Breath holding reveals differences in fMRI BOLD signal in children and adults
Abstract
Application of fMRI to studies of cognitive development is of growing interest because of its sensitivity and non-invasive nature. However, interpretation of fMRI results in children is presently based on vascular dynamics that have been studied primarily in healthy adults. Comparison of the neurological basis of cognitive development is valid to the extent that the neurovascular responsiveness between children and adults is equal. The present study was designed to detect age-related vascular differences that may contribute to altered BOLD fMRI signal responsiveness. We examined BOLD signal changes in response to breath holding, a global, systemic state change in brain oxygenation. Children exhibited greater percent signal changes than adults in grey and white matter, and this was accompanied by an increase in noise. Consequently, the volume of activation exceeding statistical threshold was reduced in children. The reduced activation in children was well modeled by adding noise to adult data. These findings raise the possibility that developmental differences in fMRI findings between children and adults could, under some circumstances, reflect greater noise in the BOLD response in the brains of children than adults. BOLD responses varied across brain regions, but showed similar regional variation in children and adults.
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There is a 'diffuse-to-focal' shift in BOLD signal between childhood and adulthood.
“It has been observed that there is a ‘diffuse-to-focal’ shift in BOLD signal between childhood and adulthood (Durston et al., 2006; Thomason et al., 2005).”
From The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies (2011) · cites this paper as Thomason et al., 2005
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- Authors
- Thomason, M. E., Burrows, B. E., Gabrieli, J. D. E., & Glover, G. H.
- Affiliations
- Stanford University (US)
- Stanford Medicine (US)
- Corresponding author
- Thomason, Moriah E.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 25
- Issue
- 3
- Pages
- 824-837
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2129291315
- Cited by
- 174
- References
- 71
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 11 · 2016: 12 · 2015: 6 · 2014: 10 · 2013: 10 · 2012: 7
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH61426, R01MH061426)
- National Center for Research Resources (RR 09784, P41RR009784)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- breath-holding, BOLD signal, children versus adults, neurovascular coupling, cognitive development, cerebral oxygenation, brain activation, gray and white matter
- MeSH terms
- Adolescent, Adult, Aging, Inhalation, Brain, Child, Female, Heart Rate, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Reference Values, Regional Blood Flow, Respiration, Artifacts, Imaging, Three-Dimensional
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