The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons
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We show that most globus pallidus neurons, but very few neocortical interneurons, are generated from the ventral medial ganglionic eminence and dorsal preoptic area based on fate mapping using an Shh-Cre allele. The Shh-expressing subpallial lineage produces parvalbumin(+) GABAergic neurons, ChAT(+) cholinergic neurons, and oligodendrocytes. Loss of Nkx2-1 function from the Shh-expressing domain eliminated most globus pallidus neurons, whereas most cortical and striatal interneurons continued to be generated, except for striatal cholinergic neurons. Finally, our analysis provided evidence for a novel cellular component (Nkx2-1(-);Npas1(+)) of the globus pallidus.
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Generation of cortical interneurons is largely limited to the dorsal and intermediate MGE domains, while the ventrocaudal domain specializes in producing PV+ projection neurons for the globus pallidus.
“the generation of cortical interneurons is largely limited to the dorsal and intermediate domains of the MGE, whereas the ventrocaudal domain specializes in the production of PV+ projection neurons for the globus pallidus”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Flandin et al., 2010
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- Authors
- Flandin, P., Kimura, S., & Rubenstein, J. L. R.
- Affiliations
- University of California, San Francisco (US)
- National Institutes of Health (US)
- Corresponding author
- Rubenstein, John L. R.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-02-24
- Volume
- 30
- Issue
- 8
- Pages
- 2812-2823
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2865856
- OpenAlex
- W2047505539
- Cited by
- 176
- References
- 35
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 5 · 2018: 10 · 2017: 14 · 2016: 10 · 2015: 18 · 2014: 12 · 2013: 18 · 2012: 7
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Weston Havens Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (117463, 112882)
- National Institute of Mental Health (R01MH049428, MH049428, MH081880, R37MH049428, R01MH081880)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- TTF-1, globus pallidus, neocortical interneurons, fate mapping, parvalbumin interneurons, cholinergic neurons, oligodendrocytes, striatal interneurons, GABAergic neurons
- MeSH terms
- Thyroid Nuclear Factor 1, Acetylcholine, Animals, Animals, Newborn, Cell Differentiation, Choline O-Acetyltransferase, Corpus Striatum, Female, gamma-Aminobutyric Acid, Globus Pallidus, Interneurons, Male, Nuclear Proteins, Oligodendroglia, Stem Cells, Telencephalon, Transcription Factors, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Lineage, Neocortex, Mice, Hedgehog Proteins, Neurogenesis
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