Pooled patient-level meta-analysis of children and adults completing a computer-based anxiety intervention targeting attentional bias
Open accessAbstract
Computer-based approaches, such as Attention Bias Modification (ABM), could help improve access to care for anxiety. Study-level meta-analyses of ABM have produced conflicting findings and leave critical questions unresolved regarding ABM's mechanisms of action and clinical potential. We pooled patient-level datasets from randomized controlled trials of children and adults with high-anxiety. Attentional bias (AB) towards threat, the target mechanism of ABM, was tested as an outcome and a mechanistic mediator and moderator of anxiety reduction. Diagnostic remission and Liebowitz Social Anxiety Scale (LSAS) were clinical outcomes available in enough studies to enable pooling. Per-patient data were obtained on at least one outcome from 13/16 eligible studies [86% of eligible participants; n=778]. Significant main effects of ABM on diagnostic remission (ABM-22.6%, control-10.8%; OR=2.57; p=0.006) and AB (β* (95%CI)=-0.63 (-0.83, -0.42); p<0.00005) were observed. There was no main effect of ABM on LSAS. However, moderator analyses suggested ABM was effective for patients who were younger (≤37y), trained in the lab, and/or assessed by clinicians. Under the same conditions where ABM was effective, mechanistic links between AB and anxiety reduction were supported. Under these specific circumstances, ABM reduces anxiety and acts through its target mechanism, supporting ABM's theoretical basis while simultaneously suggesting clinical indications and refinements to improve its currently limited clinical potential.
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ABM threat-avoidance training is less effective when delivered at home than in laboratory or clinic settings, possibly because greater distractions at home impair learning.
“ABM threatavoidance training is less effective when delivered at home than in laboratory/clinic settings, possibly because greater distractions at home impair learning [8,13].”
From Anxiety and Threat-Related Attention: Cognitive-Motivational Framework and Treatment (2018) · cites this paper as [13]
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Self-citation
- Authors
- Price, R. B., Wallace, M., Kuckertz, J. M., Amir, N., Graur, S., Cummings, L., Popa, P., Carlbring, P., & Bar-Haim, Y.
- Affiliations
- University of Pittsburgh (US)
- San Diego State University (US)
- Stockholm University (SE)
- Corresponding author
- Price, Rebecca B.
- ORCID
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 50
- Pages
- 37-49
- ISSN
- 0272-7358 (ISSN-L)
- PMC
- PMC5118070
- OpenAlex
- W2521619673
- Cited by
- 144
- References
- 65
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 14 · 2020: 16 · 2019: 26 · 2018: 30 · 2017: 11 · 2016: 1 · 2015: 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01MH096944, K23MH100259)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- attentional bias modification, attentional bias, anxiety, computer-based intervention, social anxiety, Liebowitz Social Anxiety Scale, mechanism of action, treatment moderators, children and adults, high anxiety
- MeSH terms
- Attentional Bias, Adult, Anxiety, Behavior Therapy, Child, Humans, Therapy, Computer-Assisted, Treatment Outcome
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