Anxiety sensitivity: Prospective prediction of panic attacks and Axis I pathology
Abstract
Emerging evidence suggests that anxiety sensitivity (AS) predicts subsequent development of anxiety symptoms and panic attacks. However, evidence regarding whether AS serves as a premorbid risk factor for the development of clinical syndromes is lacking. The primary aim of the present study was to determine whether AS acts as a vulnerability factor in the pathogenesis of psychiatric diagnoses. A large nonclinical sample of young adults (N=404) was prospectively followed over two years. The Anxiety Sensitivity Index (ASI: Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency, and the prediction of fearfulness. Behaviour Research and Therapy 1986; 24: 1-8.) and trait anxiety served as predictors. Consistent with prior reports, AS predicted the development of spontaneous panic attacks in those with no history of panic. Importantly, AS was found to predict the incidence of anxiety disorder diagnoses and overall Axis I diagnoses in those with no history of Axis I diagnoses at study entry. These are the first data to provide strong prospective evidence for AS as a risk factor in the development of anxiety disorders.
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Anxiety sensitivity is related to depressive symptoms and disorders, albeit to a lesser extent than to anxiety symptoms and psychopathology.
“Moreover, anxiety sensitivity is related to depressive symptoms and disorders ( Cox, Borger, & Enns, 1999 ;Otto, Pollack, Fava, Uccello, & Rosenbaum, 1995 ;Schmidt et al., 2006 ), albeit to a lesser extent than to anxiety symptoms and psychopathology ( Schmidt, Lerew, & Joiner, 1998 ).”
From Anxiety sensitivity and anxiety and depressive symptoms in the prediction of early smoking lapse and relapse during smoking cessation treatment (2009) · cites this paper as Schmidt et al., 2006
Anxiety sensitivity is related to increased risk for anxiety symptoms and disorders.
“Given that anxiety sensitivity is related to increased risk for anxiety symptoms and disorders ( Hayward et al., 2000 ;Schmidt et al., 2006 )”
From Anxiety sensitivity and anxiety and depressive symptoms in the prediction of early smoking lapse and relapse during smoking cessation treatment (2009) · cites this paper as Schmidt et al., 2006
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An anxiety sensitivity reduction smoking-cessation program for Spanish-speaking smokers (Argentina)
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Self-citationPanic Disorder and Agoraphobia
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Integration of interoceptive exposure in eating disorder treatment.
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Coping through avoidance may explain gender disparities in anxiety
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Anxiety sensitivity risk reduction in smokers: A randomized control trial examining effects on panic
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Refinement of anxiety sensitivity measurement: the short scale anxiety sensitivity index (SSASI)
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Self-citationExamining the short-term anxiolytic and antidepressant effect of Floatation-REST
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Etiology of the dimensions of anxiety sensitivity: A behavioral–genetic analysis
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Anxiety sensitivity, its stability and longitudinal association with severity of anxiety symptoms
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Medical information seeking: Impact on risk for anxiety psychopathology
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Self-citationÜberprüfung der psychometrischen Qualität der deutschen Version des Angstsensitivitätsindex-3
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Anxiety sensitivity and marijuana use: an analysis from ecological momentary assessment
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Serotonin transporter gene and childhood trauma - a G × E effect on anxiety sensitivity
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Is anxiety sensitivity a predictor of PTSD in children and adolescents?
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Trends in Psychiatry and Psychotherapy
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The interaction of early life experiences with COMT val158met affects anxiety sensitivity
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A Bifactor Model of Anxiety Sensitivity: Analysis of the Anxiety Sensitivity Index-3
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Suicidality and Anxiety Sensitivity in Adults with HIV
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Anxiety Sensitivity Prospectively Predicts Posttraumatic Stress Symptoms Following a Campus Shooting
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Altered top-down and bottom-up processing of fear conditioning in panic disorder with agoraphobia
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Ataque de nervios: relationship to anxiety sensitivity and dissociation predisposition
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The effects of exercise on transdiagnostic treatment targets: A meta-analytic review
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Anxiety sensitivity: selective review of promising research and future directions
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The genetics of panic disorder
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- Authors
- Schmidt, N. B., Zvolensky, M. J., & Maner, J. K.
- Affiliations
- Florida State University (US)
- University of Vermont (US)
- Corresponding author
- Schmidt, Norman B.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 40
- Issue
- 8
- Pages
- 691-699
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2061810459
- Cited by
- 485
- References
- 68
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 22 · 2020: 17 · 2019: 15 · 2018: 35 · 2017: 28 · 2016: 32 · 2015: 41 · 2014: 40 · 2013: 32 · 2012: 36
- FWCI
- 35.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21da016227-02, 5r01da018734-03, 1r03mh072848-01a1)
- National Institute of Mental Health (MH62056, MH72848, R21MH062056)
- National Institute on Drug Abuse (1R21 DA 016227-01, 1R01 DA 018734-01A1)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anxiety sensitivity, panic attacks, anxiety disorders, Axis I diagnoses, premorbid risk factors, vulnerability factors, trait anxiety, Anxiety Sensitivity Index, young adults, prospective prediction
- MeSH terms
- Adult, Anxiety, Female, Humans, Interview, Psychological, Male, Predictive Value of Tests, Prospective Studies, Risk Factors, Sensitivity and Specificity, Incidence, Panic Disorder
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