“But it might be a heart attack”: Intolerance of uncertainty and panic disorder symptoms
Open accessAbstract
Panic disorder models describe interactions between feared anxiety-related physical sensations (i.e., anxiety sensitivity; AS) and catastrophic interpretations therein. Intolerance of uncertainty (IU) has been implicated as necessary for catastrophic interpretations in community samples. The current study examined relationships between IU, AS, and panic disorder symptoms in a clinical sample. Participants had a principal diagnosis of panic disorder, with or without agoraphobia (n=132; 66% women). IU was expected to account for significant variance in panic symptoms controlling for AS. AS was expected to mediate the relationship between IU and panic symptoms, whereas IU was expected to moderate the relationship between AS and panic symptoms. Hierarchical linear regressions indicated that IU accounted for significant unique variance in panic symptoms relative to AS, with comparable part correlations. Mediation and moderation models were also tested and suggested direct and indirect effects of IU on panic symptoms through AS; however, an interaction effect was not supported. The current cross-sectional evidence supports a role for IU in panic symptoms, independent of AS.
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Carleton et al. reported that IU and anxiety sensitivity are independent vulnerabilities for panic disorder, and intervention may benefit from addressing both IU and anxiety sensitivity.
“Carleton et al.13 reported that IU and AS are independent vulnerabilities for panic disorder, and intervention may benefit from addressing both IU and AS.”
From Impact of mindfulness-based cognitive therapy on intolerance of uncertainty in patients with panic disorder (2016) · cites this paper as [13]
In patients with panic disorder, there was a significant relationship between the IU inhibitory dimension and anxiety sensitivity somatic and cognitive dimensions with panic symptom severity.
“Similarly, in patients with panic disorder, there was a significant relationship between the IU inhibitory dimension and anxiety sensitivity (AS) somatic and cognitive dimensions with panic symptom severity.13”
From Impact of mindfulness-based cognitive therapy on intolerance of uncertainty in patients with panic disorder (2016) · cites this paper as [13]
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- Authors
- Carleton, R. N., Duranceau, S., Freeston, M. H., Boelen, P. A., McCabe, R. E., & Antony, M. M.
- Affiliations
- University of Regina (CA)
- Newcastle University (GB)
- Utrecht University (NL)
- St. Joseph’s Healthcare Hamilton (CA)
- Toronto Metropolitan University (CA)
- Corresponding author
- Carleton, R. Nicholas
- Venue
- Journal of Anxiety Disorders
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 28
- Issue
- 5
- Pages
- 463-470
- ISSN
- 0887-6185 (ISSN-L)
- OpenAlex
- W2115391578
- Cited by
- 118
- References
- 94
- Citations by year
- 2025: 8 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 8 · 2020: 15 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 20 · 2015: 7
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Anxiety Disorders (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- intolerance of uncertainty, panic disorder, anxiety sensitivity, panic symptoms, panic disorder with agoraphobia, mediation, moderation, bodily sensations
- MeSH terms
- Adult, Agoraphobia, Anxiety, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Panic Disorder, Uncertainty
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