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Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
Open accessAbstract
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion of AcCoA. AcCoA depletion entailed the commensurate reduction in the overall acetylation of cytoplasmic proteins, as well as the induction of autophagy, a homeostatic process of self-digestion. Multiple distinct manipulations designed to increase or reduce cytosolic AcCoA led to the suppression or induction of autophagy, respectively, both in cultured human cells and in mice. Moreover, maintenance of high AcCoA levels inhibited maladaptive autophagy in a model of cardiac pressure overload. Depletion of AcCoA reduced the activity of the acetyltransferase EP300, and EP300 was required for the suppression of autophagy by high AcCoA levels. Altogether, our results indicate that cytosolic AcCoA functions as a central metabolic regulator of autophagy, thus delineating AcCoA-centered pharmacological strategies that allow for the therapeutic manipulation of autophagy.
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“In fact, acetyl-CoA controls longevity and autophagy in a panel of model systems (Eisenberg et al., 2014; Mariño et al., 2014): This energy metabolite integrates various nutrition pathways and is the only known donor in acetylation reactions.”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Mariño et al., 2014
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Self-citationAutophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Self-citationTFEB Links Autophagy to Lysosomal Biogenesis
Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105
Induction of autophagy by spermidine promotes longevity
Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680
Network organization of the human autophagy system
Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationAcetyl coenzyme A: a central metabolite and second messenger
Pietrocola, F., Galluzzi, L., Bravo-San Pedro, J. M., Madeo, F., & Kroemer, G. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.014 · Cited by 1,378
Mitochondrial metabolism and cancer
Porporato, P. E., Filigheddu, N., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2017) · Cell Research · doi:10.1038/cr.2017.155 · Cited by 1,323
Spermidine in health and disease
Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154
Self-citationModulation of cellular processes by histone and non-histone protein acetylation
Shvedunova, M., & Akhtar, A. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00441-y · Cited by 1,007
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
Shi, L., & Tu, B. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.003 · Cited by 903
“In mammalian cells, autophagy regulation by acetyl-CoA occurs in a manner dependent on the p300 acetyltransferase [20].”
BackgroundQuirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860
Metabolic control of autophagy
Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
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Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630
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Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592
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Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.016 · Cited by 542
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Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563
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The Role of Autophagy in the Heart
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Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514
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Self-citationAkt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Covarrubias, A. J., Aksoylar, H., Yu, J., Snyder, N. W., Worth, A. J., Iyer, S. S., Wang, J., Ben‐Sahra, I., Byles, V., Polynne-Stapornkul, T., et al. (2016) · eLife · doi:10.7554/elife.11612 · Cited by 469
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He, A., Chen, X., Tan, M., Chen, Y., Lu, D., Zhang, X., Dean, J. M., Razani, B., & Lodhi, I. J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.007 · Cited by 243
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Sun, T., Li, X., Zhang, P., Chen, W.-D., Zhang, H., Li, D., Deng, R., Qian, X.-J., Jiao, L., Ji, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8215 · Cited by 246
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Schiattarella, G. G., & Hill, J. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.019 · Cited by 178
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Wan, W., You, Z., Xu, Y., Zhou, L., Guan, Z., Peng, C., Wong, C. C. L., Su, H., Zhou, T., Xia, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.020 · Cited by 178
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Yi, X., Guo, W., Shi, Q., Yang, Y., Zhang, W., Chen, X., Kang, P., Chen, J., Cui, T., Ma, J., et al. (2019) · Theranostics · doi:10.7150/thno.30398 · Cited by 167
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Cheng, C.-T., Qi, Y., Wang, Y.-C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y.-R., Oh, M. E., Sheng, X., Tang, Y., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0178-4 · Cited by 164
Su, H., Yang, F., Wang, Q., Shen, Q., Huang, J., Peng, C., Zhang, Y., Wan, W., Wong, C. C. L., Sun, Q., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.024 · Cited by 164
Regulation of autophagy by protein post-translational modification
Wani, W. Y., Boyer‐Guittaut, M., Dodson, M. B., Chatham, J. C., Darley-Usmar, V. M., & Zhang, J. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.131 · Cited by 160
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Orogo, A. M., & Gustafsson, Å. B. (2015) · Circulation Research · doi:10.1161/circresaha.116.303791 · Cited by 157
Glutaminolysis and autophagy in cancer
Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143
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Lee, I. H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0302-7 · Cited by 151
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation
Shen, Q., Shi, Y. P., Liu, J., Su, H., Huang, J., Zhang, Y., Peng, C., Zhou, T., Sun, Q., Wan, W., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1752471 · Cited by 142
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila
Peleg, S., Feller, C., Forné, I., Schiller, E., Sévin, D. C., Schauer, T., Regnard, C., Straub, T., Prestel, M., Klima, C., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541132 · Cited by 136
Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism
Ye, C., & Tu, B. P. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.06.002 · Cited by 142
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis
Li, M., Chiang, Y., Lyssiotis, C. A., Teater, M. R., Hong, J. Y., Shen, H., Wang, L., Hu, J., Jing, H., Chen, Z., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.002 · Cited by 143
Autophagy and Non-Alcoholic Fatty Liver Disease
Lavallard, V., & Gual, P. (2014) · BioMed Research International · doi:10.1155/2014/120179 · Cited by 138
Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view
Pagliassotti, M. J., Kim, P., Estrada, A. L., Stewart, C. M., & Gentile, C. L. (2016) · Metabolism · doi:10.1016/j.metabol.2016.05.002 · Cited by 137
Arber, C., Li, A., Houlden, H., & Wray, S. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12242 · Cited by 139
Gohir, W., Kennedy, K. M., Wallace, J. G., Saoi, M., Bellissimo, C. J., Britz‐McKibbin, P., Petrik, J., Surette, M. G., & Sloboda, D. M. (2019) · The Journal of Physiology · doi:10.1113/jp277353 · Cited by 133
Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis
Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A. A., Podgoršek, A., Kosec, G., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1906 · Cited by 127
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Pedro, J. M. B., Sica, V., Martins, I., Pol, J. G., Loos, F., Maiuri, M. C., Durand, S., Bossut, N., Aprahamian, F., Anagnostopoulos, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.010 · Cited by 127
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Czumaj, A., Szrok-Jurga, S., Hebanowska, A., Turyn, J., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239057 · Cited by 128
Metadata
- Authors
- Mariño, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., Zamzami, N., Scoazec, M., Durand, S., Enot, D. P., Fernández, Á. F., Martins, I., Kepp, O., Senovilla, L., Bauvy, C., Morselli, E., Vacchelli, E., Bennetzen, M., Magnes, C., Sinner, F., Pieber, T., López-Otín, C., Maiuri, M. C., Codogno, P., Andersen, J. S., Hill, J. A., Madeo, F., & Kroemer, G.
- Affiliations
- Inserm (FR)
- University of Graz (AT)
- The University of Texas Southwestern Medical Center (US)
- Joanneum Research (AT)
- Universidad de Oviedo (ES)
- University of Southern Denmark (DK)
- Corresponding author
- Madeo, Frank
- Kroemer, Guido
- ORCID
- Mariño, Guillermo
- Pietrocola, Federico
- Eisenberg, Tobias
- Malik, Shoaib Ahmad
- Pendl, Tobias
- Fernández, Álvaro F.
- Martins, Isabelle
- Kepp, Oliver
- Senovilla, Laura
- Morselli, Eugenia
- Vacchelli, Erika
- Magnes, Christoph
- Sinner, Frank
- Pieber, Thomas
- Maiuri, Maria Chiara
- Codogno, Patrice
- Andersen, Jens S.
- Hill, Joseph A.
- Madeo, Frank
- Kroemer, Guido
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 53
- Issue
- 5
- Pages
- 710-725
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2095000965
- Cited by
- 500
- References
- 53
- Citations by year
- 2026: 19 · 2025: 28 · 2024: 33 · 2023: 32 · 2022: 41 · 2021: 52 · 2020: 51 · 2019: 54 · 2018: 50 · 2017: 34 · 2016: 39 · 2015: 39 · 2014: 28
- FWCI
- 35.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository University of Extremadura (University of Extremadura) (submittedVersion, other-oa)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-PHUC-0002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- acetyl-CoA, autophagy regulation, protein acetylation, nutrient deprivation, EP300, acetyltransferase, cardiac pressure overload, metabolic regulation, autophagy induction, autophagy inhibition
- MeSH terms
- Acetyl Coenzyme A, Adenosine Triphosphate, Animals, Autophagy, Cell Nucleus, Cytoplasm, Cytosol, HeLa Cells, Humans, Ketoglutaric Acids, Mice, Inbred C57BL, Microscopy, Fluorescence, Mitochondria, Gene Expression Regulation, Enzymologic, RNA, Small Interfering, HCT116 Cells, Cell Line, Tumor, Green Fluorescent Proteins, E1A-Associated p300 Protein, Mice
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