EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
Abstract
Background & aims Older individuals are more likely to experience extended hospitalization and become protein malnourished during hospitalization. The concomitant compulsory inactivity results in functional decline. Increasing protein intake in hospitalized patients improves nitrogen balance, but effects on function are unknown. In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function. Methods Subjects were given a placebo (n=12, 68+/-5 (SD) yrs, 83+/-19 kg) or 15 g of EAA (n=10, 71+/-6, 72+/-8 kg) 3 times per day throughout 10d of bed rest. LBM, muscle protein synthesis, and muscle function were determined before and after bed rest. Due to an imbalance in randomized gender distribution between groups, gender and beginning functional and LBM measures were utilized for analyses by repeated measures analysis of covariance (RMANCOVA). Results Analyses revealed the potential for the preservation of functional outcomes with EAA supplementation. Conclusions Increasing protein intake above the RDA may preserve muscle function in the elderly during compulsory inactivity. EAA supplementation is potentially an efficient method of increasing protein intake without affecting satiety.
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Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury and chronic diseases such as COPD and congestive heart failure.
“Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury 153e160 and also for chronic diseases, such as COPD 161e165 and congestive heart failure (CHF).99,163,166”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [156]
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- Authors
- Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Kentucky (US)
- Corresponding author
- Ferrando, Arny A.
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 29
- Issue
- 1
- Pages
- 18-23
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2060119724
- Cited by
- 237
- References
- 35
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 18 · 2020: 23 · 2019: 19 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 22 · 2012: 20
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (PO1 AG023591, M01-RR-00073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- essential amino acid supplementation, protein intake, nitrogen balance, muscle function, muscle protein synthesis, muscle mass, bed rest, inactivity, older adults, protein malnutrition, functional decline
- MeSH terms
- Aged, Aging, Amino Acids, Essential, Analysis of Variance, Bed Rest, Body Composition, Female, Hospitalization, Humans, Male, Muscle Proteins, Nitrogen, Protein-Energy Malnutrition, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements
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