The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
PGC1α expression is controlled in skeletal muscles by PPARβ, whose ablation results in fiber-type switching, obesity, and type 2 diabetes
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity
Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296
Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951
Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306981100 · Cited by 832
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657
Peroxisome proliferator‐activated receptor δ controls muscle development and oxydative capability
Luquet, S., Lopez‐Soriano, J., Holst, D., Fredenrich, A., Melki, J., Rassoulzadegan, M., & Grimaldi, P. A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0269fje · Cited by 509
Muscle fiber type is associated with obesity and weight loss
Tanner, C. J., Barakat, H. A., Dohm, G. L., Pories, W. J., MacDonald, K. G., Cunningham, P. R. G., Swanson, M. S., & Houmard, J. A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2001 · Cited by 493
Cited by
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222
PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD
Gross, B., Pawlak, M., Lefebvre, P., & Staels, B. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.135 · Cited by 778
Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., & Lee, C.-H. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.002 · Cited by 699
Lopaschuk, G. D., & Jaswal, J. S. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181e74a14 · Cited by 636
Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle
Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520
Exercise acts as a drug; the pharmacological benefits of exercise
Vina, J., Sanchis‐Gomar, F., Martinez‐Bello, V, & Gomez‐Cabrera, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01970.x · Cited by 443
PPARs: diverse regulators in energy metabolism and metabolic diseases
Wang, Y.-X. (2010) · Cell Research · doi:10.1038/cr.2010.13 · Cited by 366
Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells
Coll, T., Eyre, E., Rodríguez-Calvo, R., Palomer, X., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708700200 · Cited by 347
Muscle as a “Mediator” of Systemic Metabolism
Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333
Muscle fiber type diversification during exercise and regeneration
Qaisar, R., Bhaskaran, S., & Van Remmen, H. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.025 · Cited by 283
The Regulation of Fat Metabolism during Aerobic Exercise
Muscella, A., Stefàno, E., Lunetti, P., Capobianco, L., & Marsigliante, S. (2020) · Biomolecules · doi:10.3390/biom10121699 · Cited by 237
Peroxisome Proliferator Activator Receptor γ Coactivator-1 Expression Is Reduced in Obesity
Crunkhorn, S., Dearie, F., Mantzoros, C., Gami, H., da Silva, W. S., Espinoza, D., Faucette, R., Barry, K., Bianco, A. C., & Patti, M. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611214200 · Cited by 236
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Hong, F., Pan, S., Guo, Y., Xu, P., & Zhai, Y. (2019) · Molecules · doi:10.3390/molecules24142545 · Cited by 233
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes
Zorzano, A., Liesa, M., & Palacín, M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.02.004 · Cited by 209
Metabolic adaptation in obesity and type ii diabetes: myokines, adipokines and hepatokines
Oh, K.-J., Lee, D., Kim, W., Han, B., Lee, S., & Bae, K.-H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010008 · Cited by 210
PPARδ Promotes Running Endurance by Preserving Glucose
Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.006 · Cited by 198
Krämer, D. K., Al-Khalili, L., Guigas, B., Leng, Y., Garcia-Roves, P. M., & Krook, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702329200 · Cited by 180
PPARδ as a therapeutic target in metabolic disease
Reilly, S. M., & Lee, C.-H. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.040 · Cited by 164
Unravelling the mechanisms regulating muscle mitochondrial biogenesis
Hood, D. A., Tryon, L. D., Carter, H. N., Kim, Y., & Chen, C. C. W. (2016) · Biochemical Journal · doi:10.1042/bcj20160009 · Cited by 159
Physiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161
The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance
Pagel-Langenickel, I., Bao, J., Pang, L., & Sack, M. N. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0003 · Cited by 154
Excess of free fatty acids as a cause of metabolic dysfunction in skeletal muscle
TUMOVA, J., ANDEL, M., & TRNKA, J. (2016) · Physiological Research · doi:10.33549/physiolres.932993 · Cited by 143
“The ablation of PPARδ in skeletal muscle of mice led to obesity and diabetes (Schuler et al. 2006) and the activation of PPARδ with a synthetic agonist protected mice against high-fat diet-induced IR in skeletal muscle (Tanaka et al. 2003) and prevented FFA-induced inflammation and IR in muscle…”
BackgroundKleiner, S., Nguyen-Tran, V., Baré, O., Huang, X., Spiegelman, B., & Wu, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008797 · Cited by 143
Pagel-Langenickel, I., Bao, J., Joseph, J. J., Schwartz, D. R., Mantell, B. S., Xu, X., Raghavachari, N., & Sack, M. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800842200 · Cited by 124
PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle
Hondares, E., Pineda-Torra, I., Iglesias, R., Staels, B., Villarroya, F., & Giralt, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.092 · Cited by 120
Wang, P., Liu, J., Li, Y., Wu, S., Luo, J., Yang, H., Subbiah, R., Chatham, J., Zhelyabovska, O., & Yang, Q. (2010) · Circulation Research · doi:10.1161/circresaha.109.206185 · Cited by 110
PPARβ/δ: linking metabolism to regeneration
Magadum, A., & Engel, F. B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072013 · Cited by 110
Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity
Jeong, H.-J., Lee, H.-J., Vuong, T. A., Choi, K.-S., Choi, D., Koo, S.-H., Cho, S. C., Cho, H., & Kang, J.-S. (2016) · Diabetes · doi:10.2337/db15-1500 · Cited by 101
Barrientos, A., Gouget, K., Horn, D., Soto, I. C., & Fontanesi, F. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.05.003 · Cited by 99
Civitarese, A. E., MacLean, P. S., Carling, S., Kerr-Bayles, L., McMillan, R. P., Pierce, A., Becker, T. C., Moro, C., Finlayson, J., Lefort, N., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.004 · Cited by 95
Ren, Q., Chen, S., Chen, X., Niu, S., Yue, L., Pan, X., Li, Z., & Chen, X. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s381546 · Cited by 91
Interleukin-15 as a myokine: Mechanistic insight into its effect on skeletal muscle metabolism
Nadeau, L., & Aguer, C. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0022 · Cited by 83
Gene Polymorphisms and Fiber-Type Composition of Human Skeletal Muscle
Ahmetov, I. I., Vinogradova, O. L., & Williams, A. G. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.4.292 · Cited by 81
Phua, W. W. T., Wong, M. X. Y., Liao, Z., & Tan, N. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051425 · Cited by 72
Caloric restriction and exercise “mimetics”: ready for prime time
Handschin, C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.009 · Cited by 72
Tsika, R. W., Schramm, C., Simmer, G., Fitzsimons, D. P., Moss, R. L., & Ji, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807461200 · Cited by 65
Dietary Fat Influences the Expression of Contractile and Metabolic Genes in Rat Skeletal Muscle
Mizunoya, W., Iwamoto, Y., Shirouchi, B., Sato, M., Komiya, Y., Razin, F. R., Tatsumi, R., Sato, Y., Nakamura, M., & Ikeuchi, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080152 · Cited by 61
Percival, M. E., Martin, B. J., Gillen, J. B., Skelly, L. E., MacInnis, M. J., Green, A. E., Tarnopolsky, M. A., & Gibala, M. J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00048.2015 · Cited by 50
Nuclear Receptors in Nonalcoholic Fatty Liver Disease
López-Velázquez, J. A., Carrillo-Córdova, L. D., Chávez-Tapia, N. C., Uribe, M., & Méndez-Sánchez, N. (2012) · Journal of Lipids · doi:10.1155/2012/139875 · Cited by 48
Mitochondrial Inhibitor as a New Class of Insulin Sensitizer
Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47
Kawabata, F., Mizushige, T., Uozumi, K., Hayamizu, K., Han, L., Tsuji, T., & Kishida, T. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.951025 · Cited by 40
Quinn, L. S., Anderson, B. G., Conner, J. D., Wolden-Hanson, T., & Marcell, T. J. (2014) · Endocrinology · doi:10.1210/en.2013-1645 · Cited by 40
da Silva Aragão, R., Guzmán-Quevedo, O., Pérez-García, G., Manhães-de-Castro, R., & Bolaños-Jiménez, F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000865 · Cited by 35
Howard, E. E., & Margolis, L. M. (2020) · Nutrients · doi:10.3390/nu12092496 · Cited by 26
Metadata
- Authors
- Schuler, M., Ali, F., Chambon, C., Duteil, D., Bornert, J.-M., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., & Metzger, D.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 4
- Issue
- 5
- Pages
- 407-414
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1965621923
- Cited by
- 367
- References
- 8
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.