Cited by 259Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Measured Gene-by-Environment Interaction in Relation to Attention-Deficit/Hyperactivity Disorder

Open access

Nigg, Joel, Nikolas, Molly, Burt, S. Alexandra·2010·Journal of the American Academy of Child & Adolescent Psychiatry

DOI 10.1016/j.jaac.2010.01.025PMC PMC2928573

Open this paper in CoChat — free account

Abstract

Objective To summarize and evaluate the state of knowledge regarding the role of measured gene-by-environment interactions in relation to attention-deficit/hyperactivity disorder.Method A selective review of methodologic issues was followed by a systematic search for relevant articles on measured gene-by-environment interactions; the search yielded 16 studies, which are discussed in qualitative fashion.Results Relatively consistent evidence points to the interaction of genotype with psychosocial factors in the development of attention-deficit/hyperactivity disorder. The next step is to identify the mechanisms on the environment side and the gene combinations on the genetic side accounting for this effect. In contrast, evidence for gene-by-environment interactions involving pre- and perinatal risk factors is generally negative or unreplicated. The aggregate effect size for psychosocial interaction with genotype is more than double that for the interaction of pre- and perinatal risks with genotype. Only a small fraction of candidate environments and gene markers has been studied, and multivariate methods to integrate multiple gene or environment markers have yet to be implemented.Conclusions Gene-by-environment interaction appears likely to prove fruitful in understanding the etiology of attention-deficit/hyperactivity disorder. Findings to date already suggest new avenues of investigation particularly involving psychosocial mechanisms and their interplay with genotype. Further pursuit of theoretically promising leads is recommended.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jaac.2010.01.025

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655
MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Variance Components Models for Gene–Environment Interaction in Twin Analysis
Purcell, S. (2002) · Twin Research · doi:10.1375/136905202762342026 · Cited by 924 · cited 1×
“(1) The DRD4 Exon III VNTR (a 48 base pair repeat often referred to by the number of repeats, such as the “7 repeat” or “4-repeat” variant) generally yielded negative findings, but did show unreplicated interactions with season of birth and with maternal smoking.”
Background
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784
Maternal Lifestyle Factors in Pregnancy Risk of Attention Deficit Hyperactivity Disorder and Associated Behaviors: Review of the Current Evidence
Linnet, K. M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T. B., Rodriguez, A., Kotimaa, A., Moilanen, I., Thomsen, P. H., Olsen, J., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1028 · Cited by 778
Genetic influences on measures of the environment: a systematic review
KENDLER, K. S., & BAKER, J. H. (2007) · Psychological Medicine · doi:10.1017/s0033291706009524 · Cited by 725
Developmental Psychopathology
Levine, M. P., & Smolak, L. (2006) · Psychology Press eBooks · doi:10.4324/9781410613189-11 · Cited by 697
Environmental risk factors for attention‐deficit hyperactivity disorder
Banerjee, T. D., Middleton, F., & Faraone, S. V. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00430.x · Cited by 575
Prenatal Stress and Risk for Psychopathology: Specific Effects or Induction of General Susceptibility?
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473

Flagged first, then by citations

Show all 60 references

Research works printed but not linked: 1

Fine, 1981, Immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis, Int J Lepr Other Mycobact Dis, 49, 437

Sorted by citations

Attention-deficit hyperactivity disorder
Posner, J., Polanczyk, G. V., & Sonuga-Barke, E. (2020) · The Lancet · doi:10.1016/s0140-6736(19)33004-1 · Cited by 835
Practitioner Review: What have we learnt about the causes of ADHD?
Thapar, A., Cooper, M., Eyre, O., & Langley, K. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02611.x · Cited by 701
A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD)
Luo, Y., Weibman, D., Halperin, J. M., & Li, X. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00042 · Cited by 394
“Genes and environment do not work independently of each other (Nigg et al., 2010).”
Background
Media use and ADHD-related behaviors in children and adolescents: A meta-analysis
Nikkelen, S. W. C., Valkenburg, P. M., Huizinga, M., & Bushman, B. J. (2014) · Developmental Psychology · doi:10.1037/a0037318 · Cited by 339
Sexual selection and sex differences in the prevalence of childhood externalizing and adolescent internalizing disorders.
Martel, M. M. (2013) · Psychological Bulletin · doi:10.1037/a0032247 · Cited by 348
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299
Parenting in adults with attention-deficit/hyperactivity disorder (ADHD)
Johnston, C., Mash, E. J., Miller, N. V., & Ninowski, J. E. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.01.007 · Cited by 329
The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): What every clinician should know
Cortese, S. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2012.01.009 · Cited by 335
Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives
Nigg, J. T., Lewis, K., Edinger, T., & Falk, M. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.10.015 · Cited by 260
Update on Environmental Risk Factors for Attention-Deficit/Hyperactivity Disorder
Froehlich, T. E., Anixt, J. S., Loe, I. M., Chirdkiatgumchai, V., Kuan, L., & Gilman, R. C. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0221-3 · Cited by 236
Attention‐deficit hyperactivity disorder ( ADHD ): an updated review of the essential facts
Tarver, J., Daley, D., & Sayal, K. (2014) · Child: Care, Health and Development · doi:10.1111/cch.12139 · Cited by 234
Influence of relative age on diagnosis and treatment of attention-deficit/hyperactivity disorder in children
Morrow, R. L., Garland, E., Wright, J. M., Maclure, M., Taylor, S., & Dormuth, C. R. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.111619 · Cited by 230
Environmental risk factors by gender associated with attention-deficit/hyperactivity disorder
Silva, D., Colvin, L., Hagemann, E., & Bower, C. (2014) · PEDIATRICS · doi:10.1542/peds.2013-1434 · Cited by 201
Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials
Hawkey, E., & Nigg, J. T. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.05.005 · Cited by 160
Preventive Interventions for ADHD: A Neurodevelopmental Perspective
Halperin, J. M., Bedard, A., & Curchack, J. T. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0123-z · Cited by 151
Diet and ADHD, Reviewing the Evidence: A Systematic Review of Meta-Analyses of Double-Blind Placebo-Controlled Trials Evaluating the Efficacy of Diet Interventions on the Behavior of Children with ADHD
Pelsser, L. M., Frankena, K., Toorman, J., & Rodrigues Pereira, R. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169277 · Cited by 145
Neurobiology of Attention Deficit/Hyperactivity Disorder
Purper‐Ouakil, D., Ramoz, N., Lepagnol-Bestel, A.-M., Gorwood, P. A. P. M., & Simonneau, M. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212b40f · Cited by 160
Toward a revised nosology for attention-deficit/hyperactivity disorder heterogeneity
Nigg, J. T., Karalunas, S. L., Feczko, E., & Fair, D. A. (2020) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.02.005 · Cited by 132
Does serotonin deficit mediate susceptibility to ADHD?
Banerjee, E., & Nandagopal, K. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.02.001 · Cited by 133
Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR 2
Wilmot, B., Fry, R. C., Smeester, L., Musser, E. D., Mill, J. S., & Nigg, J. T. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12457 · Cited by 122
Genetic risk factors and gene–environment interactions in adult and childhood attention-deficit/hyperactivity disorder
Palladino, V. S., McNeill, R. V., Reif, A., & Kittel‐Schneider, S. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000220 · Cited by 123
Early life exposure to perfluoroalkyl substances (PFAS) and ADHD: a meta-analysis of nine European population-based studies
Forns, J., Verner, M.-A., Iszatt, N., Nowack, N., Bach, C. C., Vrijheid, M., Costa, O., Andiarena, A., Sovcikova, E., Høyer, B. B., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5444 · Cited by 99
Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study of Mexican Children
Huang, S., Hu, H., Sánchez, B. N., Peterson, K. E., Ettinger, A. S., Lamadrid‐Figueroa, H., Schnaas, L., Mercado‐García, A., Wright, R. O., Basu, N., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1510067 · Cited by 100
Attention‐Deficit/Hyperactivity Disorder (ADHD): Interaction between socioeconomic status and parental history of ADHD determines prevalence
Rowland, A. S., SKIPPER, B. J., Rabiner, D. L., Qeadan, F., Campbell, R. A., Naftel, A. J., & Umbach, D. M. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12775 · Cited by 98
Epigenetics in Developmental Disorder: ADHD and Endophenotypes
Archer, T., & Oscar‐Berman, M. (2011) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000104 · Cited by 94
Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches
Kim, J.-W., Sharma, V., & Ryan, N. D. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv052 · Cited by 89
Gene-Environment Interactions in ADHD: The Roles of SES and Chaos
Gould, K. L., Coventry, W. L., Olson, R. K., & Byrne, B. (2017) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0268-7 · Cited by 88
The Dopamine Receptor D4 Gene (DRD4) Moderates Family Environmental Effects on ADHD
Martel, M. M., Nikolas, M. A., Jernigan, K. A., Friderici, K. H., Waldman, I. D., & Nigg, J. T. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9439-5 · Cited by 90
Maternal anxiety, depression and sleep disorders before and during pregnancy, and preschool ADHD symptoms in the NINFEA birth cohort study
Vizzini, L., Popovic, M., Zugna, D., Vitiello, B., Trevisan, M., Pizzi, C., Rusconi, F., Gagliardi, L., Merletti, F., & Richiardi, L. (2018) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796018000185 · Cited by 69
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
Nemoda, Z., Szekely, A., & Sasvari-Szekely, M. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.002 · Cited by 78
Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder
Albrecht, B., Brandeis, D., Uebel, H., Valko, L., Heinrich, H., Drechsler, R., Heise, A., Müller, U. C., Steinhausen, H. ‐., Rothenberger, A., et al. (2012) · Psychological Medicine · doi:10.1017/s003329171200270x · Cited by 83
Future Directions in ADHD Etiology Research
Nigg, J. T. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.686870 · Cited by 85
Association between ambient gaseous and particulate air pollutants and attention deficit hyperactivity disorder (ADHD) in children; a systematic review
Aghaei, M., Janjani, H., Yousefian, F., Jamal, A., & Yunesian, M. (2019) · Environmental Research · doi:10.1016/j.envres.2019.03.030 · Cited by 78
The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants
Mergy, M. A., Gowrishankar, R., Gresch, P. J., Gantz, S. C., Williams, J. T., Davis, G. L., Wheeler, C. A., Stanwood, G. D., Hahn, M. K., & Blakely, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417294111 · Cited by 71
The genetics of reading disabilities: from phenotypes to candidate genes.
Raskind, W. H., Peter, B., Richards, T., Eckert, M. M., & Berninger, V. W. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00601 · Cited by 71
Are fetal growth impairment and preterm birth causally related to child attention problems and ADHD? Evidence from a comparison between high-income and middle-income cohorts
Murray, E. L., Pearson, R. M., Fernandes, M., Santos, I. S., Barros, F. C., Victora, C. G., Stein, A. L., & Matijasevich, A. (2016) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2015-206222 · Cited by 69
Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe
Forns, J., Sunyer, J., García‐Esteban, R., Porta, D., Ghassabian, A., Giorgis-Allemand, L., Gong, T., Gehring, U., Sørensen, M., Standl, M., et al. (2018) · Epidemiology · doi:10.1097/ede.0000000000000874 · Cited by 69
Pre- and Perinatal Ischemia-Hypoxia, the Ischemia-Hypoxia Response Pathway, and ADHD Risk
Smith, T. F., Schmidt‐Kastner, R., McGeary, J. E., Kaczorowski, J. A., & Knopik, V. S. (2016) · Behavior Genetics · doi:10.1007/s10519-016-9784-4 · Cited by 70
Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: A prospective investigation
Gustafsson, H., Sullivan, E. L., Battison, E., Holton, K. F., Graham, A. M., Karalunas, S. L., Fair, D. A., Loftis, J. M., & Nigg, J. T. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.019 · Cited by 66
Exposure to environmental and lifestyle factors and attention-deficit / hyperactivity disorder in children - a review of epidemiological studies
Polańska, K., Jurewicz, J., & Hanke, W. (2012) · International Journal of Occupational Medicine and Environmental Health · doi:10.2478/s13382-012-0048-0 · Cited by 65
Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications
Musci, R. J., Augustinavicius, J., & Volk, H. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1065-5 · Cited by 53
Developments and challenges in the diagnosis and treatment of ADHD
Dias, T. G. C., Kieling, C., Graeff-Martins, A. S., Moriyama, T. S., Rohde, L. A., & Polanczyk, G. V. (2013) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2013-s103 · Cited by 62
The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis
Jenabi, E., Bashirian, S., Khazaei, S., & Basiri, Z. (2019) · Korean Journal of Pediatrics · doi:10.3345/kjp.2019.00185 · Cited by 61
A Potential Role for Neuroinflammation in ADHD
Vázquez-González, D., Carreón-Trujillo, S., Álvarez‐Arellano, L., Abarca-Merlin, D. M., Domínguez-López, P., Salazar–García, M., & Corona, J. C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_15 · Cited by 65
Accounting for the shared environment in cognitive abilities and academic achievement with measured socioecological contexts
Engelhardt, L. E., Church, J. A., Harden, K. P., & Tucker–Drob, E. M. (2018) · Developmental Science · doi:10.1111/desc.12699 · Cited by 65
Genetics of attention-deficit/hyperactivity disorder: current findings and future directions
Akutagava‐Martins, G. C., Salatino‐Oliveira, A., Kieling, C., Rohde, L. A., & Hutz, M. H. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.30 · Cited by 64
Prenatal exposure to cigarette smoke or alcohol and cerebellum volume in attention-deficit/hyperactivity disorder and typical development
de Zeeuw, P., Zwart, F. M., Schrama, R., van Engeland, H., & Durston, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.12 · Cited by 59
Observed temperament from ages 6 to 36 months predicts parent- and teacher-reported attention-deficit/hyperactivity disorder symptoms in first grade
Willoughby, M. T., Gottfredson, N. C., Stifter, C. A., & The Family Life Project Investigators (2016) · Development and Psychopathology · doi:10.1017/s0954579415001236 · Cited by 55
Omega-3 Long-Chain Polyunsaturated Fatty Acids Intake in Children with Attention Deficit and Hyperactivity Disorder
Fuentes-Albero, M., Martínez, M., & Cauli, O. (2019) · Brain Sciences · doi:10.3390/brainsci9050120 · Cited by 51
ADHD pharmacogenetics across the life cycle: New findings and perspectives
Bruxel, E. M., Akutagava-Martins, G. C., Salatino-Oliveira, A., Contini, V., Kieling, C., Hutz, M., & Rohde, L. (2014) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32240 · Cited by 44
Attention deficits and hyperactivity–impulsivity: What have we learned, what next?
Nigg, J. T. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000734 · Cited by 51
Predicting ADHD by assessment of Rutter’s indicators of adversity in infancy
Østergaard, S. D., Larsen, J. T., Dalsgaard, S., Wilens, T. E., Mortensen, P. B., Agerbo, E., Mors, O., & Petersen, L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157352 · Cited by 50
ADHD co-morbidities: A review of implication of gene × environment effects with dopamine-related genes
Kanarik, M., Grimm, O., Mota, N. R., Reif, A., & Harro, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104757 · Cited by 53
Brain Correlates of the Interaction Between 5-HTTLPR and Psychosocial Stress Mediating Attention Deficit Hyperactivity Disorder Severity
van der Meer, D., Hoekstra, P. J., Zwiers, M. P., Mennes, M., Schweren, L., Franke, B., Heslenfeld, D. J., Oosterlaan, J., Faraone, S. V., Buitelaar, J. K., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14081035 · Cited by 49
Factors Influencing Parental Decision Making About Stimulant Treatment for Attention-Deficit/Hyperactivity Disorder
Ahmed, R. A., McCaffery, K. J., & Aslani, P. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0087 · Cited by 45
Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder
Rosenberg, J., Pennington, B. F., Willcutt, E. G., & Olson, R. K. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02452.x · Cited by 45
Media Violence and Children's ADHD-Related Behaviors: A Genetic Susceptibility Perspective
Nikkelen, S. W. C., Vossen, H. G. M., Valkenburg, P. M., Velders, F. P., Windhorst, D. A., Jaddoe, V. W. V., Albert Hofman, D., Verhulst, F. C., & Tiemeier, H. W. (2014) · Journal of Communication · doi:10.1111/jcom.12073 · Cited by 43
The Impact of Coexisting Emotional and Conduct Problems on Family Functioning and Quality of Life Among Adolescents With ADHD
Schei, J., Jozefiak, T., Nøvik, T. S., Lydersen, S., & Indredavik, M. S. (2013) · Journal of Attention Disorders · doi:10.1177/1087054713507976 · Cited by 45
Neuropsychological functioning and severity of ADHD in early childhood: A four-year cross-lagged study.
Rajendran, K., Rindskopf, D., O'Neill, S., Marks, D. J., Nomura, Y., & Halperin, J. M. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0034237 · Cited by 41
Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder
Østergaard, S. D., Trabjerg, B. B., Als, T. D., Albiñana, C., Privé, F., Vilhjálmsson, B. J., Bækvad‐Hansen, M., Bybjerg‐Grauholm, J., HOUGAARD, D. M., Nordentoft, M., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01019-6 · Cited by 42
Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study
Kieling, C., Hutz, M. H., Genro, J. P., Polanczyk, G. V., Anselmi, L., Camey, S. A., Hallal, P. C., Barros, F. C., Victora, C. G., Menezes, A. M. B., et al. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12022 · Cited by 39
Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity
Smith, T. F., Anastopoulos, A. D., Garrett, M. E., Vásquez, A. A., Franke, B., Oades, R. D., Sonuga-Barke, E. J. S., Asherson, P. J., Gill, M., Buitelaar, J. K., et al. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32275 · Cited by 40
Attention and Impulsivity
Nigg, J. T. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy314 · Cited by 41
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 40
Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype
Li, J. J., & Lee, S. S. (2011) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-011-9553-z · Cited by 41
Multilevel analysis of ADHD, anxiety and depression symptoms aggregation in families
Segenreich, D., Paez, M. S., Regalla, M. A., Fortes, D., Faraone, S. V., Sergeant, J. A., & Mattos, P. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0604-1 · Cited by 37
Blood lead, parental marital status and the risk of attention-deficit/hyperactivity disorder in elementary school children: A longitudinal study
Choi, W., Kwon, H., Lim, M. H., Lim, J.-A., & Ha, M. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.002 · Cited by 39
ADHD-like symptoms and attachment in internationally adopted children
Jaume, N. A., Barcons, N., Marre, D., Gasca, C. B. I., Fornieles-Deu, A., & Fumadó, V. (2012) · Attachment & Human Development · doi:10.1080/14616734.2012.691656 · Cited by 43
Inflammation, Dopaminergic Brain and Bilirubin
Jayanti, S. D., Verde, C. D., Tiribelli, C., & Gazzin, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411478 · Cited by 39
Developmental disabilities across the world: A scientometric review from 1936 to 2020
Carollo, A., Bonassi, A., Lim, M., Gabrieli, G., Setoh, P., Dimitriou, D., Aryadoust, V., & Esposito, G. (2021) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2021.104031 · Cited by 35
Children diagnosed with attention deficit disorder and their hospitalisations: population data linkage study
Silva, D. T., Colvin, L., Hagemann, E., Stanley, F. J., & Bower, C. I. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0545-8 · Cited by 35
Methylphenidate effects in the young brain: friend or foe?
Loureiro‐Vieira, S., Costa, V. M., Bastos, M. D. L., Carvalho, F. D., & Capela, J. P. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.04.002 · Cited by 38
Diversity in Pathways to Common Childhood Disruptive Behavior Disorders
Martel, M. M., Nikolas, M. A., Jernigan, K. A., Friderici, K. H., & Nigg, J. T. (2012) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-012-9646-3 · Cited by 34
Maternal Depression History Moderates Parenting Responses to Compliant and Noncompliant Behaviors of Children with ADHD
Thomas, S. R., O’Brien, K., Clarke, T. L., Liu, Y., & Chronis-Tuscano, A. M. (2014) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-014-9957-7 · Cited by 32
Disentangling the effects of video pace and story realism on children’s attention and response inhibition
Kostyrka‐Allchorne, K., Cooper, N. R., & Simpson, A. (2019) · Cognitive Development · doi:10.1016/j.cogdev.2018.12.003 · Cited by 36
Prevalence of probable Attention-Deficit/Hyperactivity Disorder symptoms: result from a Spanish sample of children
Cerrillo-Urbina, A. J., García‐Hermoso, A., Martínez‐Vizcaíno, V., Pardo‐Guijarro, M. J., Hermosa, A. R., & Sánchez‐López, M. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-1083-1 · Cited by 32
The Cambridge Handbook of Infant Development
Lockman, J. J., Hertz, D., Tamis-LeMonda, C. S., Brain, B. C., Context..........................................., Rey, J., Falck-Ytter, T., Jones, E., Maurer, D., Cirelli, L., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108351959 · Cited by 31
Pre- and Perinatal Risk for Attention-Deficit Hyperactivity Disorder: Does Neuropsychological Weakness Explain the Link?
Wiggs, K. K., Elmore, A. L., Nigg, J. T., & Nikolas, M. A. (2016) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-016-0142-z · Cited by 31
Neighborhood Socioeconomic Characteristics and Utilization of ADHD Medication in Schoolchildren: A Population Multilevel Study in Stockholm County
Jablonska, B., Kosidou, K., de León, A. P., Wettermark, B., Magnusson, C., Dal, H., & Dalman, C. (2016) · Journal of Attention Disorders · doi:10.1177/1087054716643257 · Cited by 31
Neighborhood Characteristics and ADHD
Razani, N., Hilton, J. F., Halpern‐Felsher, B. L., Okumura, M. J., Morrell, H. E. R., & Yen, I. H. (2014) · Journal of Attention Disorders · doi:10.1177/1087054714542002 · Cited by 27
Prenatal and Postnatal Predictive Factors for Children’s Inattentive and Hyperactive Symptoms at 5 Years of Age: The Role of Early Family-related Factors
Huhdanpää, H., Morales‐Muñoz, I., Aronen, E. T., Pölkki, P., Saarenpää‐Heikkilä, O., Kylliäinen, A., & Paavonen, E. J. (2020) · Child Psychiatry & Human Development · doi:10.1007/s10578-020-01057-7 · Cited by 26
Role of Omega-3 PUFAs in Neurobiological Health
Grant, R., & Guest, J. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_13 · Cited by 28
Prenatal Maternal Smoking and Tourette Syndrome: A Nationwide Register Study
Leivonen, S., Chudal, R., Joelsson, P., Ekblad, M. O., Suominen, A., Brown, A. S., Gissler, M., Voutilainen, A., & Sourander, A. (2015) · Child Psychiatry & Human Development · doi:10.1007/s10578-015-0545-z · Cited by 25
The Development of Multisensory Attention Skills
Bahrick, L. E., Lickliter, R., & Todd, J. T. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108351959.011 · Cited by 27
Prematurity and ADHD in Childhood: An Observational Register-Based Study in Catalonia
Perapoch, J., Vidal, R., Gómez-Lumbreras, A., Hermosilla, E., Riera, L. B., Cortés, J., Céspedes, M. C., Ramos‐Quiroga, J. A., & Morros, R. (2019) · Journal of Attention Disorders · doi:10.1177/1087054719864631 · Cited by 29
Parental Involvement Moderates Etiological Influences on Attention Deficit Hyperactivity Disorder Behaviors in Child Twins
Nikolas, M. A., Klump, K. L., & Burt, S. A. (2014) · Child Development · doi:10.1111/cdev.12296 · Cited by 26
Prenatal Tobacco Exposure Modulated the Association of Genetic variants with Diagnosed ADHD and its symptom domain in children: A Community Based Case–Control Study
Wang, Y., Hu, D., Chen, W., Xue, H.-L., & Du, Y.-K. (2019) · Scientific Reports · doi:10.1038/s41598-019-40850-w · Cited by 22
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study
Leivonen, S., Scharf, J. M., Mathews, C. A., Chudal, R., Gyllenberg, D., Sucksdorff, D., Suominen, A., Voutilainen, A., Brown, A. S., & Sourander, A. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.01.009 · Cited by 25
Prediction of sleep side effects following methylphenidate treatment in ADHD youth
Yoo, J. H., Sharma, V., Kim, J. W., McMakin, D. L., Hong, S.-B., Zalesky, A., Kim, B.-N., & Ryan, N. D. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102030 · Cited by 23
Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g
Rahman, M. S., Takahashi, N., Iwabuchi, T., Nishimura, T., Harada, T., Okumura, A., Takei, N., Nomura, Y., & Tsuchiya, K. J. (2021) · BMC Medicine · doi:10.1186/s12916-021-02093-3 · Cited by 23
Maternal Thyroid Function in Early Pregnancy and Child Attention-Deficit Hyperactivity Disorder: An Individual-Participant Meta-Analysis
Levie, D., Korevaar, T. I. M., Mulder, T. A., Bath, S. C., Dineva, M., López-Espinosa, M.-J., Basterrechea, M., Santa‐Marina, L., Rebagliato, M., Sunyer, J., et al. (2019) · Thyroid · doi:10.1089/thy.2018.0794 · Cited by 22
Low hair cortisol concentration and emerging attention‐deficit/hyperactivity symptoms in preschool age
Schloß, S., Ruhl, I., Müller, V., Becker, K., Skoluda, N., Nater, U. M., & Pauli‐Pott, U. (2018) · Developmental Psychobiology · doi:10.1002/dev.21627 · Cited by 21
Exposure to environmental pollutants and attention-deficit/hyperactivity disorder: an overview of systematic reviews and meta-analyses
Rosi, E., Crippa, A., Pozzi, M., Francesco, S. D., Fioravanti, M., Mauri, M., Molteni, M., Morello, L., Tosti, L., Metruccio, F., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30173-9 · Cited by 23
The dopamine receptor D4 gene and familial loading interact with perceived parenting in predicting externalizing behavior problems in early adolescence: The TRacking Adolescents' Individual Lives Survey (TRAILS)
Marsman, R., Oldehinkel, A. J., Ormel, J., & Buitelaar, J. K. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.10.022 · Cited by 23
Late-Preterm Birth by Delivery Circumstance and Its Association With Parent-Reported Attention Problems in Childhood
Talge, N. M., Holzman, C., Egeren, L. A. V., Symonds, L. L., Scheid, J. M., Senagore, P. K., & Sikorskii, A. E. (2012) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3182564704 · Cited by 21
Sex moderates the impact of birth weight on child externalizing psychopathology.
Momany, A. M., Kamradt, J. M., Ullsperger, J. M., Elmore, A. L., Nigg, J. T., & Nikolas, M. A. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000238 · Cited by 19
A Gene-Environment Interaction Study of Polygenic Scores and Maltreatment on Childhood ADHD
He, Q., & Li, J. J. (2021) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-021-00873-2 · Cited by 23
Neuropsychological performance measures as intermediate phenotypes for attention-deficit/hyperactivity disorder: a multiple mediation analysis
Kamradt, J. M., Nigg, J. T., Friderici, K. H., & Nikolas, M. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579416000195 · Cited by 19
Psychosocial risk factors underlie the link between attention deficit hyperactivity symptoms and overweight at school entry
Pauli-Pott, U., Reinhardt, A., Bagus, E., Wollenberg, B., Schroer, A., Heinzel-Gutenbrunner, M., & Becker, K. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0870-1 · Cited by 18
Does 5HTTLPR Genotype Moderate the Association of Family Environment With Child Attention-Deficit Hyperactivity Disorder Symptomatology?
Elmore, A. L., Nigg, J. T., Friderici, K. H., Jernigan, K. A., & Nikolas, M. A. (2015) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2014.979935 · Cited by 19

Authors: Nigg, J., Nikolas, M., & Burt, S. A.
Affiliations: Oregon Health & Science University (US)
Michigan State University (US)
Corresponding author: Nigg, Joel
ORCID: Nigg, Joel
Nikolas, Molly
Burt, S. Alexandra
Venue: Journal of the American Academy of Child & Adolescent Psychiatry
Publisher: Elsevier BV
Published: 2010-09
Volume: 49
Issue: 9
Pages: 863-873
ISSN: 0890-8567 (ISSN-L)
DOI: 10.1016/j.jaac.2010.01.025
PMC: PMC2928573
OpenAlex: W2153600210
Cited by: 259
References: 60
Citations by year: 2026: 2 · 2025: 5 · 2024: 8 · 2023: 15 · 2022: 5 · 2021: 21 · 2020: 56 · 2019: 21 · 2018: 9 · 2017: 17 · 2016: 19 · 2015: 14 · 2014: 20 · 2013: 14 · 2012: 20
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01 MH-59105, R01MH059105)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: gene-environment interaction, attention deficit hyperactivity disorder, psychosocial risk factors, genetic susceptibility, ADHD etiology, candidate gene markers
MeSH terms: Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Chromosome Mapping, Female, Genetic Markers, Genotype, Humans, Life Change Events, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Social Environment, Parenting, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measured Gene-by-Environment Interaction in Relation to Attention-Deficit/Hyperactivity Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks