Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

Yoon, J. Cliff; Chickering, Troy W.; Rosen, Evan D.; Dussault, Barry; Qin, Yubin; Soukas, Alexander; Friedman, Jeffrey M.; Holmes, William E.; Spiegelman, Bruce M.

doi:10.1128/mcb.20.14.5343-5349.2000

Cited by 356

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

Yoon, J. Cliff, Chickering, Troy W., Rosen, Evan D., Dussault, Barry, Qin, Yubin, Soukas, Alexander, Friedman, Jeffrey M., Holmes, William E., Spiegelman, Bruce M.·2000·Molecular and Cellular Biology

DOI 10.1128/mcb.20.14.5343-5349.2000

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Fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues.
“fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [47]
Angptl4 is expressed in several tissues including liver, heart, intestine, and skeletal muscle.
“Although Angptl4 is most highly expressed in adipose, it is also expressed in several other tissues including liver, heart, intestine, and skeletal muscle (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [47]
ANGPTL4 was discovered as a secreted PPAR target gene expressed highly in adipose tissue.
“In 2000, two groups described the discovery of a secreted PPAR target gene expressed highly in adipose tissue (46, 47).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [47]

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Self-citation
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

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Research works printed but not linked: 31

Ausubel F., 1991, Current protocols in molecular biology.
10.1016/S1097-2765(00)80209-9 · DOI
10.1038/47254 · DOI · Paper page
10.1074/jbc.274.24.17042 · DOI
10.1128/MCB.17.7.4007 · DOI
10.1101/gad.3.9.1323 · DOI
10.1016/0092-8674(83)90037-5 · DOI
10.1016/S0092-8674(00)81812-7 · DOI · Paper page
10.1016/0092-8674(95)90193-0 · DOI
10.1126/science.7678183 · DOI · Paper page
10.1073/pnas.92.21.9856 · DOI
10.1038/34184 · DOI · Paper page
10.1016/S1097-2765(00)80210-5 · DOI
Lehmann J. M., 1995, J. Biol. Chem., 270, 12953, 10.1074/jbc.270.22.12953 · DOI
10.1016/S0092-8674(00)81654-2 · DOI
10.1126/science.277.5322.55 · DOI · Paper page
10.1016/S1097-2765(00)80047-7 · DOI
10.1074/jbc.274.42.30196 · DOI
10.1038/34178 · DOI · Paper page
Rosen E. D., Mol. Cell, 4, 611, 10.1016/S1097-2765(00)80211-7 · DOI
10.1038/2030 · DOI
10.1002/j.1460-2075.1996.tb00918.x · DOI · Paper page
10.1074/jbc.271.10.5301 · DOI
10.2337/diabetes.47.4.507 · DOI
10.1016/S0092-8674(00)81813-9 · DOI
10.1016/0092-8674(95)90151-5 · DOI · Paper page
10.1016/0092-8674(94)90006-X · DOI
Tontonoz P., 1994, Mol. Cell. Biol., 15, 351, 10.1128/MCB.15.1.351 · DOI
Wasserman F., Handbook of physiology, 5, 87
10.1021/jm950395a · DOI
10.1074/jbc.274.13.9116 · DOI

Sorted by citations

Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
Yang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., & Wahli, W. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.12.002 · Cited by 786
Mechanisms of nutritional and hormonal regulation of lipogenesis
Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700
Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance
Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.56 · Cited by 631
Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism
Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Hato, T., Tabata, M., & Oike, Y. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2007.10.003 · Cited by 351
SIRT6 protects against pathological damage caused by diet‐induced obesity
Kanfi, Y., Peshti, V., Gil, R., Naiman, S., Nahum, L., Levin, E., Kronfeld‐Schor, N., & Cohen, H. Y. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00544.x · Cited by 311
The Intestinal Microbiota in Metabolic Disease
Woting, A., & Blaut, M. (2016) · Nutrients · doi:10.3390/nu8040202 · Cited by 284
The adipocyte as an active participant in energy balance and metabolism
Badman, M. K., & Flier, J. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.058 · Cited by 256
Lipoprotein lipase and its regulators: an unfolding story
Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225
Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., Schick, F., Machicao, F., Stefan, N., Fritsche, A., & Häring, H.-U. (2009) · Diabetes · doi:10.2337/db07-1438 · Cited by 183
Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
Oike, Y., Yasunaga, K., & Suda, T. (2004) · International Journal of Hematology · doi:10.1532/ijh97.04034 · Cited by 160
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2021 · Cited by 154
Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor‐2‐mediated signaling
Dobrosi, N., Tóth, B. I., Nagy, G., Dózsa, A., Géczy, T., Nagy, L., Zouboulis, C. C., Paus, R., Kovács, L., & Bíró, T. (2008) · The FASEB Journal · doi:10.1096/fj.07-104877 · Cited by 142
Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes
Gray, N. E., Lam, L. N., Yang, K., Zhou, A. Y., Koliwad, S., & Wang, J.-C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294124 · Cited by 116
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
Cushing, E. M., Chi, X., Sylvers, K. L., Shetty, S. K., Potthoff, M. J., & Davies, B. S. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.007 · Cited by 88
Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice
Jacouton, E., Mach, N., Cadiou, J., Lapaque, N., Clément, K., Doré, J., van Hylckama Vlieg, J. E. T., Smokvina, T., & Blottière, H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138880 · Cited by 32
“Fiaf gene is considered as a target gene of peroxisome proliferator-activated receptors (PPARs) but several others regulators including glucocorticoids, and recently biliary acids have been described as Fiafmediators [14–16].”
Angiopoietin-like protein 4: a therapeutic target for triglycerides and coronary disease?
Olshan, D. S., & Rader, D. J. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.01.012 · Cited by 30
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation
Hu, H., Luo, S., Lai, P., Lai, M., Mao, L., Zhang, S., Jiang, Y., Wen, J., Zhou, W., Liu, X., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2310685120 · Cited by 18

Authors: Yoon, J. C., Chickering, T. W., Rosen, E. D., Dussault, B., Qin, Y., Soukas, A., Friedman, J. M., Holmes, W. E., & Spiegelman, B. M.
Affiliations: Dana-Farber Cancer Institute
Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2000-07-01
Volume: 20
Issue: 14
Pages: 5343-5349
ISSN: 1098-5549
DOI: 10.1128/mcb.20.14.5343-5349.2000
Cited by: 356
References: 2
Language: en
Licence: journals.asm.org/non-commercial-tdm-license (tdm)

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Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

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