Curcumin: The story so far

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272

Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer

Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Harrington, A. M., Shields, P. G., Felley-Bosco, E., Hussain, S. P., & Harris, C. C. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.86 · Cited by 166

CURCUMIN: THE INDIAN SOLID GOLD

Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,647

Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects

Brglez Mojzer, E., Knez Hrnčič, M., Škerget, M., Knez, Ž., & Bren, U. (2016) · Molecules · doi:10.3390/molecules21070901 · Cited by 1,096

Dietary polyphenols and their biological significance

Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081

Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention

Huang, W.-Y., Cai, Y.-Z., & Zhang, Y. (2009) · Nutrition and Cancer · doi:10.1080/01635580903191585 · Cited by 1,009

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

Alao, J. P. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-24 · Cited by 871

Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 654

Encapsulation of curcumin in self-assembling peptide hydrogels as injectable drug delivery vehicles

Altunbas, A., Lee, S. J., Rajasekaran, S. A., Schneider, J. P., & Pochan, D. J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.069 · Cited by 497

Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective

Farzaei, M. H., Zobeiri, M., Parvizi, F., El-Senduny, F. F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S. M., Rahimi, R., & Abdollahi, M. (2018) · Nutrients · doi:10.3390/nu10070855 · Cited by 485

Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use

Elfahmi, Woerdenbag, H. J., & Kayser, O. (2014) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2014.01.002 · Cited by 468

Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor-κB Pathway

Lin, Y. G., Kunnumakkara, A. B., Nair, A., Merritt, W. M., Han, L. Y., Armaiz-Pena, G. N., Kamat, A. A., Spannuth, W. A., Gershenson, D. M., Lutgendorf, S. K., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3072 · Cited by 440

CLINICAL STUDIES WITH CURCUMIN

Hsu, C.-H., & Cheng, A.-L. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_21 · Cited by 398

PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms

Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., Wang, H., Zhou, Q., & Yu, S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202135j · Cited by 393

Dietary Polyphenols and Obesity

Meydani, M., & Hasan, S. T. (2010) · Nutrients · doi:10.3390/nu2070737 · Cited by 388

Polymeric micelles: nanocarriers for cancer-targeted drug delivery

Zhang, Y., Huang, Y., & Li, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0113-z · Cited by 367

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., & Priyadarsini, K. I. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.11.016 · Cited by 366

Complexation of curcumin with soy protein isolate and its implications on solubility and stability of curcumin

Tapal, A., & Tiku, P. K. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.025 · Cited by 349

Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism

Hassaninasab, A., Hashimoto, Y., Tomita-Yokotani, K., & Kobayashi, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016217108 · Cited by 300

Antimicrobial Potential of Curcumin: Therapeutic Potential and Challenges to Clinical Applications

Hussain, Y., Alam, W., Ullah, H., Dacrema, M., Daglia, M., Khan, H., & Arciola, C. R. (2022) · Antibiotics · doi:10.3390/antibiotics11030322 · Cited by 298

The pharmacology of curcumin: is it the degradation products?

Shen, L., & Ji, H.-F. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.01.004 · Cited by 295

Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity

Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X., & Lee, K. C. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.041 · Cited by 293

Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment

Sood, S., Jain, K., & Gowthamarajan, K. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.09.030 · Cited by 289

Combined effect of PLGA and curcumin on wound healing activity

Chereddy, K. K., Coco, R., Memvanga, P. B., Ucakar, B., des Rieux, A., Vandermeulen, G., & Préat, V. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.015 · Cited by 288

Transport of liposomal and albumin loaded curcumin to living cells: An absorption and fluorescence spectroscopic study

Kunwar, A., Barik, A., Pandey, R., & Priyadarsini, K. I. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.06.012 · Cited by 286

Effect of Cyclodextrin Complexation of Curcumin on its Solubility and Antiangiogenic and Anti-inflammatory Activity in Rat Colitis Model

Yadav, V. R., Suresh, S., Devi, K., & Yadav, S. (2009) · AAPS PharmSciTech · doi:10.1208/s12249-009-9264-8 · Cited by 282

Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability

Sun, J., Bi, C., Chan, H. M., Sun, S., Zhang, Q., & Zheng, Y. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.06.032 · Cited by 277

Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway

Li, M., Zhang, Z., Hill, D. L., Wang, H., & Zhang, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3066 · Cited by 274

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Giuffrida Stella, A. M., Schapira, T., Dinkova Kostova, A. T., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9775-9 · Cited by 268

Curcumin uptake and metabolism

Metzler, M., Pfeiffer, E., Schulz, S. I., & Dempe, J. S. (2013) · BioFactors · doi:10.1002/biof.1042 · Cited by 268

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study

Kooti, W., Servatyari, K., Behzadifar, M., Asadi-Samani, M., Sadeghi, F., Nouri, B., & Zare Marzouni, H. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587217696927 · Cited by 267

Chemical and Structural Features Influencing the Biological Activity of Curcumin

Indira Priyadarsini, K. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805289228 · Cited by 263

GSK-3β regulates cyclin D1 expression: A new target for chemotherapy

Takahashi-Yanaga, F., & Sasaguri, T. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.018 · Cited by 261

Curcumin use in pulmonary diseases: State of the art and future perspectives

Lelli, D., Sahebkar, A., Johnston, T. P., & Pedone, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.017 · Cited by 258

Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)

Lin, S.-S., Lai, K.-C., Hsu, S.-C., Yang, J.-S., Kuo, C.-L., Lin, J.-P., Ma, Y.-S., Wu, C.-C., & Chung, J.-G. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.037 · Cited by 254

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT)

Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., & Islam, F. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.002 · Cited by 230

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.001 · Cited by 216

PLGA based drug delivery systems: promising carriers for wound healing activity

Chereddy, K. K., Vandermeulen, G., & Préat, V. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12404 · Cited by 215

Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects

Coradini, K., Lima, F. O., Oliveira, C. M., Chaves, P. S., Athayde, M. L., Carvalho, L. M., & Beck, R. C. R. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.04.009 · Cited by 200

Neuroprotective and Neurorescue Effects of a Novel Polymeric Nanoparticle Formulation of Curcumin (NanoCurc™) in the Neuronal Cell Culture and Animal Model: Implications for Alzheimer's disease

Ray, B., Bisht, S., Maitra, A., Maitra, A., & Lahiri, D. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101374 · Cited by 177

Curcumin-graphene quantum dots for dual mode sensing platform: Electrochemical and fluorescence detection of APOe4, responsible of Alzheimer's disease

Mars, A., Hamami, M., Bechnak, L., Patra, D., & Raouafi, N. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.06.075 · Cited by 127

Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet

Senger, D. R., Li, D., Jaminet, S.-C., & Cao, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0148042 · Cited by 124

Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications

Udompornmongkol, P., & Chiang, B.-H. (2015) · Journal of Biomaterials Applications · doi:10.1177/0885328215594479 · Cited by 101

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

Isik, A. T., Celik, T., Ulusoy, G., Ongoru, O., Elibol, B., Doruk, H., Bozoglu, E., Kayir, H., Mas, M. R., & Akman, S. (2009) · AGE · doi:10.1007/s11357-008-9078-8 · Cited by 76

Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview

Raut, S., Bhalerao, A., Powers, M., Gonzalez, M., Mancuso, S., & Cucullo, L. (2023) · Cells · doi:10.3390/cells12162019 · Cited by 65

Resveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells

Hashemzaei, M., Tabrizian, K., Alizadeh, Z., Pasandideh, S., Rezaee, R., Mamoulakis, C., Tsatsakis, A., Skaperda, Z., Kouretas, D., & Shahraki, J. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.11.008 · Cited by 44

Diamond Nanoparticles Modify Curcumin Activity: In Vitro Studies on Cancer and Normal Cells and In Ovo Studies on Chicken Embryo Model

Strojny, B., Grodzik, M., Sawosz, E., Winnicka, A., Kurantowicz, N., Jaworski, S., Kutwin, M., Urbańska, K., Hotowy, A., Wierzbicki, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0164637 · Cited by 33

Research Mechanism and Progress of the Natural Compound Curcumin in Treating Alzheimer’s Disease

Li, L., Wang, F., Jia, X., Yao, L., & Liu, Y. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575263783231009051957 · Cited by 11