and nutritionClinical Nutrition and GastroenterologyNutrition and Health in Aging

Differential metabolic effects of casein and soy protein meals on skeletal muscle in healthy volunteers

Luiking, Yvette C., Engelen, Mariëlle P.K.J., Soeters, Peter B., Boirie, Yves, Deutz, Nicolaas E.P.·2011·Clinical Nutrition
DOI 10.1016/j.clnu.2010.06.012
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Abstract

Background & aims Dietary protein intake is known to affect whole body and interorgan protein turnover. We examined if moderate-nitrogen and carbohydrate casein and soy meals have a different effect on skeletal muscle protein and amino acid kinetics in healthy young subjects. Methods Muscle protein and amino acid kinetics were measured in the postabsorptive state and during 4-h enteral intake of isonitrogenous [0.21 g protein/(kg body weight. 4 h)] protein-based test meals, which contained either casein (CAPM; n = 12) or soy protein (SOPM; n = 10) in 2 separate groups. Stable isotope and muscle biopsy techniques were used to study metabolic effects. Results The net uptake of glutamate, serine, histidine, and lysine across the leg was larger during CAPM than during SOPM intake. Muscle concentrations of glutamate, serine, histidine, glutamine, isoleucine and BCAA changed differently after CAPM and SOPM (P < 0.05). Muscle net protein breakdown decreased significantly (P < 0.05) to zero during feeding of both CAPM and SOPM, but differences in their (net) breakdown rates were not significant. Muscle protein synthesis was not different between CAPM and SOPM. Conclusion Moderate-nitrogen casein and soy protein meals differently alter leg amino acid uptake without a significant difference in influencing acute muscle protein metabolism.

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Authors
Luiking, Y. C., Engelen, M. P. K. J., Soeters, P. B., Boirie, Y., & Deutz, N. E. P.
Affiliations
  • Maastricht University Medical Centre (NL)
  • University of Arkansas at Fayetteville (US)
Corresponding author
Deutz, Nicolaas E.P.
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2011-02
Volume
30
Issue
1
Pages
65-72
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2010.06.012
OpenAlex
W2064100779
Cited by
30
References
42
Citations by year
2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 8 · 2014: 3 · 2013: 2 · 2012: 5
FWCI
1.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Funders
  • Universiteit Maastricht
  • National Center for Research Resources (S10RR027047)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
casein, soy protein, skeletal muscle protein metabolism, muscle protein synthesis, muscle protein degradation, amino acid kinetics, lower limb muscles, glutamate, serine, histidine, lysine, branched-chain amino acids, glutamine, isoleucine, protein intake, nitrogen balance
MeSH terms
Amino Acids, Analysis of Variance, Caseins, Dietary Proteins, Female, Humans, Insulin, Male, Muscle Proteins, Linear Models, Single-Blind Method, Muscle, Skeletal, Soybean Proteins, Young Adult

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