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Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

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Smith, Joan C., Sausville, Erin L., Girish, Vishruth, Yuan, Monet Lou, Vasudevan, Anand, John, Kristen M., Sheltzer, Jason M.·2020·Developmental Cell
DOI 10.1016/j.devcel.2020.05.012

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Abstract

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic smoke exposure triggers the expansion of this cell population and a concomitant increase in ACE2 expression. In contrast, quitting smoking decreases the abundance of these secretory cells and reduces ACE2 levels. Finally, we demonstrate that ACE2 expression is responsive to inflammatory signaling and can be upregulated by viral infections or interferon treatment. Taken together, these results may partially explain why smokers are particularly susceptible to severe SARS-CoV-2 infections. Furthermore, our work identifies ACE2 as an interferon-stimulated gene in lung cells, suggesting that SARS-CoV-2 infections could create positive-feedback loops that increase ACE2 levels and facilitate viral dissemination.

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Metadata

Authors
Smith, J. C., Sausville, E. L., Girish, V., Yuan, M. L., Vasudevan, A., John, K. M., & Sheltzer, J. M.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2020-06
Volume
53
Issue
5
Pages
514-529.e3
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2020.05.012
OpenAlex
W3024068183
Cited by
415
References
29
FWCI
11.29
Type
journal article
Language
en
Open access
bronze
Licence
Funders
National Institutes of Health

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CoChat. (2026). Citation check: Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. https://app.cochat.ai/papers/10.1016/j.devcel.2020.05.012
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Smith, J. C., Sausville, E. L., Girish, V., Yuan, M. L., Vasudevan, A., John, K. M., & Sheltzer, J. M. (2020). Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. Developmental Cell. https://doi.org/10.1016/j.devcel.2020.05.012

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