Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease
Open accessAbstract
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin (HTT) gene, which is expressed ubiquitously throughout the brain and peripheral tissues. Whilst the focus of much research has been on the cognitive, psychiatric and motor symptoms of HD, the extent of peripheral pathology and its potential impact on central symptoms has been less intensely explored. Disruption of the gastrointestinal microbiome (gut dysbiosis) has been recently reported in a number of neurological and psychiatric disorders, and therefore we hypothesized that it might also occur in HD. We have used 16S rRNA amplicon sequencing to characterize the gut microbiome in the R6/1 transgenic mouse model of HD, relative to littermate wild-type controls. We report that there is a significant difference in microbiota composition in HD mice at 12 weeks of age. Specifically, we observed an increase in Bacteriodetes and a proportional decrease in Firmicutes in the HD gut microbiome. In addition, we observed an increase in microbial diversity in male HD mice, compared to wild-type controls, but no differences in diversity were observed in female HD mice. The gut dysbiosis observed coincided with impairment in body weight gain despite higher food intake as well as motor deficits at 12 weeks of age. Gut dysbiosis was also associated with a change in the gut microenvironment, as we observed higher fecal water content in HD mice at 12 weeks of age. This study provides the first evidence of gut dysbiosis in HD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A higher relative abundance of Bacteroidetes and a lower relative abundance of Firmicutes are reported in both R6/1 and R6/2 mice compared with wild-type mice.
“Moreover, a higher relative abundance of Bacteroidetes and a lower relative abundance of Firmicutes were reported in both R6/1 and R6/2 mice, as compared to WT mice.235,236”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [235]
The HDGEC study did not observe an increase in Bacteroidetes and a reduction in Firmicutes as reported in R6/1 and R6/2 mice.
“However, the study did not observe an increase in Bacteroidetes and a reduction in Firmicutes, as reported in both R6/1 and R6/2 mice.235,236”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [235]
A notable difference in gut microbiota composition is observed between R6/1 mice and wild-type mice at 12 weeks of age, coinciding with motor deficits and weight loss.
“A notable difference in gut microbiota composition was observed between R6/1 mice and wild-type (WT) mice at 12 weeks of age (early disease stage), which coincided with the manifestation of motor deficits and weight loss.235”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [235]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
DADA2: High–resolution sample inference from Illumina amplicon data
Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894 · see citing works
A new method for non-parametric multivariate analysis of variance
Anderson, M. J. (2001) · Austral Ecology · doi:10.1111/j.1442-9993.2001.01070.pp.x · Cited by 13,828 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
VEGAN, a package of R functions for community ecology
Dixon, P. M. (2003) · Journal of Vegetation Science · doi:10.1111/j.1654-1103.2003.tb02228.x · Cited by 6,783 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Self-citationBiogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
mixOmics: An R package for ‘omics feature selection and multiple data integration
Rohart, F., Gautier, B., Singh, A., & Lê Cao, K.-A. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005752 · Cited by 4,056 · see citing works
Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease
Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Gut microbiota are related to Parkinson's disease and clinical phenotype
Scheperjans, F., Aho, V., Pereira, P. A. B., Koskinen, K., Paulin, L., Pekkonen, E., Haapaniemi, E., Kaakkola, S., Eerola‐Rautio, J., Pohja, M., et al. (2015) · Movement Disorders · doi:10.1002/mds.26069 · Cited by 1,968 · see citing works
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works
Vandeputte, D., Falony, G., Vieira-Silva, S., Tito, R. Y., Joossens, M., & Raes, J. (2016) · Gut · doi:10.1136/gutjnl-2015-309618 · Cited by 1,028 · see citing works
Greenblum, S., Turnbaugh, P. J., & Borenstein, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116053109 · Cited by 821 · see citing works
The host shapes the gut microbiota via fecal microRNA
Liu, S., da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., Comstock, L. E., Gandhi, R., & Weiner, H. L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2015.12.005 · Cited by 808 · see citing works
Sex differences and hormonal effects on gut microbiota composition in mice
Org, E., Mehrabian, M., Parks, B. W., Shipkova, P., Liu, X., Drake, T. A., & Lusis, A. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1203502 · Cited by 796 · see citing works
Intestinal epithelial cells secrete exosome–like vesicles
van Niel, G., Raposo, G., Candalh, C., Boussac, M., Hershberg, R. M., Cerf–Bensussan, N., & Heyman, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.26263 · Cited by 698 · see citing works
Packer, A. N., Xing, Y., Harper, S. Q., Jones, L., & Davidson, B. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2390-08.2008 · Cited by 679 · see citing works
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671 · see citing works
Sex differences in cognitive impairment and Alzheimer’s disease
Li, R., & Singh, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.01.002 · Cited by 527 · see citing works
Widespread expression of Huntington's disease gene (IT15) protein product
Sharp, A. H., Loev, S. J., Schilling, G., Li, S.-H., Li, X.-J., Bao, J., Wagster, M. V., Kotzuk, J. A., Steiner, J. P., Lo, A., et al. (1995) · Neuron · doi:10.1016/0896-6273(95)90345-3 · Cited by 513 · see citing works
Self-citationAdult hippocampal neurogenesis is regulated by the microbiome
Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F., & O’Leary, O. F. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.023 · Cited by 491 · see citing works
Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
Roager, H. M., Hansen, L. B. S., Bahl, M. I., Frandsen, H. L., Carvalho, V., Gøbel, R. J., Dalgaard, M. D., Plichta, D. R., Sparholt, M. H., Vestergaard, H., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.93 · Cited by 449 · see citing works
Energy metabolism defects in Huntington's disease and effects of coenzyme Q<sub>10</sub>
Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405 · see citing works
New-found link between microbiota and obesity
Chakraborti, C. K. (2015) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v6.i4.110 · Cited by 378 · see citing works
Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364 · see citing works
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
Kim, J., Moody, J. P., Edgerly, C. K., Bordiuk, O. L., Cormier, K., Smith, K., Beal, M. F., & Ferrante, R. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq306 · Cited by 356 · see citing works
Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., & Hanson, M. R. (2016) · Microbiome · doi:10.1186/s40168-016-0171-4 · Cited by 339 · see citing works
Beal, M. F., Matson, W. R., Swartz, K. J., Gamache, P. H., & Bird, E. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb03143.x · Cited by 312 · see citing works
Altered microRNA regulation in Huntington's disease models
Lee, S., Chu, K., Im, W., Yoon, H., Im, J.-Y., Park, J.-E., Park, K.-H., Jung, K., Lee, S. K., Kim, M., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.012 · Cited by 289 · see citing works
Formation of Polyglutamine Inclusions in Non-CNS Tissue
Sathasivam, K., Hobbs, C., Turmaine, M., Mangiarini, L., Mahal, A., Bertaux, F., Wanker, E. E., Doherty, P., Davies, S. W., & Bates, G. P. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.813 · Cited by 286 · see citing works
Stilling, R. M., Ryan, F. J., Hoban, A. E., Shanahan, F., Clarke, G., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.009 · Cited by 233 · see citing works
The microbiome regulates amygdala-dependent fear recall
Hoban, A. E., Stilling, R. M., Moloney, G., Shanahan, F., Dinan, T. G., Clarke, G., & Cryan, J. F. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.100 · Cited by 197 · see citing works
MixMC: A Multivariate Statistical Framework to Gain Insight into Microbial Communities
Cao, K. L., Costello, M., Lakis, V., Bartolo, F., Chua, X., Brazeilles, R., & Rondeau, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160169 · Cited by 178 · see citing works
Self-citationMoffitt, H., McPhail, G., Woodman, B., Hobbs, C., & Bates, G. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008025 · Cited by 151 · see citing works
Hoss, A. G., Labadorf, A., Latourelle, J. C., Kartha, V. K., Hadzi, T. C., Gusella, J. F., MacDonald, M. E., Chen, J.-F., Akbarian, S., Weng, Z., et al. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0083-3 · Cited by 151 · see citing works
Oliveira, J. M. A., Jekabsons, M. B., Chen, S., Lin, A., Rego, A. C., Gonçalves, J., Ellerby, L., & Nicholls, D. G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04361.x · Cited by 136 · see citing works
Sex dimorphism profile of Alzheimer’s disease-type pathologies in an APP/PS1 mouse model
Jiao, S.-S., Bu, X.-L., Liu, Y.-H., Zhu, C., Wang, Q.-H., Shen, L.-L., Liu, C.-H., Wang, Y.-R., Yao, X.-Q., & Wang, Y.-J. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9589-x · Cited by 129 · see citing works
Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice
van der Burg, J. M. M., Winqvist, A., Aziz, N. A., Maat–Schieman, M. L. C., Roos, R. A. C., Bates, G. P., Brundin, P., Björkqvist, M., & Wierup, N. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.006 · Cited by 111 · see citing works
Péronnet, F., Mignault, D., du Souich, P., Vergne, S., Bellego, L. L., Jiménez, L., & RABASA-LHORET, R. P. R. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2194-7 · Cited by 95 · see citing works
Verwaest, K. A., Vu, T. N., Laukens, K., Clemens, L. E., Nguyen, H. P., Gasse, B. V., Martins, J. C., der Linden, A. V., & Dommisse, R. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.001 · Cited by 83 · see citing works
Increased thirst and drinking in Huntington's disease and the R6/2 mouse
Wood, N. I., Goodman, A. O. G., van der Burg, J. M. M., Gazeau, V., Brundin, P., Björkqvist, M., Petersén, Å., Tabrizi, S. J., Barker, R. A., & Morton, A. J. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.12.007 · Cited by 83 · see citing works
Brooks, S. P., Higgs, G. V., Janghra, N., Jones, L., & Dunnett, S. B. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.05.005 · Cited by 82 · see citing works
Energy balance in early-stage Huntington disease
Gaba, A., Zhang, K., Marder, K. S., Moskowitz, C. B., Werner, P., & Boozer, C. N. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1335 · Cited by 81 · see citing works
Upper gastrointestinal findings in Huntington’s disease: patients suffer but do not complain
Andrich, J., Wobben, M., Klotz, P., Goetze, O., & Carsten Saft, C. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0310-1 · Cited by 63 · see citing works
Brooks, S. P., Janghra, N., Workman, V. L., Bayram-Weston, Z., Jones, L., & Dunnett, S. B. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.01.010 · Cited by 58 · see citing works
Meningeal cells can communicate with astrocytes by calcium signaling
Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works
High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice
Mo, C., Pang, T. Y., Ransome, M. I., Hill, R., Renoir, T., & Hannan, A. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.004 · Cited by 34 · see citing works
Self-citationFarhadi, F., Vosoughi, K., Shahidi, G. A., Delbari, A., Lökk, J., & Fereshtehnejad, S. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s124984 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Koroshetz, W.J., Jenkins, B.G., Rosen, B.R., Beal, M.F., 1997. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10. Ann. Neurol. 41 (2), 160-165.
- Pratley, R.E., Salbe, A.D., Ravussin, E., Caviness, J.N., 2000. Higher sedentary energy expenditure in patients with Huntington's disease. Ann. Neurol. 47 (1), 64-70.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Antibiotics, gut microbiota, and Alzheimer’s disease
Angelucci, F., Cechova, K., Amlerova, J., & Hort, J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1494-4 · Cited by 454 · see citing works
Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 381 · see citing works
Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works
Self-citationMicrobiota medicine: towards clinical revolution
Gebrayel, P., Nicco, C., Khodor, S. A., Biliński, J., Caselli, E., Comelli, E. M., Egert, M., Giaroni, C., Karpiński, T. M. M., Łoniewski, I., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03296-9 · Cited by 288 · see citing works
The Microbiome as a Modifier of Neurodegenerative Disease Risk
Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Wasser, C. I., Mercieca, E.-C., Kong, G., Hannan, A. J., McKeown, S. J., Glikmann-Johnston, Y., & Stout, J. C. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa110 · Cited by 198 · see citing works
Self-citationKabir, M. T., Rahman, M. H., Shah, M., Jamiruddin, M. R., Basak, D., Al‐Harrasi, A., Bhatia, S., Ashraf, G. M., Najda, A., El-kott, A. F., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112610 · Cited by 184 · see citing works
Kandpal, M., Indari, O., Baral, B., Jakhmola, S., Tiwari, D., Bhandari, V., Pandey, R. K., Bala, K., Sonawane, A., & Jha, H. C. (2022) · Metabolites · doi:10.3390/metabo12111064 · Cited by 172 · see citing works
Implications of Gut Microbiota in Neurodegenerative Diseases
Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 157 · see citing works
Enteric nervous system: the bridge between the gut microbiota and neurological disorders
Geng, Z.-H., Zhu, Y., Li, Q.-L., Zhao, C., & Zhou, P.-H. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.810483 · Cited by 144 · see citing works
Managing batch effects in microbiome data
Wang, Y., & Cao, K. L. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bbz105 · Cited by 136 · see citing works
Self-citationThe Relationship Between the Gut Microbiome and Neurodegenerative Diseases
Zhu, X., Li, B., Lou, P., Dai, T., Chen, Y., Zhuge, A., Yuan, Y., & Li, L. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00730-8 · Cited by 134 · see citing works
Current and Possible Future Therapeutic Options for Huntington’s Disease
Ferguson, M. W., Kennedy, C. J., Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221092517 · Cited by 126 · see citing works
Bicknell, B. T., Liebert, A. D., Borody, T. J., Herkes, G., McLachlan, C. S., & Kiat, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119577 · Cited by 129 · see citing works
Altered Gut Microbiota Related to Inflammatory Responses in Patients With Huntington’s Disease
Du, G., Dong, W., Yang, Q., Yu, X., Ma, J., Gu, W., & Huang, Y. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.603594 · Cited by 124 · see citing works
Kong, G., Ellul, S., Narayana, V. K., Kanojia, K., Tran, H., Li, S., Renoir, T., Cao, K. L., & Hannan, A. J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105199 · Cited by 110 · see citing works
Self-citationPraveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 112 · see citing works
Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease
Stan, T. L., Soylu-Kucharz, R., Burleigh, S., Prykhodko, O., Cao, L., Franke, N., Sjögren, M., Haikal, C., Hållenius, F., & Björkqvist, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-75229-9 · Cited by 101 · see citing works
Understanding the host-microbe interactions using metabolic modeling
Jansma, J., & Aidy, S. E. (2021) · Microbiome · doi:10.1186/s40168-020-00955-1 · Cited by 102 · see citing works
Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma
Ntranos, A., Park, H.-J., Wentling, M., Tolstikov, V., Amatruda, M., Inbar, B., Kim‐Schulze, S., Frazier, C., Button, J., Kiebish, M. A., et al. (2021) · Brain · doi:10.1093/brain/awab320 · Cited by 101 · see citing works
Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance
Tiwari, P., Dwivedi, R., Bansal, M., Tripathi, M., & Dada, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041650 · Cited by 106 · see citing works
The microbiota–microglia axis in central nervous system disorders
Mossad, O., & Erny, D. (2020) · Brain Pathology · doi:10.1111/bpa.12908 · Cited by 98 · see citing works
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
Xu, H., Huang, H., Zhou, Y., Zhao, H., Xu, J., Shou, D., Liu, Y., Zhou, Y., & Nie, Y. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6699268 · Cited by 103 · see citing works
Brain modulation by the gut microbiota: From disease to therapy
Mitra, S., Dash, R., Nishan, A. A., Habiba, S. U., & Moon, I. S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2022.12.001 · Cited by 87 · see citing works
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 134 · see citing works
Chen, Y., Li, Y., Fan, Y., Chen, S., Chen, L., Chen, Y., & Chen, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302310 · Cited by 91 · see citing works
Bile acids and neurological disease
Hurley, M. J., Bates, R., Macnaughtan, J., & Schapira, A. H. V. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108311 · Cited by 82 · see citing works
Gut Microbiota: Implications in Alzheimer’s Disease
He, Y., Li, B., Sun, D., & Chen, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072042 · Cited by 81 · see citing works
Peng, W., Yi, P., Yang, J., Xu, P., Wang, Y., Zhang, Z., Huang, S., Wang, Z., & Zhang, C. (2018) · Aging · doi:10.18632/aging.101693 · Cited by 80 · see citing works
Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders
Toledo, A. R. L., Monroy, G. R., Salazar, F. E., Lee, J.-Y., Jain, S., Yadav, H., & Borlongan, C. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031184 · Cited by 81 · see citing works
Altered Cholesterol Homeostasis in Huntington’s Disease
Kacher, R., Mounier, C., Caboche, J., & Bétuing, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.797220 · Cited by 72 · see citing works
Gubert, C., Choo, J. M., Love, C. J., Kodikara, S., Masson, B. A., Liew, J. J. M., Wang, Y., Kong, G., Narayana, V. K., Renoir, T., et al. (2022) · Brain Communications · doi:10.1093/braincomms/fcac205 · Cited by 71 · see citing works
Self-citationGut microbiome and cardiovascular disease
Zhao, Y., & Wang, Z. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000720 · Cited by 68 · see citing works
Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 69 · see citing works
Radulescu, C. I., Garcia‐Miralles, M., Sidik, H., Bardile, C. F., Yusof, N. A. B. M., Lee, H. U., Ho, E. X. P., Chu, C. W., Layton, E., Low, D., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.011 · Cited by 68 · see citing works
Cheng, W., Ho, J. Y. S., & Chang, R. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101620 · Cited by 70 · see citing works
Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis
Chuang, C.-L., & Demontis, F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101358 · Cited by 64 · see citing works
Sex and Gender Differences in Alzheimer’s Disease: Genetic, Hormonal, and Inflammation Impacts
Kolahchi, Z., Henkel, N., Eladawi, M. A., Villarreal, E. C., Kandimalla, P., Lundh, A., McCullumsmith, R. E., & Cuevas, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158485 · Cited by 63 · see citing works
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
Ekwudo, M. N., Gubert, C., & Hannan, A. J. (2024) · FEBS Journal · doi:10.1111/febs.17102 · Cited by 60 · see citing works
Self-citationTarget Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease
Zhu, F., Li, C., Chu, F., Tian, X., & Zhu, J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.544235 · Cited by 58 · see citing works
Gut Microbiota and Neuroplasticity
Murciano-Brea, J., García-Montes, M. E., Geuna, S., & Herrera‐Rincon, C. (2021) · Cells · doi:10.3390/cells10082084 · Cited by 59 · see citing works
Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington’s Disease
Paldino, E., Balducci, C., Vitola, P. L., Artioli, L., D’Angelo, V., Giampà, C., Artuso, V., Forloni, G., & Fusco, F. R. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01847-8 · Cited by 56 · see citing works
The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases
Zhang, L., Zhang, W., & Tian, X. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1924707 · Cited by 54 · see citing works
Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders
Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 58 · see citing works
Gut Microbiota and Alzheimer’s Disease: How to Study and Apply Their Relationship
Nguyen, N. M., Cho, J., & Lee, C.-H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044047 · Cited by 57 · see citing works
Effects of gut microbiota on neurodegenerative diseases
Khatoon, S., Kalam, N., Rashid, S., & Bano, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1145241 · Cited by 51 · see citing works
Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders
Chandra, S., Alam, M. T., Dey, J., Sasidharan, B. C. P., Ray, U., Srivastava, A. K., Gandhi, S., & Tripathi, P. P. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200413091101 · Cited by 51 · see citing works
Gene targeting techniques for Huntington’s disease
Fields, E., Vaughan, E., Tripu, D. R., Lim, I., Shrout, K., Conway, J., Salib, N., Lee, Y., Dhamsania, A., Jacobsen, M., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101385 · Cited by 48 · see citing works
Self-citationSingh, N., Singh, V., Nand, S., Mishra, V., Vamanu, E., & Singh, M. P. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113958 · Cited by 52 · see citing works
Sharma, G., Biswas, S. S., Mishra, J., Navik, U., Kandimalla, R. J. L., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121882 · Cited by 46 · see citing works
Dietary fibre confers therapeutic effects in a preclinical model of Huntington’s disease
Gubert, C., Kong, G., Costello, C., Adams, C. D., Masson, B. A., Qin, W., Choo, J. M., Narayana, V. K., Rogers, G. B., Renoir, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.023 · Cited by 45 · see citing works
Self-citationThe Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects
Li, R., Miao, Z., Liu, Y., Chen, X., Wang, H., Su, J.-C., & Chen, J.-X. (2024) · Advancement of science · doi:10.1002/advs.202307971 · Cited by 54 · see citing works
Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health
Cocean, A.-M., & Vodnar, D. C. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111073 · Cited by 48 · see citing works
Alterations in the Gut Fungal Community in a Mouse Model of Huntington’s Disease
Kong, G., Cao, K. L., & Hannan, A. J. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02192-21 · Cited by 43 · see citing works
Self-citationGubert, C., Love, C. J., Kodikara, S., Mei Liew, J. J., Renoir, T., Lê Cao, K.-A., & Hannan, A. J. (2022) · iScience · doi:10.1016/j.isci.2021.103687 · Cited by 41 · see citing works
Self-citationMunir, M. U., Ali, S. A., Chung, K. H. K., Käkinen, A., Javed, I., & Davis, T. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2422468 · Cited by 44 · see citing works
Perez, L., Scarcello, E., Ibouraadaten, S., Yakoub, Y., Leinardi, R., Ambroise, J., Bearzatto, B., Gala, J., Paquot, A., Muccioli, G. G., et al. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112352 · Cited by 40 · see citing works
Why Woody got the blues: The neurobiology of depression in Huntington's disease
Gubert, C., Renoir, T., & Hannan, A. J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104958 · Cited by 40 · see citing works
Self-citationvan den Brûle, S., Rappe, M., Ambroise, J., Bouzin, C., Dessy, C., Paquot, A., Muccioli, G. G., & Lison, D. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00400-7 · Cited by 40 · see citing works
Butyrate as a potential therapeutic agent for neurodegenerative disorders
Chakraborty, P., Gamage, H. K. A. H., & Laird, A. S. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105745 · Cited by 41 · see citing works
Gut dysbiosis and age-related neurological diseases in females
Korf, J. M., Ganesh, B. P., & McCullough, L. D. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105695 · Cited by 41 · see citing works
Chiu, L. S., & Anderton, R. S. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15892 · Cited by 35 · see citing works
Hasan, A., Scuderi, S. A., Capra, A. P., Giosa, D., Bonomo, A., Ardizzone, A., & Esposito, E. (2025) · Brain Sciences · doi:10.3390/brainsci15060654 · Cited by 36 · see citing works
Retinitis pigmentosa is associated with shifts in the gut microbiome
Kutsyr, O., Maestre‐Carballa, L., Gómez, M. L., Martínez‐García, M., Cuenca, N., & Lax, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-86052-1 · Cited by 37 · see citing works
Chatterjee, A., Kumar, S., Sarkar, S. R., Halder, R., Kumari, R., Banerjee, S., & Sarkar, B. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109622 · Cited by 36 · see citing works
Fleischer, R., Schmid, D. W., Wasimuddin, Brändel, S. D., Rasche, A., Corman, V. M., Drosten, C., Tschapka, M., & Sommer, S. (2022) · Molecular Ecology · doi:10.1111/mec.16491 · Cited by 35 · see citing works
Gut microbes and host behavior: The forgotten members of the gut-microbiome
Weiner, A., Turjeman, S. C., & Koren, O. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109453 · Cited by 33 · see citing works
Metabolism in Huntington’s disease: a major contributor to pathology
Singh, A., & Agrawal, N. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00844-y · Cited by 33 · see citing works
Oligodendrocyte pathology in Huntington’s disease: from mechanisms to therapeutics
Bardile, C. F., Radulescu, C. I., & Pouladi, M. A. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.07.010 · Cited by 34 · see citing works
What, When and How to Measure—Peripheral Biomarkers in Therapy of Huntington’s Disease
Przybył, Ł., Woźna, M., Kozłowska, E., & Fiszer, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041561 · Cited by 33 · see citing works
Nargeh, H., Aliabadi, F., Ajami, M., & Pazoki–Toroudi, H. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00923 · Cited by 31 · see citing works
Marć, M. A., Jastrząb, R., & Mytych, J. (2022) · Nutrients · doi:10.3390/nu14193967 · Cited by 33 · see citing works
Gut Bacteria Regulate the Pathogenesis of Huntington’s Disease in Drosophila Model
Chongtham, A., Yoo, J. H., Chin, T. M., Akingbesote, N. D., Huda, A., Marsh, J., & Khoshnan, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.902205 · Cited by 31 · see citing works
Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease
Sterling, K. G., Dodd, G. K., Alhamdi, S., Asimenios, P. G., Dagda, R. K., Meirleir, K. L. D., Hudig, D., & Lombardi, V. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113328 · Cited by 31 · see citing works
What the Gut Tells the Brain—Is There a Link between Microbiota and Huntington’s Disease?
Wronka, D., Karlik, A., Misiorek, J. O., & Przybył, Ł. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054477 · Cited by 30 · see citing works
A Randomized Controlled Trial of Probiotics Targeting Gut Dysbiosis in Huntington’s Disease
Wasser, C. I., Mercieca, E., Kong, G., Hannan, A. J., Allford, B., McKeown, S. J., Stout, J. C., & Glikmann‐Johnston, Y. (2023) · Journal of Huntington s Disease · doi:10.3233/jhd-220556 · Cited by 30 · see citing works
Self-citationThe Emerging Landscape of Natural Small-molecule Therapeutics for Huntington’s Disease
Bhat, S. A., Ahamad, S., Dar, N. J., Siddique, Y. H., & Nazir, A. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230216104621 · Cited by 29 · see citing works
Inflammation and Huntington’s disease – a neglected therapeutic target?
Field, S., Curle, A. J., & Barker, R. A. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348738 · Cited by 28 · see citing works
Picó, S., Parras, A., Santos‐Galindo, M., Pose‐Utrilla, J., Castro, M., Fraga, E., Hernández, I. H., Elorza, A., Anta, H., Wang, N., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe7104 · Cited by 27 · see citing works
Systemic Symptoms in Huntington's Disease: A Comprehensive Review
Mehanna, R., & Jankovic, J. J. (2024) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.14029 · Cited by 25 · see citing works
The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans
Fabi, J. P. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01369-w · Cited by 25 · see citing works
Masson, B. A., Kiridena, P., Da, L., Kleeman, E. A., Reisinger, S. N., Qin, W., Davies, W. J., Muralitharan, R. R., Jama, H. A., Antonacci, S., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.020 · Cited by 25 · see citing works
Self-citationAhmed, L. A., & Al‐Massri, K. F. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220222105004 · Cited by 23 · see citing works
Cescon, M., Gambarotta, G., Calabrò, S., Cicconetti, C., Anselmi, F., Kankowski, S., Lang, L., Basic, M., Bleich, A., Bolsega, S., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363015 · Cited by 23 · see citing works
Gut-Brain Axis Deregulation and Its Possible Contribution to Neurodegenerative Disorders
Villavicencio-Tejo, F., Olesen, M. A., Navarro, L., Calisto, N., Iribarren, C., GARCÍA, K. P., Corsini, G., & Quintanilla, R. A. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00681-0 · Cited by 23 · see citing works
Classical methods and perspectives for manipulating the human gut microbial ecosystem
Avalos, J. A. J., Arrevillaga-Boni, G., González‐López, L., García-Carvajal, Z. Y., & González‐Ávila, M. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1724075 · Cited by 23 · see citing works
Marchionini, D. M., Liu, J.-P., Ambesi‐Impiombato, A., Kerker, K., Cirillo, K., Bansal, M., Mushlin, R., Brunner, D., Ramboz, S., Kwan, M. Y., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161769 · Cited by 22 · see citing works
Gut Microbiota as a Modifier of Huntington’s Disease Pathogenesis
Khoshnan, A. (2024) · Journal of Huntington s Disease · doi:10.3233/jhd-240012 · Cited by 22 · see citing works
Effect of Short Chain Fatty Acids on Age-Related Disorders
Fernandes, M. F., de Oliveira, S., Portovedo, M., Rodrigues, P. B., & Vinolo, M. A. R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_4 · Cited by 22 · see citing works
Balakrishnan, R., Kang, S.-I., Lee, J. Y., Rho, Y., Kim, B.-K., & Choi, D. (2024) · Aging and Disease · doi:10.14336/ad.2024.1362 · Cited by 22 · see citing works
Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases
Guo, Y., Wang, S., Chao, X., Li, D., Wang, Y., Guo, Q., & Chen, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1026688 · Cited by 21 · see citing works
Zielonka, D., Witkowski, G., Puch, E. A., Leśniczak-Staszak, M., Mazur-Michałek, I., Isalan, M., & Mielcarek, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00079 · Cited by 21 · see citing works
Mateo, D., Marquès, M., Domingo, J. L., & Torrente, M. (2023) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32959 · Cited by 21 · see citing works
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder
Trujillo-Del Río, C., Tortajada-Pérez, J., Gómez-Escribano, A. P., Casterá, F., Peiró, C., Millán, J. M., Herrero, M. J., & Vázquez-Manrique, R. P. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111670 · Cited by 19 · see citing works
Peng, Z., Hou, T., Yang, K., Zhang, J., Mao, Y.-H., & Hou, X. (2025) · Nutrients · doi:10.3390/nu17111769 · Cited by 19 · see citing works
- Authors
- Kong, G., Cao, K.-A. L., Judd, L. M., Li, S., Renoir, T., & Hannan, A. J.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Hannan, Anthony J.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 135
- Pages
- 104268
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2889638535
- Cited by
- 212
- References
- 60
- Citations by year
- 2026: 13 · 2025: 35 · 2024: 39 · 2023: 27 · 2022: 37 · 2021: 32 · 2020: 20 · 2019: 7 · 2018: 1 · 2017: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NHMRC (GNT1087415)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Huntington's disease, gut dysbiosis, gut microbiota, Bacteroidetes, Firmicutes, microbial diversity, sex differences, weight gain, motor impairment, fecal water content
- MeSH terms
- Gastrointestinal Microbiome, Huntingtin Protein, Animals, Brain, Disease Models, Animal, Huntington Disease, Male, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Trinucleotide Repeat Expansion, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
