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Enzyme-assisted extraction of carbohydrates from the brown alga Ecklonia radiata : Effect of enzyme type, pH and buffer on sugar yield and molecular weight profiles

Charoensiddhi, S., Lorbeer, A. J., Lahnstein, J., Bulone, V., Franco, C. M. M., & Zhang, W. Y. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.07.014 · Cited by 84 · see citing works

Studies on isolation, characterization of fucoidan from brown algae Turbinaria decurrens and evaluation of it's in vivo and in vitro anti-inflammatory activities

Manikandan, R., Duraisamy, P., Mahalakshmi, K., Manikandan, B., Arumugam, M., Janarthanan, S., Palanisamy, S., You, S., & Prabhu, N. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.152 · Cited by 84 · see citing works

Production of mannooligosaccharides from various mannans and evaluation of their prebiotic potential

Suryawanshi, R. K., & Kango, N. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127428 · Cited by 80 · see citing works

Fucoidan for cardiovascular application and the factors mediating its activities

Yao, Y., & Yim, E. K. F. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118347 · Cited by 80 · see citing works

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines

Marudhupandi, T., Kumar, T. T. A., Shanmugaasokan, L., Suja, G., & Vinothkumar, T. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.10.005 · Cited by 80 · see citing works

The Pharmacokinetics of Fucoidan after Topical Application to Rats

Pozharitskaya, O. N., Shikov, A. N., Obluchinskaya, E. D., & Vuorela, H. (2019) · Marine Drugs · doi:10.3390/md17120687 · Cited by 79 · see citing works

Fucoidan Extracted from the New Zealand Undaria pinnatifida—Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines

Lu, J., Shi, K., Chen, S., Wang, J., Hassouna, A., White, L. N., Mérien, F., Xie, M., Kong, Q., Li, J., et al. (2018) · Marine Drugs · doi:10.3390/md16120461 · Cited by 79 · see citing works

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

Azuma, K., Ishihara, T., Nakamoto, H., Amaha, T., Osaki, T., Tsuka, T., Imagawa, T., Minami, S., Takashima, O., Ifuku, S., et al. (2012) · Marine Drugs · doi:10.3390/md10102337 · Cited by 78 · see citing works

Antimicrobial, antioxidant and anticancer activities of Laurencia catarinensis , Laurencia majuscula and Padina pavonica extracts

Al-Enazi, N. M., Awaad, A. S., Zain, M. E., & Alqasoumi, S. I. (2017) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2017.11.001 · Cited by 77 · see citing works

Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells

Kim, K., Yoon, K.-Y., & Lee, B.-Y. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.09.014 · Cited by 75 · see citing works

Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo

Hwang, P., Yan, M., Lin, H. V., Li, K.-L., & Lin, Y. (2016) · Marine Drugs · doi:10.3390/md14070121 · Cited by 73 · see citing works

Structural characterization and bioactivities of sulfated polysaccharide from Monostroma oxyspermum

Seedevi, P., Moovendhan‬‬‬‬‬‬‬‬, M., Sadhasivam, S., Vasanthkumar, S., Srinivasan, A., Vairamani, S., & Shanmugam, A. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.09.062 · Cited by 73 · see citing works

Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins

Dimitrova‐Shumkovska, J., Krstanoski, L., & Veenman, L. (2020) · Marine Drugs · doi:10.3390/md18050242 · Cited by 73 · see citing works

Molecular weight and sulfate content modulate the inhibition of α-amylase by fucoidan relevant for type 2 diabetes management

Kim, K.-T., Rioux, L., & Turgeon, S. L. (2015) · PharmaNutrition · doi:10.1016/j.phanu.2015.02.001 · Cited by 71 · see citing works

Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

Kimura, R., Rokkaku, T., Takeda, S., Senba, M., & Mori, N. (2013) · Marine Drugs · doi:10.3390/md11114267 · Cited by 71 · see citing works

Anti-Proliferation Potential and Content of Fucoidan Extracted from Sporophyll of New Zealand Undaria pinnatifida

Mak, W., Wang, S. K., Liu, T., Hamid, N., Li, Y., Lu, J., & White, W. L. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00009 · Cited by 71 · see citing works

Isolation and purification of brown algae fucoidan from Sargassum siliquosum and the analysis of anti-lipogenesis activity

Wang, S.-H., Huang, C., Chen, C., Chang, C., Huang, C.-Y., Dong, C., & Chang, J. (2020) · Biochemical Engineering Journal · doi:10.1016/j.bej.2020.107798 · Cited by 70 · see citing works

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

Hwang, P., Hung, Y.-L., Phan, N. N., Hieu, B. T. N., Chang, P.-M., Li, K.-L., & Lin, Y. (2015) · Cytotechnology · doi:10.1007/s10616-015-9894-5 · Cited by 70 · see citing works

In vitro anticancer activity of polysaccharide extracted from red alga Jania rubens against breast and colon cancer cell lines

El-Sheekh, M. M., Gheda, S. F., & Abou‐Zeid, A. M. (2018) · Asian Pacific Journal of Tropical Medicine · doi:10.4103/1995-7645.244523 · Cited by 66 · see citing works

Hepatoprotective effect of the fucoidan from the brown seaweed Turbinaria tricostata

Chalé-Dzul, J. B., Moo-Puc, R. E., Robledo, D., & Freile‐Pelegrín, Y. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0429-9 · Cited by 63 · see citing works

The activation of NF-κB and MAPKs signaling pathways of RAW264.7 murine macrophages and natural killer cells by fucoidan from Nizamuddinia zanardinii

Tabarsa, M., Dabaghian, E. H., You, S., Yelithao, K., Cao, R., Rezaei, M., Alboofetileh, M., & Bita, S. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.125 · Cited by 63 · see citing works

Production of potential coproducts from microalgae

Hu, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64192-2.00014-7 · Cited by 62 · see citing works

In vitro anticancer potential of laminarin and fucoidan from Brown seaweeds

Sanniyasi, E., Gopal, R. K., Damodharan, R., Arumugam, A., Kumar, M. S., Senthilkumar, N., & Anbalagan, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-41327-7 · Cited by 62 · see citing works

Fucoidan-based nanomaterial and its multifunctional role for pharmaceutical and biomedical applications

Iqbal, M. W., Riaz, T., Mahmood, S., Bilal, M., Manzoor, M. F., Qamar, S. A., & Qi, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2106182 · Cited by 61 · see citing works

Seaweed minor constituents

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Rehashing Our Insight of Seaweeds as a Potential Source of Foods, Nutraceuticals, and Pharmaceuticals

Baghel, R. S., Choudhary, B., Pandey, S., Pathak, P. K., Patel, M. K., & Mishra, A. (2023) · Foods · doi:10.3390/foods12193642 · Cited by 60 · see citing works

Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus

Cabral, E. M., Mondala, J. R. M., Oliveira, M., Przyborska, J., Fitzpatrick, S., Rai, D. K., Saravana, P. S., García‐Vaquero, M., O′Shea, D., Devereux, M. M., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.06.182 · Cited by 58 · see citing works

Screening α-glucosidase inhibitors from four edible brown seaweed extracts by ultra-filtration and molecular docking

Xie, X., Chen, C., & Fu, X. (2020) · LWT · doi:10.1016/j.lwt.2020.110654 · Cited by 57 · see citing works

Optimization of citric acid treatment for the sequential extraction of fucoidan and alginate from Sargassum latifolium and their potential antioxidant and Fe(III) chelation properties

Fawzy, M. A., & Gomaa, M. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02453-9 · Cited by 57 · see citing works

Algal sulfated carrageenan inhibits proliferation of MDA-MB-231 cells via apoptosis regulatory genes

Murad, H., Ghannam, A., Al-Ktaifani, M. M., Abbas, A., & Hawat, M. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2915 · Cited by 57 · see citing works

Structural Characteristics and Biological Activity of Fucoidans from the Brown Algae <i>Alaria</i> sp. and <i>Saccharina japonica</i> of Different Reproductive Status

Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N. (2012) · Chemistry &amp; Biodiversity · doi:10.1002/cbdv.201100266 · Cited by 56 · see citing works

Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges

Wu, X., Xin, Y., Zhang, H., Liang, Q., & Ao, Q. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s460047 · Cited by 56 · see citing works

Enhancement of local plant immunity against tobacco mosaic virus infection after treatment with sulphated-carrageenan from red alga (Hypnea musciformis)

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Chemical structure of sulfated polysaccharides from brown seaweed (Turbinaria turbinata)

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Influence of molecular weight on the properties of Sargassum muticum fucoidan

Álvarez-Viñas, M., Flórez-Fernández, N., González‐Muñoz, M. J., & Domı́nguez, H. (2018) · Algal Research · doi:10.1016/j.algal.2018.101393 · Cited by 55 · see citing works

Recent Discoveries on Marine Organism Immunomodulatory Activities

Montuori, E., de Pascale, D., & Lauritano, C. (2022) · Marine Drugs · doi:10.3390/md20070422 · Cited by 54 · see citing works

Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum

Cho, M., Lee, D., Kim, J., & You, S. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.07.055 · Cited by 54 · see citing works

Effect of molecular weight of fucoidan on its anticancer-activity

Choi, J.-I. (2018) · Journal of Cancer Science & Therapy · Cited by 1 · see citing works

Effect of Hydrolyzed Fucoidan from The Brown Seaweed Sargassum Binderi Sonder Towards Human Breast Cancer T47d Cell Lines

Sinurat, E., Saepudin, E., & Qosthalani, F. A. (2017) · SQUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology · doi:10.15578/squalen.275 · Cited by 3 · see citing works

Fucoidan from brown seaweed Tubinaria decurrens: Structure and structure - anticancer activity relationship

Nguyen, A. N., Ngo, Q. V., Quach, T. T. M., Ueda, S., Yuguchi, Y., Matsumoto, Y., Kitamura, S., Ho, C. D., & Thanh, T. T. T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129326 · Cited by 38 · see citing works

Comparison of chemical composition, antioxidant and anticancer activity of different molecular weight fractions of fucoidan extract from Saccharina japonica

Wang, L., Liu, Y., Guo, S., Zhao, C., Li, K., Qin, Z., & Yue, Q. (2026) · 3 Biotech · doi:10.1007/s13205-026-04755-6

Physicochemical Characterization and Antitumor Activity of Fucoidan and Its Degraded Products from Sargassum hemiphyllum (Turner) C. Agardh

Luo, B., Wang, Z., Chen, J., Chen, X., Li, J., Li, Y., Li, R., Liu, X., Song, B., Cheong, K., et al. (2023) · Molecules · doi:10.3390/molecules28062610 · Cited by 22 · see citing works