Antioxidant activities of crude extracts of fucoidan extracted from Sargassum glaucescens by a compressional-puffing-hydrothermal extraction process
Abstract
Fucoidan, a multifunctional marine polymer, is normally extracted from brown algae via extensive use of acid, solvent or high temperature water and a long reaction time. In present study, we developed a novel compressional-puffing-hydrothermal extraction (CPHE) process which primarily decomposes the cellular structure of algae and facilitates the release of fucoidan by hot water extraction. The CPHE process provides a number of advantages including simple procedure, reactant-saving, reduced pollution, and feasibility for continuous production. Sargassum glaucescens (SG) was utilized in this study, and the maximum extraction yield of polysaccharide was approximately 9.83 ± 0.11% (SG4). Thin layer chromatography (TLC), Fourier transform infrared (FTIR) analysis, and measurements of monosaccharide composition, fucose, sulfate, and uronic acid contents revealed that the extracted polysaccharide showed characteristics of fucoidan. All extracts exhibited antioxidant activities, and thus, further exploration of these extracts as potential natural and safe antioxidant agents is warranted.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A compressional-puffing-hydrothermal process modifies macroalgal cellular structure before fucoidan extraction.
“Other novel pre-treatments recently described in the literature include compressional-puffing-hydrothermal process consisting of heating at atmospheric pressure (140°C, 180°C and 220°C), followed by rapid reduction of pressure in a vessel containing superheated water, which allows the modification of the cellular structure of the macroalgae prior to extraction of fucoidan”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Huang, Wu, Yang, Kuan, & Chen, 2016
In vitro antioxidant activity of polysaccharides is mainly determined by DPPH, ABTS and FRAP assays.
“The in vitro antioxidant activity of polysaccharides have been determined mainly by 1,1diphenyl-2-picryl hydrazil (DPPH) radical scavenging, ABTS radical scavenging and ferric reducing antioxidant power (FRAP) assays amongst others”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Huang et al., 2016
Macroalgal polysaccharides display antiinflammatory, immunostimulatory, antioxidant, anticoagulant, antimicrobial, antiviral, antipeptic, antiadhesive, antiproliferative, antiapoptosis and antitumour properties.
“Macroalgal polysaccharides display a wide range of biological properties including antiinflammatory, immunostimulatory, antioxidant, anticoagulant, antimicrobial, antiviral, antipeptic, antiadhesive, antiproliferative, antiapoptosis and antitumour properties”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Huang et al., 2016
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269 · see citing works
Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion
Shimada, K., Fujikawa, K., Yahara, K., & Nakamura, T. (1992) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00018a005 · Cited by 3,208 · see citing works
Measurement of uronic acids without interference from neutral sugars
Filisetti-Cozzi, T. M. C. C., & Carpita, N. C. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90372-z · Cited by 1,446 · see citing works
Fucoidan: Structure and bioactivity
Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383 · see citing works
Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745 · see citing works
Duan, X.-J., Zhang, W.-W., Li, X.-M., & Wang, B.-G. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2004.12.015 · Cited by 628 · see citing works
Ponce, N. M. A., Pujol, C. A., Damonte, E. B., Flores, M. L., & Stortz, C. A. (2003) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00403-2 · Cited by 484 · see citing works
Wang, J., Zhang, Q., Zhang, Z., Song, H., & Li, P. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.10.015 · Cited by 456 · see citing works
Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed
Rodriguez-Jasso, R. M., Mussatto, S. I., Pastrana, L., Aguilar, C. N., & Teixeira, J. A. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.06.006 · Cited by 434 · see citing works
Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412 · see citing works
Gómez-Ordóñez, E., Jiménez-Escrig, A., & Rupérez, P. (2010) · Food Research International · doi:10.1016/j.foodres.2010.08.005 · Cited by 364 · see citing works
Binsan, W., Benjakul, S., Visessanguan, W., Roytrakul, S., Tanaka, M., & Kishimura, H. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.05.065 · Cited by 321 · see citing works
Nalinanon, S., Benjakul, S., Kishimura, H., & Shahidi, F. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.07.089 · Cited by 310 · see citing works
Novel procedures for the extraction of fucoidan from brown algae
Hahn, T., Lang, S., Ulber, R., & Muffler, K. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.06.016 · Cited by 297 · see citing works
Ale, M. T., Maruyama, H., Tamauchi, H., Mikkelsen, J. D., & Meyer, A. S. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.05.009 · Cited by 267 · see citing works
Huang, C.-Y., Kuo, J., Wu, S.-J., & Tsai, H.-T. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.066 · Cited by 264 · see citing works
Self-citationYang, C., Chung, D., Shin, I.-S., Lee, H., Kim, J., Lee, Y., & You, S. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2008.08.006 · Cited by 254 · see citing works
The determination of methylpentoses
Gibbons, M. (1955) · The Analyst · doi:10.1039/an9558000268 · Cited by 252 · see citing works
Holtkamp, A. D., Kelly, S., Ulber, R., & Lang, S. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1790-x · Cited by 175 · see citing works
A fucoidan fraction from Ascophyllum nodosum
Marais, M. F., & Joseleau, J. P. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00257-9 · Cited by 155 · see citing works
Effect of metal salts and fructose on the autoxidation of methyl linoleate in emulsions.
Yamauchi, R., Tatsumi, Y., Asano, M., et al. (1988) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.52.849 · Cited by 144 · see citing works
To grow and defend: lack of tradeoffs for brown algal phlorotannins
Arnold, T. M., & Targett, N. M. (2003) · Oikos · doi:10.1034/j.1600-0706.2003.11680.x · Cited by 107 · see citing works
Imbs, T. I., Skriptsova, A. V., & Николаевна, З. Т. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0293-7 · Cited by 107 · see citing works
Pandian, V., Vaseela, N., & Thirumaran, G. (2012) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(12)60082-x · Cited by 100 · see citing works
Biphasic effects of dietary antioxidants on oxidative stress-mediated carcinogenesis
Lee, K. W., & Lee, H. J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.01.021 · Cited by 99 · see citing works
Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats
Raghavendran, H. R. B., Periasamy, S., & Sathyanath, R. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.11.002 · Cited by 97 · see citing works
Inhibition of fish oil oxidation and the radical scavenging activity of New Zealand seaweed extracts
Kindleysides, S., Quek, S. Y., & Miller, M. R. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.068 · Cited by 92 · see citing works
Murakami, K., Yamaguchi, Y., Nöda, K., Fujii, T., Shinohara, N., Ushirokawa, T., Sugawa‐Katayama, Y., & Katayama, M. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.08.004 · Cited by 78 · see citing works
Radical scavenging activity of protein from tentacles of jellyfish Rhopilema esculentum
Yu, H., Liu, X., Xing, R., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.03.044 · Cited by 75 · see citing works
Varnalis, A. I., Brennan, J. G., & MacDougall, D. B. (2001) · Journal of Food Engineering · doi:10.1016/s0260-8774(00)00197-7 · Cited by 66 · see citing works
Composition and cytotoxicity of a novel polysaccharide from brown alga (Laminaria japonica)
Peng, Z., Liu, M., Fang, Z., et al. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.03.043 · Cited by 62 · see citing works
Zhao, X., Shizhu, D., Wang, J., Li, F., Chen, A., & Li, B. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.07.041 · Cited by 61 · see citing works
Chemical conversion of ginsenosides in puffed red ginseng
An, Y.-E., Ahn, S., Yang, D., et al. (2010) · LWT · doi:10.1016/j.lwt.2010.09.013 · Cited by 58 · see citing works
Honya, M., Kinoshita, T., Ishikawa, M., et al. (1993) · NIPPON SUISAN GAKKAISHI · doi:10.2331/suisan.59.295 · Cited by 58 · see citing works
A review of puffing processes for expansion of biological products
Payne, F. A., Taraba, J. L., & Saputra, D. (1989) · Journal of Food Engineering · doi:10.1016/0260-8774(89)90025-3 · Cited by 57 · see citing works
Isolation and Purification of Fucoidin from Brown SeaweedPelvetia wrightii
Anno, K., Terahata, H., Hayashi, Y., et al. (1966) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1966.10858624 · Cited by 18 · see citing works
Isolation and Purification of Fucoidin from Brown Seaweed Pelvetia wrightii
Anno, K., Terahata, H., Hayashi, Y., & Seno, N. (1966) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.30.495 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364 · see citing works
Saravana, P. S., Cho, Y.-J., Park, Y.-B., Woo, H.-C., & Chun, B.-S. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.08.014 · Cited by 197 · see citing works
Advances in pre-treatment techniques and green extraction technologies for bioactives from seaweeds
Ummat, V., Sivagnanam, S. P., Rajauria, G., O'Donnell, C., & Tiwari, B. K. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.01.018 · Cited by 126 · see citing works
Sheng, Y., Ma, Z., Wang, X., & Han, Y. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2021.131895 · Cited by 73 · see citing works
Hanjabam, M. D., Kumar, A., Tejpal, C. S., Krishnamoorthy, E., Kishore, P., & Ashok Kumar, K. (2019) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2019.100200 · Cited by 69 · see citing works
Anjana, K., & Arunkumar, K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135632 · Cited by 64 · see citing works
- Authors
- Huang, C.-Y., Wu, S.-J., Yang, W.-N., Kuan, A.-W., & Chen, C.-Y.
- Affiliations
- National Kaohsiung Marine University (TW)
- Chia Nan University of Pharmacy and Science (TW)
- Corresponding author
- Huang, Chun-Yung
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 197
- Pages
- 1121-1129
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2172728173
- Cited by
- 143
- References
- 38
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 6 · 2023: 15 · 2022: 22 · 2021: 17 · 2020: 16 · 2019: 16 · 2018: 21 · 2017: 11 · 2016: 5
- FWCI
- 19.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology
- NSC (101-2321-B-022-001-MY2)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, brown algae polysaccharides, antioxidant activity, hot water extraction, uronic acid, sulfate content, marine polysaccharides
- MeSH terms
- Antioxidants, Plant Extracts, Polysaccharides, Sargassum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review