Macrophages, Immunity, and Metabolic Disease

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 3×

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377

Targeting hepatic macrophages to treat liver diseases

Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.026 · Cited by 1,003

Macrophages: Development and Tissue Specialization

Varol, C., Mildner, A., & Jung, S. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112220 · Cited by 962

Skeletal muscle inflammation and insulin resistance in obesity

Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686

Tissue Tregs

Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: A randomised cross-over trial

Chambers, E. S., Byrne, C. S., Morrison, D. J., Murphy, K. G., Preston, T., Tedford, C., Garcia-Perez, I., Fountana, S., Serrano-Contreras, J. I., Holmes, E., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318424 · Cited by 443

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419

Ontogeny of Tissue-Resident Macrophages

Hoeffel, G., & Ginhoux, F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00486 · Cited by 364

Macrophages in obesity and non-alcoholic fatty liver disease: crosstalk with metabolism

Lefere, S., & Tacke, F. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.02.004 · Cited by 278

Metabolic inflammation in heart failure with preserved ejection fraction

Schiattarella, G. G., Rodolico, D., & Hill, J. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa217 · Cited by 284

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02492-2 · Cited by 278

Linking the Microbiota, Chronic Disease, and the Immune System

Hand, T. W., Vujkovic-Cvijin, I., Ridaura, V. K., & Belkaid, Y. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.08.003 · Cited by 247

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

Zheng, C., Sui, B., Zhang, X., Hu, J., Chen, J., Liu, J., Wu, D., Ye, Q., Xiang, L., Qiu, X., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12109 · Cited by 219

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

Mazur-Bialy, A. I., Pocheć, E., & Zarawski, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040701 · Cited by 203

Signals from the Adipose Microenvironment and the Obesity–Cancer Link—A Systematic Review

Himbert, C., Delphan, M., Scherer, D., Bowers, L. W., Hursting, S., & Ulrich, C. M. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0322 · Cited by 195

The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering

Yang, D., Xiao, J., Wang, B., Li, L., Kong, X., & Liao, J. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.109927 · Cited by 192

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Chung, K.-J., Chatzigeorgiou, A., Economopoulou, M., Garcia-Martin, R., Alexaki, V. I., Mitroulis, I., Nati, M., Gebler, J., Ziemssen, T., Goelz, S. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3728 · Cited by 175

Helios Controls a Limited Subset of Regulatory T Cell Functions

Sebastian, M., Lopez-Ocasio, M., Metidji, A., Rieder, S. A., Shevach, E. M., & Thornton, A. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501704 · Cited by 172

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Toubal, A., Kiaf, B., Beaudoin, L., Cagninacci, L., Rhimi, M., Fruchet, B., da Silva, J., Corbett, A. J., Simoni, Y., Lantz, O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17307-0 · Cited by 165

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

Alisson-Silva, F., Kawanishi, K., & Varki, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.07.002 · Cited by 156

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation

Ying, W., Tseng, A., Chang, R. C.-A., Morin, A., Brehm, T., Triff, K., Nair, V., Zhuang, G., Song, H., Kanameni, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81656 · Cited by 144

Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?

Bing, C. (2015) · Adipocyte · doi:10.4161/21623945.2014.979661 · Cited by 127

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

Price, N. L., Singh, A. K., Rotllan, N., Goedeke, L., Wing, A., Canfrán-Duque, A., Diaz-Ruiz, A., Araldi, E., Baldán, Á., Camporez, J.-P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.074 · Cited by 110

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95

Obesity associated disease risk: the role of inherent differences and location of adipose depots

Hill, J. H., Solt, C., & Foster, M. T. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0012 · Cited by 79

Deficiency of GATA3-Positive Macrophages Improves Cardiac Function Following Myocardial Infarction or Pressure Overload Hypertrophy

Yang, M., Song, L., Wang, L., Yukht, A., Ruther, H., Li, F., Qin, M., Ghiasi, H., Sharifi, B. G., & Shah, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.061 · Cited by 73

Macrophages in nonalcoholic fatty liver disease: a role model of pathogenic immunometabolism

Krenkel, O., & Tacke, F. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1604480 · Cited by 66

The Unique Phenotype of Lipid-Laden Macrophages

van Eijk, M., & Aerts, J. M. F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084039 · Cited by 63

Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus

Chen, K.-H. E., Lainez, N. M., Nair, M. G., & Coss, D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02183-2 · Cited by 38

Developmental programming of adult haematopoiesis system

Balistreri, C. R., Garagnani, P., Madonna, R., Vaiserman, A., & Melino, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100918 · Cited by 28

Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status

Huynh, K., Pernes, G., Mellett, N. A., Meikle, P. J., Murphy, A. J., & Lancaster, G. I. (2018) · Metabolites · doi:10.3390/metabo8020029 · Cited by 27

A novel strategy to dissect multifaceted macrophage function in human diseases

Karlinsey, K., Qu, L., Matz, A. J., & Zhou, B. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0522-685r · Cited by 23

Early effects of roflumilast on insulin sensitivity in adults with prediabetes and overweight/obesity involve age-associated fat mass loss – results of an exploratory study

Muo, I. M., MacDonald, S. D., Madan, R., Park, S.-J., Gharib, A. M., Martinez, P. E., Walter, M. F., Yang, S. B., Rodante, J. A., Courville, A. B., et al. (2019) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s182953 · Cited by 21

Checkpoint inhibitor treatment induces an increase in HbA1c in nondiabetic patients

Gauci, M.-L., Boudou, P., Squara, P.-A., Delyon, J., Allayous, C., Mourah, S., Resche-Rigon, M., Lebbé, C., Baroudjian, B., & Gautier, J.-F. (2019) · Melanoma Research · doi:10.1097/cmr.0000000000000585 · Cited by 10