Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus
Abstract
The neuroprotective role of C-phycocyanin was examined in kainate-injured brains of rats. The effect of three different treatments with C-phycocyanin was studied. The incidence of neurobehavioral changes was significantly lower in animals receiving C-phycocyanin. These animals also gained significantly more weight than the animals only receiving kainic acid, whereas their weight gain did not differed significantly from controls. Equivalent results were found when the neuronal damage in the hippocampus was evaluated through changes in peripheral benzodiazepine receptors (microglial marker) and heat shock protein 27 kD expression (astroglial marker). Our results are consistent with the oxygen radical scavenging properties of C-phycocyanin described elsewhere. Our findings and the virtual lack of toxicity of C-phycocyanin suggest this drug could be used to treat oxidative stress-induced neuronal injury in neurodegenerative diseases, such as Alzheimer's and Parkinson's.
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Oral administration of C-PC decreased the activation of microglia and astrocytes caused by kainic acid in rats.
“Moreover, oral administration of C-PC also decreased the activation of microglia and astrocytes caused by kainic acid in rats [85],”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [85]
Oral treatment with C-PC shows its effect in the hippocampus, crossing the BBB.
“An interesting aspect is that oral treatment with C-PC shows its effect in the hippocampus, crossing BBB [85].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [85]
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- Authors
- Rimbau, V., Camins, A., Romay, C., González, R., & Pallàs, M.
- Affiliations
- Universitat de Barcelona (ES)
- Centro Nacional de Investigaciones Científicas (CU)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 276
- Issue
- 2
- Pages
- 75-78
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2116589941
- Cited by
- 130
- References
- 18
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- C-phycocyanin, kainic acid, excitotoxicity, neuroprotection, hippocampus, oxidative stress, neurobehavioral abnormalities, translocator protein (TSPO), HSP27, microglia, astrocytes, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease
- MeSH terms
- Animals, Astrocytes, Body Weight, Heat-Shock Proteins, Hippocampus, Kainic Acid, Male, Phycocyanin, Receptors, GABA-A, Rats, Sprague-Dawley, Microglia, Kainic Acid Receptors, Neuroprotective Agents, Rats
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