Cellular signaling in the aging immune system

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373

Molecular mechanisms of T cell co-stimulation and co-inhibition

Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114

T Cell Activation

Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144

Mitogen-activated protein kinases in innate immunity

Arthur, J. S. C., & Ley, S. C. (2013) · Nature reviews. Immunology · doi:10.1038/nri3495 · Cited by 1,898

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793

Aging, frailty and age-related diseases

Fülöp, T., Larbi, A., Witkowski, J. M., McElhaney, J. E., Loeb, M. B., Mitnitski, A., & Pawelec, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9287-2 · Cited by 687

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.010 · Cited by 674

Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567

The kinetic-segregation model: TCR triggering and beyond

Davis, S. J., & van der Merwe, P. A. (2006) · Nature Immunology · doi:10.1038/ni1369 · Cited by 562

Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?

Weng, N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.001 · Cited by 476

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465

T cell receptor signalling networks: branched, diversified and bounded

Brownlie, R. J., & Zamoyska, R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3403 · Cited by 453

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

Wen, H., Miao, E. A., & Ting, J. P. ‐. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.037 · Cited by 415

SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels

Lorenz, U. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00760.x · Cited by 390

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349

Human T Cell Aging and the Impact of Persistent Viral Infections

Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347

Signal transduction and functional changes in neutrophils with aging

Fülöp, T., Larbi, A., Douziech, N., Fortin, C. F., Guérard, K., Lesur, O., Khalil, A., & Dupuis, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00110.x · Cited by 331

Beyond pattern recognition: five immune checkpoints for scaling the microbial threat

Blander, J. M., & Sander, L. E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3167 · Cited by 300

Regulation of protein tyrosine phosphatases by reversible oxidation

Östman, A., Frijhoff, J., Sandin, Å., & Böhmer, F. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr104 · Cited by 293

Tailoring T-cell receptor signals by proximal negative feedback mechanisms

Acuto, O., Bartolo, V. D., & Michel, F. (2008) · Nature reviews. Immunology · doi:10.1038/nri2397 · Cited by 245

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

Rhee, I., & Veillette, A. (2012) · Nature Immunology · doi:10.1038/ni.2246 · Cited by 240

Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells

Di Mitri, D., Azevedo, R. I., Henson, S. M., Libri, V., Riddell, N. E., Macaulay, R., Kipling, D., Soares, M. V. D., Battistini, L., & Akbar, A. N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100978 · Cited by 231

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Wiede, F., Shields, B. J., Chew, S., Kyparissoudis, K., van Vliet, C., Galić, S., Tremblay, M. L., Russell, S. M., Godfrey, D. I., & Tiganis, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59492 · Cited by 229

Pattern recognition receptor function in neutrophils

Thomas, C. J., & Schroder, K. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.008 · Cited by 220

Dysregulation of human Toll-like receptor function in aging

Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.007 · Cited by 215

Properties of end-stage human T cells defined by CD45RA re-expression

Henson, S. M., Riddell, N. E., & Akbar, A. N. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.001 · Cited by 180

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

Kwon, J., Shatynski, K. E., Chen, H., Morand, S. C., Deken, X. D., Miot, F., Leto, T. L., & Williams, M. S. (2010) · Science Signaling · doi:10.1126/scisignal.2000976 · Cited by 143

Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, C., Sjöblom, T., Groen, A. J., Kappert, K., Engström, U., Hellman, U., Heldin, C., den Hertog, J., & Östman, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304403101 · Cited by 139

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.003 · Cited by 134

Inhibition of Protein-tyrosine Phosphatases by Mild Oxidative Stresses Is Dependent on S-Nitrosylation

Barrett, D. M., Black, S. M., Todor, H., Schmidt‐Ullrich, R., Dawson, K. S., & Mikkelsen, R. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411523200 · Cited by 132

The role of the T cell in age-related inflammation

Macaulay, R., Akbar, A. N., & Henson, S. M. (2012) · AGE · doi:10.1007/s11357-012-9381-2 · Cited by 130

Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes

Larbi, A., Douziech, N., Dupuis, G., Khalil, A., Pelletier, H., Guérard, K., & Fülöp, T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703319 · Cited by 126

Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging

Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C., & Fülöp, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.016 · Cited by 126

Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells

Yasuda, K., Nagafuku, M., Shima, T., Okada, M., Yagi, T., Yamada, T., Minaki, Y., Kato, A., Tani‐ichi, S., Hamaoka, T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2813 · Cited by 126

The immunological synapse: a cause or consequence of T-cell receptor triggering?

Alarcón, B., Mestre, D., & Martínez, N. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03458.x · Cited by 120

Immunosenescence in vertebrates and invertebrates

Müller, L., Fülöp, T., & Pawelec, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-12 · Cited by 117

Involvement of SHP-1 Tyrosine Phosphatase in TCR-Mediated Signaling Pathways in Lipid Rafts

Kosugi, A., Sakakura, J., Yasuda, K., Ogata, M., & Hamaoka, T. (2001) · Immunity · doi:10.1016/s1074-7613(01)00146-7 · Cited by 113

Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions

Fortin, C. F., Larbi, A., Lesur, O., Douziech, N., & Fülöp, T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0805481 · Cited by 112

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27− T cells: the potential involvement of interleukin-7 in this process: IL-7 induces re-expression of CD45RA in CD4+ T cells

Libri, V., Azevedo, R. I., Jackson, S. E., Di Mitri, D., Lachmann, R., Fuhrmann, S., Vukmanovic-Stejic, M., Yong, K., Battistini, L., Kern, F., et al. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03386.x · Cited by 111

Impact of age on T cell signaling: A general defect or specific alterations?

Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J.-Y., & Fulop, T. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.008 · Cited by 108

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Stanford, S. M., Rapini, N., & Bottini, N. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03591.x · Cited by 105

Oxidative stress modulation and T cell activation

Larbi, A., Kempf, J., & Pawelec, G. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.004 · Cited by 102

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

Yu, M., Li, G., Lee, W.-W., Yuan, M., Cui, D., Weyand, C. M., & Goronzy, J. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109797109 · Cited by 102

Neutrophil Extracellular Traps as Innate Immune Reaction against the Emerging Apicomplexan Parasite Besnoitia besnoiti

MuĂąoz-Caro, T., Hermosilla, C. R., Silva, L. M. R., Cortes, H. C. E., & Taubert, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091415 · Cited by 100

Aging and Neutrophils: There Is Still Much To Do

Fortin, C. F., McDonald, P. P., Lesur, O., & Fülöp, T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0750 · Cited by 97

Molecular Mechanisms Involved in the Aging of the T-cell Immune Response

Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 86

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

Schoenborn, J. R., Tan, Y. X., Zhang, C., Shokat, K. M., & Weiss, A. (2011) · Science Signaling · doi:10.1126/scisignal.2001893 · Cited by 85

The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging

Larbi, A., Douziech, N., Fortin, C. F., Linteau, A., Dupuis, G., & Fülöp, T. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-6 · Cited by 79

Plasma membrane microdomains in aging and disease

Ohno‐Iwashita, Y., Shimada, Y., Hayashi, M., & Inomata, M. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00600.x · Cited by 72

Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes

Lenton, K. J., Therriault, H., Cantin, A. M., Fülöp, T., Payette, H., & Wagner, J. R. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1194 · Cited by 67

SHP-1 in T Cells Limits the Production of CD8 Effector Cells without Impacting the Formation of Long-Lived Central Memory Cells

Fowler, C., Pao, L. I., Blattman, J. N., & Greenberg, P. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001362 · Cited by 59

Free Radicals and Antioxidants: How to Reestablish Redox Homeostasis in Chronic Diseases?

Bocci, V. A., & Valacchi, G. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320270005 · Cited by 53

Low‐Grade Inflammation with Aging Has Consequences for T‐Lymphocyte Signaling

Larbi, A., Dupuis, G., Douziech, N., Khalil, A., & Fülöp, T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.016 · Cited by 50

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Coussens, N. P., Hayashi, R., Brown, P. H., Balagopalan, L., Balbo, A., Akpan, I. O., Houtman, J. C. D., Barr, V. A., Schuck, P., Appella, E., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00410-13 · Cited by 49

The role of membrane rafts in Lck transport, regulation and signalling in T-cells

Ventimiglia, L. N., & Alonso, M. A. (2013) · Biochemical Journal · doi:10.1042/bj20130468 · Cited by 47

Control of Immune Responses by Trafficking Cell Surface Proteins, Vesicles and Lipid Rafts to and from the Immunological Synapse

Taner, S. B., Önfelt, B., Pirinen, N. J., McCann, F. E., Magee, A. I., & Davis, D. M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00214.x · Cited by 44

Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

Le Page, A., Fortin, C., Garneau, H., Allard, N., Tsvetkova, K., Tan, C. T. Y., Larbi, A., Dupuis, G., & Fülöp, T. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-2 · Cited by 44

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

Henson, S. M., Macaulay, R., Franzese, O., & Akbar, A. N. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03550.x · Cited by 42

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Griffiths, H. R., Dunston, C. R., Bennett, S. J., Grant, M. M., Phillips, D. C., & Kitas, G. D. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391273 · Cited by 42

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells

Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42

Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor

Chapman, N. M., Connolly, S. F., Reinl, E. L., & Houtman, J. C. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301587 · Cited by 39

Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes

Füöp, T., Fóris, G., & Leovey, A. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90048-4 · Cited by 38

Lipid rafts in lymphocyte activation

Pizzo, P., & Viola, A. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.02.017 · Cited by 37

APC, T Cells, and the Immune Synapse

Reichardt, P., Dornbach, B., & Gunzer, M. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-03858-7_12 · Cited by 35

Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation

Choi, H. K., Kim, T. H., Jhon, G., & Lee, S. Y. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.017 · Cited by 34

Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation

Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., & Pawelec, G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.025 · Cited by 34

Aging, immunosenescence and membrane rafts: the lipid connection

Fülöp, T., Page, A. Y. L., Garneau, H., Azimi, N., Baëhl, S., Dupuis, G., Pawelec, G., & Larbi, A. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-6 · Cited by 34

Vitamin E, signalosomes and gene expression in T cells

Molano, A., & Meydani, S. N. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.11.002 · Cited by 30

The Immune System in the Elderly: A Fair Fight Against Diseases?

Larbi, A., Rymkiewicz, P. D., Vasudev, A., Low, I., Shadan, N. B., Mustafah, S., Ayyadhury, S., & Fülöp, T. (2013) · Aging Health · doi:10.2217/ahe.12.78 · Cited by 29

Do Membrane Rafts Contribute to Human Immunosenescence?

Tomoiu, A., Larbi, A., Fortin, C. F., Dupuis, G., & Fülöp, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.008 · Cited by 24

Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress

Khanfer, R., Carroll, D., Lord, J. M., & Phillips, A. C. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.09.013 · Cited by 20

Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function

Perkey, E., Fingar, D. C., Miller, R. A., & Garcia, G. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300750 · Cited by 20

Regulating naïve and memory CD8 T cell homeostasis – a role for protein tyrosine phosphatases

Pike, K. A., & Tremblay, M. L. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08587.x · Cited by 19

Aging of Cell Communication: Loss of Receptor Function

Robert, L., & Fülöp, T. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358903 · Cited by 15

A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts

Ballek, O., Broučková, A., Manning, J. E., & Filipp, D. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.01.001 · Cited by 12

Aging

Robert, L. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/isbn.978-3-318-02653-5 · Cited by 10

Age-related changes in lck–Vav signaling pathways in mouse CD4 T cells

Garcia, G. G., & Miller, R. A. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.06.001 · Cited by 9

Attention: a key to collaboration between health providers and older adult patients

Morrow, D. G. (2013) · Aging Health · doi:10.2217/ahe.12.82 · Cited by 8

There is still much to do.

Shribman, S. (2010) · PubMed · Cited by 4

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364

Immunology of aging: the birth of inflammaging

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439

Aging and the immune system: An overview

Akha, A. A. S. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.08.005 · Cited by 403

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362

SIGNAL TRANSDUCTION CHANGES IN IMMUNE CELLS WITH AGING

Fülöp, T., Page, A. Y. L., Fortin, C. F., Witkowski, J. M., Dupuis, G., & Larbi, A. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.4560

Intracellular signalling pathways: targets to reverse immunosenescence

Fülöp, T., Witkowski, J. M., Page, A. Y. L., Fortin, C. F., Pawelec, G., & Larbi, A. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12836 · Cited by 54

Immunosenescence: signaling pathways, diseases and therapeutic targets

Fu, Y., Wang, B., Alu, A., Hong, W., Hong, L., He, X., Shi, H., Cheng, P., & Yang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02371-z · Cited by 168

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

Cisneros, B., García‐Aguirre, I., Unzueta, J., Arrieta‐Cruz, I., González-Morales, O., Domínguez-Larrieta, J. M., Tamez-González, A., Leyva‐Gómez, G., & Magaña, J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1059173 · Cited by 97

Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases

Upadhyay, P., Suhail, A., Khanal, P., & Kumar, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637191 · Cited by 24