C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay

Benzie, I. F. F., & Strain, J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 23,027 · see citing works

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works

A low-viscosity epoxy resin embedding medium for electron microscopy.

Spurr, A. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90033-1 · Cited by 13,268 · see citing works

[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal

Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,365 · see citing works

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

Chomczyński, P. (1993) · PubMed · Cited by 2,788 · see citing works

CD4+CD25+ suppressor T cells: more questions than answers

Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097 · see citing works

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858 · see citing works

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Baecher‐Allan, C., Brown, J. A., Freeman, G. J., & Hafler, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1245 · Cited by 1,857 · see citing works

Drug Discovery and Evaluation: Pharmacological Assays

(2014) · Springer eBooks · doi:10.1007/978-3-642-27728-3 · Cited by 1,408 · see citing works

Simplified method for silver staining of proteins in polyacrylamide gels and the mechanism of silver staining

Heukeshoven, J., & Dernick, R. (1985) · Electrophoresis · doi:10.1002/elps.1150060302 · Cited by 1,348 · see citing works

Advanced Oxidation Protein Products as Novel Mediators of Inflammation and Monocyte Activation in Chronic Renal Failure,

Witko‐Sarsat, V., Friedlander, M. A., Nguyen‐Khoa, T., Capeillère‐Blandin, C., Nguyen, A., Canteloup, S., Dayer, J., Jungers, P., Drüeke, T. B., & Descamps‐Latscha, B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.5.2524 · Cited by 879 · see citing works

C-Phycocyanin: A Biliprotein with Antioxidant, Anti-Inflammatory and Neuroprotective Effects

Romay, C., Gonzalez, R., Ledón, N., Remírez, D., & Rimbau, V. (2003) · Current Protein and Peptide Science · doi:10.2174/1389203033487216 · Cited by 718 · see citing works

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

Khoury, S. J., Hancock, W. W., & Weiner, H. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.5.1355 · Cited by 708 · see citing works

Antioxidants in relation to lipid peroxidation

Niki, E. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90052-1 · Cited by 677 · see citing works

Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae

Romay, C., Armesto, J., Remirez, D., González, R., Ledon, N., & García, I. (1998) · Inflammation Research · doi:10.1007/s000110050256 · Cited by 511 · see citing works

How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.

Steinman, L., & Zamvil, S. S. (2006) · Annals of Neurology · doi:10.1002/ana.20913 · Cited by 479 · see citing works

C-Phycocyanin: A potent peroxyl radical scavenger in Vivo and in Vitro

Bhat, V. B., & Madyastha, K. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3270 · Cited by 477 · see citing works

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis

Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450 · see citing works

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

Colotta, F., Polentarutti, N., Sironi, M., & Mantovani, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36956-x · Cited by 396 · see citing works

Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis

Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376 · see citing works

Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

Nantel, F., Denis, D., Gordon, R. J., Northey, A., Cirino, M. E. P., Metters, K. M., & Chan, C. C. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702866 · Cited by 334 · see citing works

Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis

Agnello, D., Bigini, P., Villa, P., Mennini, T., Cerami, A., Brines, M. L., & Ghezzi, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03239-0 · Cited by 334 · see citing works

Isolation and characterization of phycocyanins from the blue-green alga Spirulina platensis

Boussiba, S., & RICHMOND, A. E. (1979) · Archives of Microbiology · doi:10.1007/bf00409102 · Cited by 321 · see citing works

Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis

Haas, J., Fritzsching, B., Trübswetter, P., Korporal, M., Milkova, L., Fritz, B., Vobis, D., Krammer, P. H., Suri‐Payer, E., & Wildemann, B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1322 · Cited by 250 · see citing works

Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats

GONZÁLEZ, R., RODRÍGUEZ, S., ROMAY, GONZÁLEZ, A., ARMESTO, REMIREZ, D., & MERINO, N. (1999) · Pharmacological Research · doi:10.1006/phrs.1998.0409 · Cited by 220 · see citing works

C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages

Reddy, M. C., Subhashini, J., Mahipal, S. V. K., Bhat, V. B., Reddy, P. S., Kiranmai, G., Madyastha, K. M., & Reddanna, P. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00586-2 · Cited by 208 · see citing works

Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation

Romay, C., Ledón, N., & González, R. (1998) · Inflammation Research · doi:10.1007/s000110050338 · Cited by 195 · see citing works

Drug Discovery and Evaluation

(1997) · Springer eBooks · doi:10.1007/978-3-662-03333-3 · Cited by 185 · see citing works

Antiinflammatory and Antihyperalgesic Activity of C-Phycocyanin

Shih, C.-M., Cheng, S., Wong, C., Kuo, Y.-L., & Chou, T. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318193e919 · Cited by 143 · see citing works

Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar β-adrenergic function and increases in proinflammatory cytokines

Gemma, C., Mesches, M. H., Sepesi, B., Choo, K., Holmes, D. B., & Bickford, P. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06114.2002 · Cited by 143 · see citing works

AIRE and APECED: molecular insights into an autoimmune disease

Villaseñor, J., Benoist, C., & Mathis, D. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00246.x · Cited by 138 · see citing works

Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus

Rimbau, V., Camins, A., Romay, C., González, R., & Pallàs, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00792-2 · Cited by 130 · see citing works

Understanding CNS remyelination: Clues from developmental and regeneration biology

Franklin, R. J. M., & Hinks, G. L. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991015)58:2 · Cited by 110 · see citing works

Interferon-γ Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy

Feng, G. L., Wood, K. J., & Bushell, A. (2008) · Transplantation · doi:10.1097/tp.0b013e3181806a60 · Cited by 100 · see citing works

Cell therapy for autoimmune diseases

Dazzi, F., van Laar, J. M., Cope, A. P., & Tyndall, A. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2128 · Cited by 90 · see citing works

Reduced Foxp3 Protein Expression Is Associated with Inflammatory Disease during Human T Lymphotropic Virus Type 1 Infection

Oh, U., Grant, C. W., Griffith, C., Fugo, K., Takenouchi, N., & Jacobson, S. (2006) · The Journal of Infectious Diseases · doi:10.1086/503874 · Cited by 86 · see citing works

Role of histamine in the inhibitory effects of phycocyanin in experimental models of allergic inflammatory response

Remírez, D., Ledón, N., & González, R. (2002) · Mediators of Inflammation · doi:10.1080/09629350220131926 · Cited by 78 · see citing works

Inhibitory effects of Spirulina in zymosan‐induced arthritis in mice

Remírez, D., González, R., Merino, N., Rodriguez, S., & Ancheta, O. (2002) · Mediators of Inflammation · doi:10.1080/09629350220131917 · Cited by 77 · see citing works

Predominance of Type 1 cytokines and decreased number of CD4CD25 T regulatory cells in peripheral blood of patients with recurrent aphthous ulcerations

Lewkowicz, N., Lewkowicz, P., Banasik, M., Kurnatowska, A. J., & Tchórzewski, H. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.01.002 · Cited by 76 · see citing works

CD4+CD25+FoxP3+PD1— regulatory T cells in acute and stable relapsing‐remitting multiple sclerosis and their modulation by therapy

Saresella, M., Marventano, I., Longhi, R., Lissoni, F., Trabattoni, D., Mendozzi, L., Caputo, D., & Clerici, M. (2008) · The FASEB Journal · doi:10.1096/fj.08-110650 · Cited by 71 · see citing works

Plasma lipid peroxidation and progression of disability in multiple sclerosis

Koch, M., Mostert, J., Arutjunyan, A., Stepanov, M., Teelken, A., Heersema, D., & Keyser, J. D. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01739.x · Cited by 69 · see citing works

Phycocyanin Extract Reduces Leukotriene B4 Levels in Arachidonic Acid-induced Mouse-ear Inflammation Test

Romay, C., Ledón, N., & González, R. (1999) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357991772646 · Cited by 64 · see citing works

Influence of C-phycocyanin on hepatocellular parameters related to liver oxidative stress and Kupffer cell functioning

Remirez, D., Fernández, V., Tapia, G., González, R., & Videla, L. A. (2002) · Inflammation Research · doi:10.1007/pl00000314 · Cited by 63 · see citing works

Peroxidation Potential and Antioxidant Activity of Serum in Patients with Diabetes Mellitus and Myocard Infarction

Özdemirler, G., Mehmetçik, G., Öztezcan, S., Toker, G. A., Sıvas, A., & Uysal, M. (1995) · Hormone and Metabolic Research · doi:10.1055/s-2007-979938 · Cited by 63 · see citing works

C-Phycocyanin protects cerebellar granule cells from low potassium/serum deprivation-induced apoptosis

Rimbau, V., Camins, A., Pubill, D., Sureda, F. X., Romay, C., González, R., Jiménez, A., Escubedo, E., Camarasa, J., & Pallàs, M. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100100437 · Cited by 57 · see citing works

Chromatographic purification of biliproteins from Spirulina platensis high-performance liquid chromatographic separation of their α and β subunits

Bermejo, R., Talavera, E. M., Álvarez‐Pez, J. M., & Orte, J. C. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)00577-3 · Cited by 57 · see citing works

Effects of Phycocyanin Extract on Prostaglandin E2 Levels in Mouse Ear Inflammation Test

Romay, C., Ledón, N., & González, R. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300340 · Cited by 56 · see citing works

Comparison of the rabbit pyrogen test and Limulus amoebocyte lysate (LAL) assay for endotoxin in hepatitis B vaccines and the effect of aluminum hydroxide

Park, C., Jung, S.-H., Bak, J.-P., Lee, S.-S., & Rhee, D. (2005) · Biologicals · doi:10.1016/j.biologicals.2005.04.002 · Cited by 52 · see citing works

Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders

McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.061 · Cited by 47 · see citing works

A potent anti-oxidant property: fluorescent recombinant α-phycocyanin ofSpirulina

Guan, X., Zhang, W. J., Zhang, X. W., Li, Y., Wang, J. F., Lin, H., Tang, X., & Qin, S. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2008.04051.x · Cited by 36 · see citing works

The Janus Face of CD4+CD25+ Regulatory T Cells in Cancer and Autoimmunity

Danese, S., & Rutella, S. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780059599 · Cited by 34 · see citing works

Experimental Encephalomyelitis Induces Changes in DJ-1: Implications for Oxidative Stress in Multiple Sclerosis

Lev, N., Ickowicz, D., Barhum, Y., Blondheim-Shraga, N., Melamed, E., & Offen, D. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1987 · Cited by 32 · see citing works

Oxidant stress in the pathogenesis of multiple sclerosis

Луцкий, М. А., & Есауленко, И. Э. (2007) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-007-0003-x · Cited by 13 · see citing works

Nutraceutical properties of phycocyanin

Fernández-Rojas, B., Hernández‐Juárez, J., & Pedraza‐Chaverrí, J. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.011 · Cited by 293 · see citing works

Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications

Fernandes, R., Campos, J., Serra, M., Fidalgo, J., Almeida, H., Casas, A., Toubarro, D., & Barros, A. (2023) · Pharmaceuticals · doi:10.3390/ph16040592 · Cited by 255 · see citing works

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Liu, Q., Huang, Y., Zhang, R.-H., Cai, T., & Cai, Y. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/7803846 · Cited by 213 · see citing works

Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients

Delgado-Roche, L., Riera‐Romo, M., Mesta, F., Hernández-Matos, Y., Barrios, J. M., Martı́nez-Sánchez, G., & Al-Dalaien, S. M. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.06.017 · Cited by 137 · see citing works

Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Chen, H., Qi, H., & Xiong, P. (2022) · Marine Drugs · doi:10.3390/md20070450 · Cited by 129 · see citing works

Phycobilins and Phycobiliproteins Used in Food Industry and Medicine

Myśliwa‐Kurdziel, B., & Solymosi, K. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160912180155 · Cited by 105 · see citing works

Beneficial Effects of Spirulina Consumption on Brain Health

Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98 · see citing works

C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbils

Pentón‐Rol, G., Marín‐Prida, J., Andreu, G. L. P., Martı́nez-Sánchez, G., Acosta-Medina, E. F., Valdivia, A., Lagumersindez-Denis, N., Jiménez, E. R., Llopiz, A., López-Saura, P. A., et al. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.05.016 · Cited by 91 · see citing works

C-Phycocyanin prevents cisplatin-induced nephrotoxicity through inhibition of oxidative stress

Fernández-Rojas, B., Medina‐Campos, O. N., Hernández‐Pando, R., Negrette-Guzmán, M., Huerta‐Yépez, S., & Pedraza‐Chaverrí, J. (2014) · Food & Function · doi:10.1039/c3fo60501a · Cited by 91 · see citing works

Characterization and bioactivity of phycocyanin isolated from Spirulina maxima grown under salt stress

El‐Baky, H. H. A., & El‐Baroty, G. S. (2012) · Food & Function · doi:10.1039/c2fo10194g · Cited by 83 · see citing works

The role of regulatory T cells in neurodegenerative diseases

HeFeng, F. Q., & Balling, R. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1187 · Cited by 78 · see citing works

Microalgae: A Promising Source of Bioactive Phycobiliproteins

Tounsi, L., Hlima, H. B., Hentati, F., Hentati, O., Derbel, H., Michaud, P., & Abdelkafi, S. (2023) · Marine Drugs · doi:10.3390/md21080440 · Cited by 54 · see citing works

Beneficial effects of oral administration of C-Phycocyanin and Phycocyanobilin in rodent models of experimental autoimmune encephalomyelitis

Cervantes-Llanos, M., Lagumersindez-Denis, N., Marín-Prida, J., Pavón-Fuentes, N., Falcon-Cama, V., Piniella-Matamoros, B., Camacho-Rodríguez, H., Fernández-Massó, J. R., Valenzuela-Silva, C., Raíces-Cruz, I., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.032 · Cited by 73 · see citing works

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19-induced Damage to the Nervous System

Pentón-Rol, G., Marín-Prida, J., & McCarty, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210408123807 · Cited by 73 · see citing works

Potential Therapeutic Applications of C-Phycocyanin

Bannu, S. M., Lomada, D., Gulla, S., Chandrasekhar, T., Reddanna, P., & Reddy, M. C. (2019) · Current Drug Metabolism · doi:10.2174/1389200220666191127110857 · Cited by 73 · see citing works

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation

Sosa, R. A., Murphey, C. L., Robinson, R. R., & Forsthuber, T. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505955112 · Cited by 66 · see citing works

C-Phycocyanin protects against acute tributyltin chloride neurotoxicity by modulating glial cell activity along with its anti-oxidant and anti-inflammatory property: A comparative efficacy evaluation with N-acetyl cysteine in adult rat brain

Mitra, S., Siddiqui, W. A., & Khandelwal, S. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.06.016 · Cited by 67 · see citing works

Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats

Marín-Prida, J., Pavón-Fuentes, N., Llópiz-Arzuaga, A., Fernández-Massó, J. R., Delgado-Roche, L., Mendoza-Marí, Y., Santana, S. P., Cruz-Ramírez, A., Valenzuela-Silva, C., Nazábal-Gálvez, M., et al. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.021 · Cited by 61 · see citing works

C-phycocyanin Mitigates Cognitive Impairment in Doxorubicin-Induced Chemobrain: Impact on Neuroinflammation, Oxidative Stress, and Brain Mitochondrial and Synaptic Alterations

Wang, C., Zhao, Y., Wang, L., Pan, S., Liu, Y., Li, S., & Wang, D. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03164-2 · Cited by 61 · see citing works

C-Phycocyanin and Phycocyanobilin as Remyelination Therapies for Enhancing Recovery in Multiple Sclerosis and Ischemic Stroke: A Preclinical Perspective

Pentón-Rol, G., Marín-Prida, J., & Falcón-Cama, V. (2018) · Behavioral Sciences · doi:10.3390/bs8010015 · Cited by 50 · see citing works

C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+/phosphate-induced impairment

Marín‐Prida, J., Pentón‐Rol, G., Rodrigues, F. P., Alberici, L. C., Padovani, K. S., Leopoldino, A. M., Naal, Z., Polizello, A. C. M., Llopiz, A., Rosa, M. N., et al. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.08.011 · Cited by 48 · see citing works

Astragaloside IV regulates differentiation and induces apoptosis of activated CD4+ T cells in the pathogenesis of experimental autoimmune encephalomyelitis

Liu, Y., Xing, F., Han, X., Li, Q., Wu, H., Shi, H., Wang, Z., Huang, F., & Wu, X. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.10.024 · Cited by 44 · see citing works

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

Ciccone, L., Vandooren, J., Nencetti, S., & Orlandini, E. (2021) · Pharmaceuticals · doi:10.3390/ph14020086 · Cited by 36 · see citing works

Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice

Pentón-Rol, G., Lagumersindez-Denis, N., Muzio, L., Bergami, A., Furlan, R., Fernández-Massó, J. R., Nazabal-Galvez, M., Llópiz-Arzuaga, A., Herrera-Rolo, T., Veliz-Rodriguez, T., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9642-9 · Cited by 36 · see citing works

Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer’s disease

Piniella‐Matamoros, B., Marín‐Prida, J., & Pentón‐Rol, G. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00161-7 · Cited by 34 · see citing works

Total Flavonoids of Astragalus Inhibit Activated CD4+ T Cells and Regulate Differentiation of Th17/Th1/Treg Cells in Experimental Autoimmune Encephalomyelitis Mice by JAK/STAT and NFκB Signaling Pathways

Han, X., Xu, N., Yuan, J., Wu, H., Shi, H., Liu, Y., & Wu, X. (2023) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x23500568 · Cited by 29 · see citing works

Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

Jy, L., Wong, C.-Y., Koh, R. Y., Lim, C. L., Kok, Y.-Y., & Chye, S. M. (2024) · The Yale Journal of Biology and Medicine · doi:10.59249/jnkb9714 · Cited by 26 · see citing works

Phycobilins Versatile Pigments with Wide-Ranging Applications: Exploring Their Uses, Biological Activities, Extraction Methods and Future Perspectives

García‐Gómez, C., Aguirre-Cavazos, D. E., Chávez-Montes, A., Ballesteros-Torres, J. M., Orozco-Flores, A. A., Reyna-Martínez, G. R., Torres-Hernández, Á. D., González-Meza, G. M., Castillo, S., Garza, M. A. G., et al. (2025) · Marine Drugs · doi:10.3390/md23050201 · Cited by 24 · see citing works

C-Phycocyanin: A Phycobiliprotein from Spirulina with Metabolic Syndrome and Oxidative Stress Effects

Castro-Gerónimo, V. D., García-Rodríguez, R. V., Sánchez-Medina, A., Chamorro, G., Sánchez‐González, D. J., & Méndez-Bolaina, E. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.0113 · Cited by 20 · see citing works

Metabolites from marine microorganisms in cancer, immunity, and inflammation: A critical review

Riera‐Romo, M., Wilson-Savón, L., & Hernández, I. (2020) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres19.739_8.5.368 · Cited by 19 · see citing works

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

McCarty, M. F., DiNicolantonio, J. J., & Lerner, A. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s307549 · Cited by 18 · see citing works

Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward

Raghu, S. V., Kudva, A. K., Rao, S., Prasad, K., Mudgal, J., & Baliga, M. S. (2021) · Food & Function · doi:10.1039/d1fo02391h · Cited by 18 · see citing works

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Marín‐Prida, J., Fuentes, N. P., Lagumersindez-Denis, N., Camacho, H., García-Soca, A. M., Sarduy-Chávez, R. D. L. C., Vieira, É. L. M., Tavares, J. C., Falcón‐Cama, V., Fernández, J. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036200 · Cited by 18 · see citing works

Report on the Symposium “Molecular Mechanisms Involved in Neurodegeneration”

Pentón‐Rol, G., & Cervantes‐Llanos, M. (2018) · Behavioral Sciences · doi:10.3390/bs8010016 · Cited by 16 · see citing works

Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders

McCarty, M. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.08.041 · Cited by 15 · see citing works

The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome

Marín‐Prida, J., Rodríguez‐Ulloa, A., Besada, V., Llopiz, A., Batista, N. V., Hernández-González, I., Fuentes, N. P., Vieira, É. L. M., Falcón‐Cama, V., Acosta, E. F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1227268 · Cited by 13 · see citing works

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Ramos, V., Reis, M. A., Ferreira, L., Silva, A. M., Ferraz, R., Vieira, M., Vasconcelos, V. M., & Martins, R. F. (2023) · Biomolecules · doi:10.3390/biom13101444 · Cited by 12 · see citing works

Antioxidant Therapies in the Treatment of Multiple Sclerosis

Jiménez‐Jiménez, F. J., Alonso‐Navarro, H., Salgado-Cámara, P., García‐Martín, E., & Agúndez, J. A. G. (2024) · Biomolecules · doi:10.3390/biom14101266 · Cited by 11 · see citing works

Extraction, Purification, Bioactivity and Pharmacological Effects of Phycobiliproteins (PBPs): A Review

Madji, S., Antih, J., Tabib, M., Silvestre, C., Ghennai, A., Warnery, A., Vaillant, F. E., Bichon, F., Echalier, A., & Poucheret, P. (2025) · Analytica—A Journal of Analytical Chemistry and Chemical Analysis · doi:10.3390/analytica6040044 · Cited by 12 · see citing works

Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21

McCarty, M. F. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0057 · Cited by 10 · see citing works

Perspectives in immunopharmacology: The future of immunosuppression

Boraschi, D., & Pentón‐Rol, G. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.11.017 · Cited by 9 · see citing works

Bioactive Compounds of Algae: Potential Neuroprotective Agents in Neurodegenerative Disorders

Paranthaman, S., & Palraj, P. (2024) · Springer eBooks · doi:10.1007/978-981-99-7269-2_12 · Cited by 7 · see citing works

Increased levels of advanced oxidation protein products ( AOPPs ) were associated with nociceptive behavior and clinical scores in an experimental progressive autoimmune encephalomyelitis model ( PMS‐EAE )

Rodrigues, P., Frare, J. M., Peres, D. S., Viero, F. T., Ruviaro, N. A., Stein, C. D. S., Brum, E. D. S., Moresco, R. N., Oliveira, S. M., Bochi, G. V., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16081 · Cited by 6 · see citing works

Phycocyanin, The Microalgae Bio-Treasure

Campos, J., Fernandes, R., & Barros, A. (2024) · Food science and nutrition · doi:10.5772/intechopen.115108 · Cited by 6 · see citing works

Vaccination with heat-shocked mononuclear cells as a strategy for treating neurodegenerative disorders driven by microglial inflammation

McCarty, M. F., & Alharbi, S. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.08.003 · Cited by 5 · see citing works

Exploring the Neuroprotective Effects of Spirulina platensis: Insights Into Hemorrhagic Volume and Histological Outcomes

Almeida, T., Manfroi, G., Silva, S., Beggiora, P. D. S., Schwingel, D., & Bertolin, T. E. (2023) · Cureus · doi:10.7759/cureus.42078 · Cited by 5 · see citing works

Natural Products

Pentón‐Arias, E., & Haines, D. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803302-9.00011-7 · Cited by 5 · see citing works

Bioactive Compounds of the Genus Spirulina Can Prevent the Progression of Neurological Diseases

Elkader, H. A. E. A., Essawy, A. E., & Al‐Shami, A. S. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010057 · Cited by 4 · see citing works

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

Hayashi, O. (2012) · InTech eBooks · doi:10.5772/48322 · Cited by 4 · see citing works

C-Phycocyanin and Phycocyanobilin for neuroprotection: a deep dive into the biological processes involved

Pentón‐Rol, G., Marín‐Prida, J., Sarduy-Chávez, R. D. L. C., & Hernández-González, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00016-6 · Cited by 3 · see citing works

Nutraceutical and dietary measures with potential for preventing/controlling non-alcoholic fatty liver disease and its complications

Luján, L. M. L., McCarty, M. F., Galvez-Ruiz, J. C., López, S. T., & Assanga, S. B. I. (2024) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2024.200281 · Cited by 3 · see citing works

Spirulina platensis Alleviates the Liver, Brain and Heart Oxidative Stress in Type 1 Diabetic Rats

Garcia, F. A. D. O., Yuen, V. G., Sales‐Campos, H., Turatti, E., Viana, G. S. D. B., Oliveira, C. J. F., & McNeill, J. H. (2018) · Food and Nutrition Sciences · doi:10.4236/fns.2018.96056 · Cited by 3 · see citing works

Nutraceutical Compounds from Marine Microalgae

Renugadevi, K., Nachiyar, C. V., Nellore, J., Sunkar, S., & Namasivayam, S. K. R. (2022) · doi:10.1002/9781119746843.ch12 · Cited by 3 · see citing works

C-phycocyanin acts as a positive immunomodulator in different primary and secondary organs of mice

Salgado, M. T. S. F., Silva, M. C. S., da Silva, R. C., Campos, M. L., Fratelli, C., Braga, A. R. C., Stockler‐Pinto, M. B., Votto, A. P. D. S., & de Paiva, L. S. (2025) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2448801 · Cited by 2 · see citing works

Content of Phycobilin Pigments in Two Strains of Cyanobacteria of the Atacama Desert, Chile

Pereira, I. (2014) · SOJ Microbiology & Infectious Diseases · doi:10.15226/sojmid/2/3/00121 · Cited by 2 · see citing works

Purificación y caracterización de la ficocianobilina

Ecuador., D. D. C. Q. C. D. I. E. B. U. D. L. A. Q., & Llopiz, A. (2016) · Bionatura · doi:10.21931/rb/2016.01.04.8 · Cited by 2 · see citing works

One structure, multiple features: The phycocyanin in biotechnology

Chentir, I., & Nasri, M. (2020) · Nutrition & Santé · doi:10.30952/9.1.4 · Cited by 2 · see citing works

Neuroprotective potential of phycocyanobilin and C-phycocyanin: from molecular targets to translational applications

Delgado-Lora, S., Rodríguez‐Álvarez, Y., & Pentón‐Rol, G. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004143 · Cited by 1 · see citing works

Protective effects of CPhycocyanin against lipid p eroxidation of serum lipoproteins and hepatic microsomes.

Roche, L. D., Lagumersindez-Denis, N., Llopiz, A., Pentón‐Arias, E., & Pentón‐Rol, G. (2011) · Cited by 1 · see citing works

Pharmacological Strategies Using Biologics as Immunomodulatory Agents

Boraschi, D., & Pentón‐Rol, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803302-9.00001-4 · Cited by 1 · see citing works

Therapeutic potential of spirulina and its bioactive compound phycocyanin in neuropsychiatric disorders

Taheri, A. T., Motamedzadeh, A., Zahedi, E., Farasat, A., Dadgostar, E., Aschner, M., Khanifar, H., Rahmati‐Dehkordi, F., & Tamtaji, O. R. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12532-0 · Cited by 1 · see citing works

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Marín‐Prida, J., Fuentes, N. P., Lagumersindez-Denis, N., Camacho, H., García-Soca, A. M., Sarduy-Chávez, R. D. L. C., Vieira, É. L. M., Tavares, J. C., Falcón‐Cama, V., Fernández, J. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036200 · Cited by 18 · see citing works

Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice

Pentón-Rol, G., Lagumersindez-Denis, N., Muzio, L., Bergami, A., Furlan, R., Fernández-Massó, J. R., Nazabal-Galvez, M., Llópiz-Arzuaga, A., Herrera-Rolo, T., Veliz-Rodriguez, T., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9642-9 · Cited by 36 · see citing works

Beneficial effects of oral administration of C-Phycocyanin and Phycocyanobilin in rodent models of experimental autoimmune encephalomyelitis

Cervantes-Llanos, M., Lagumersindez-Denis, N., Marín-Prida, J., Pavón-Fuentes, N., Falcon-Cama, V., Piniella-Matamoros, B., Camacho-Rodríguez, H., Fernández-Massó, J. R., Valenzuela-Silva, C., Raíces-Cruz, I., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.032 · Cited by 73 · see citing works

Inhibition of Endogenous Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis by Inducing Myeloid-Derived Suppressor Cells

Alabanza, L. M., Esmon, N. L., Esmon, C. T., & Bynoe, M. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202556 · Cited by 33 · see citing works

Primaquine elicits Foxp3+ regulatory T cells with a superior ability to limit CNS autoimmune inflammation.

Thomé, R., Casella, G., Lotfi, N., Ishikawa, L., Wang, Q., Ciric, B., Zhang, G.-X., & Rostami, A. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102505 · Cited by 5 · see citing works