Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia

Phillips, Stuart M

doi:10.3945/an.115.008367

Cited by 144Nutrition and Health in AgingMuscle metabolism and nutritionMuscle Physiology and Disorders

Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia

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Phillips, Stuart M·2015·Advances in Nutrition

DOI 10.3945/an.115.008367PMC PMC4496741

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Abstract

Age-related sarcopenia, composed of myopenia (a decline in muscle mass) and dynapenia (a decline in muscle strength), can compromise physical function, increase risk of disability, and lower quality of life in older adults. There are no available pharmaceutical treatments for this condition, but evidence shows resistance training (RT) is a viable and relatively low-cost treatment with an exceptionally positive side effect profile. Further evidence suggests that RT-induced increases in muscle mass, strength, and function can be enhanced by certain foods, nutrients, or nutritional supplements. This brief review focuses on adjunctive nutritional strategies, which have a reasonable evidence base, to enhance RT-induced gains in outcomes relevant to sarcopenia and to reducing risk of functional declines.

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Protein supplementation in combination with resistance-type muscle strengthening exercise is an efficient intervention for lean mass and strength gain in elderly individuals.
“PS in combination with resistance-type MSE has been identified as an efficient intervention for LM and strength gain in elderly individuals [11,13,15,19,59,64].”
From The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials (2019) · cites this paper as [11]
The anti-inflammatory effects of n-3 PUFAs on skeletal muscle may be most beneficial to older individuals suffering from sarcopenia and may complement exercise and protein supplementation to combat sarcopenia.
“As such, the anti-inflammatory effects of n-3 PUFAs on skeletal muscle may be most beneficial to older individuals suffering from sarcopenia [32,50,51] and may complement other strategies, such as exercise and protein supplementation, to combat sarcopenia.”
From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [51]

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[38]38. Symons TB, Sheffield-Moore M, Wolfe RR, Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc 2009;109:1582 -6.

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Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging
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Nutrition, Resistance Training, and Sarcopenia
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Authors: Phillips, S. M.
Affiliations: McMaster University (CA)
Corresponding author: Phillips, Stuart M
ORCID: Phillips, Stuart M
Venue: Advances in Nutrition
Publisher: Elsevier BV
Published: 2015-07
Volume: 6
Issue: 4
Pages: 452-460
ISSN: 2156-5376 (ISSN-L)
2161-8313
DOI: 10.3945/an.115.008367
PMC: PMC4496741
OpenAlex: W2170406844
Cited by: 144
References: 102
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 29 · 2017: 17 · 2016: 14 · 2015: 1
FWCI: 2.50
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 6 d)
Locations: Advances in Nutrition (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (MOP- 123296)
Topics: Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: sarcopenia, resistance training, dietary supplements, myopenia, dynapenia, muscle mass, muscle strength, older adults, functional decline
MeSH terms: Aged, Aging, Creatine, Diet, Dietary Proteins, Female, Humans, Leucine, Male, Quality of Life, Valerates, Fatty Acids, Omega-3, Muscle, Skeletal, Dietary Supplements, Muscle Strength, Resistance Training, Sarcopenia

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Nutritional Supplements in Support of Resistance Exercise to Counter Age-Related Sarcopenia

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