Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment

Chetelat, G.

doi:10.1093/brain/awg196

Cited by 264Dementia and Cognitive Impairment ResearchMemory Processes and InfluencesCognitive Functions and Memory

Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment

Chetelat, G.·2003·Brain

DOI 10.1093/brain/awg196

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Abstract

The present study aims to unravel, in the same study, both morphological and functional specific substrates of encoding versus retrieval deficits in patients with amnestic mild cognitive impairment (MCI). For this purpose, 21 highly screened MCI patients with isolated memory impairment, who attended a memory clinic and fulfilled operational criteria for MCI, underwent (i) two episodic memory subtests designed to assess preferentially either incidental encoding or retrieval capacity; (ii) a high-resolution T1-weighted volume MRI scan; and (iii) a resting state [18F]fluoro-2-deoxy-D-glucose PET study. Using statistical parametric mapping, positive correlations between memory scores on one hand, and grey matter density and normalized partial volume effect-corrected brain glucose utilization (ncCMRglc) on the other hand, were computed. Deficits in both encoding and retrieval were correlated with declines in hippocampal region grey matter density. The encoding subtest also correlated with hippocampal ncCMRglc, whereas the retrieval subtest correlated with the posterior cingulate area ncCMRglc only. The present findings highlight a distinction in the neural substrates of encoding and retrieval deficits in MCI. Furthermore, they unravel a partial dissociation between metabolic and structural correlates, suggesting distinct interpretations. Hippocampal atrophy was related to both encoding and retrieval deficits, possibly reflecting a direct effect on hippocampal functioning, as well as an indirect effect, through remote functional disruption, on posterior cingulate region synaptic function, respectively.

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In prodromal Alzheimer's disease, the posterior cingulate cortex undergoes early hypometabolism.
“while the posterior cingulate cortex undergoes early hypometabolism [15,53].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [15]

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The Investigation of Fluoro-deoxy-glucose PET in Alzheimer's Disease and Mild Cognitive Impairment Using Statistical Parametric Mapping
Yi-hui, G. (2013) · Chinese Journal of Clinical Neurosciences

Authors: Chetelat, G.
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 2003-09-01
Volume: 126
Issue: 9
Pages: 1955-1967
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/awg196
OpenAlex: W2152947287
Cited by: 264
References: 74
Citations by year: 2026: 1 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 11 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 14 · 2015: 12 · 2014: 14 · 2013: 16 · 2012: 14
FWCI: 9.85
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: amnestic mild cognitive impairment, episodic memory, memory encoding, memory retrieval, hippocampal atrophy, posterior cingulate cortex, brain glucose metabolism, neuroimaging of memory
MeSH terms: Aged, Atrophy, Brain, Cognition Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Memory Disorders, Middle Aged, Prospective Studies, Statistics as Topic, Tomography, Emission-Computed, Radiopharmaceuticals, Fluorodeoxyglucose F18

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Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment

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