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MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts
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“In this network, besides miR-128-3p, miR-9 and miR-124-3p target and repress the expression of USP14 (Ubiquitin specific peptidase 14) whose product interacts with and stabilizes EZH2, thereby allowing the repression of EZH2 and the consequent destabilization of REST.160”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [160]
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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Ernst, T., Chase, A. J., Score, J., Hidalgo-Curtis, C. E., Bryant, C., Jones, A. V., Waghorn, K., Zoi, K., Ross, F. M., Reiter, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.621 · Cited by 1,139
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Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
Victor, M. B., Richner, M., Hermanstyne, T. O., Ransdell, J. L., Sobieski, C., Deng, P.-Y., Klyachko, V. A., Nerbonne, J. M., & Yoo, A. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.016 · Cited by 295
Self-citationPolycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
von Schimmelmann, M., Feinberg, P. A., Sullivan, J. M., Ku, S. M., Badimon, A., Duff, M. K., Wang, Z., Lachmann, A., Dewell, S., Ma'ayan, A., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4360 · Cited by 225
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Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. (2016) · eLife · doi:10.7554/elife.18648 · Cited by 213
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REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease
Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.023 · Cited by 216
Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01185-4 · Cited by 100
Self-citationDedifferentiation and neuronal repression define familial Alzheimer’s disease
Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. (2020) · Science Advances · doi:10.1126/sciadv.aba5933 · Cited by 69
Canalizing cell fate by transcriptional repression
Lim, B., Domsch, K., Mall, M., & Lohmann, I. (2024) · Molecular Systems Biology · doi:10.1038/s44320-024-00014-z · Cited by 19
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
Metadata
- Authors
- Lee, S. W., Oh, Y. M., Lu, Y.-L., Kim, W. K., & Yoo, A. S.
- ORCID
- Yoo, Andrew S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 46
- Issue
- 1
- Pages
- 73-84.e7
- ISSN
- 1534-5807
- PMC
- PMC6082428
- Cited by
- 77
- References
- 7
- Language
- en
- Licence
- Funders
- Cure Alzheimer's Fund
- National Institutes of Health (DP2NS083372-01)
- National Institute on Aging (RF1AG056296)
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