Bone marrow and peripheral white blood cells number is affected by sleep deprivation in a murine experimental model
Abstract
Sleep deficit and related disorders are becoming increasingly prevalent in modern life and an extensive literature has documented that acute or chronic sleep deprivation can lead to several physiological consequences. Here, we evaluated the effects of sleep deprivation on hematopoietic composition of either bone marrow or peripheral blood. Mice were subjected to paradoxical sleep deprivation (PSD) for 72 h by modified multiple platform method, with or without an additional sleep recovery (SR) period of 10 days. PSD decreased total cellularity of the bone marrow and peripheral blood concomitantly. Subsequent analysis of cell composition showed that absolute number of hematopoietic stem/progenitor cells and colony‐forming units was decreased. Moreover, the absolute number of granulocytes and monocytes in bone marrow was reduced in PSD group. These alterations were paralleled by an accumulation of neutrophils and monocytes in peripheral blood. PSD also induced lymphopenia in the circulation. To the best of our knowledge, this is the first study that demonstrates the importance of sleep on the hematopoietic microenvironment and provides new insights into the relationship between sleep and the immune system. J. Cell. Physiol. 227: 361–366, 2012. © 2011 Wiley Periodicals, Inc.
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In patients with Epstein Barr virus-linked infectious mononucleosis, self-reported sleep duration was markedly increased and debilitating daytime sleepiness persisted over many years.
“In patients with an infectious illness linked to the Epstein Barr virus (EBV), such as infectious mononucleosis, self-reported sleep duration was markedly increased (349) and debilitating daytime sleepiness persisted over many years (218).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [218]
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Self-citation
- Authors
- Guariniello, L. D., Vicari, P., Lee, K. S., de Oliveira, A. C., & Tufik, S.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Associação Fundo de Incentivo à Pesquisa (BR)
- Corresponding author
- Guariniello, Luciana Doria
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2011-10-24
- Volume
- 227
- Issue
- 1
- Pages
- 361-366
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2069388466
- Cited by
- 30
- References
- 44
- Citations by year
- 2024: 5 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Associação Fundo de Incentivo à Pesquisa
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, REM sleep deprivation, bone marrow, hematopoietic stem and progenitor cells, colony-forming units, granulocytes, monocytes, neutrophils, lymphopenia, sleep recovery, hematopoietic microenvironment, mice
- MeSH terms
- Animals, Bone Marrow Cells, Cell Separation, Disease Models, Animal, Flow Cytometry, Hematopoietic Stem Cells, Leukocyte Count, Leukocytes, Male, Mice, Inbred C57BL, Sleep Deprivation, Mice
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