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Cited by 1,188

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Topography of the human corpus callosum revisited—Comprehensive fiber tractography using diffusion tensor magnetic resonance imaging

Open access
Hofer, Sabine, Frahm, Jens·2006·NeuroImage
DOI 10.1016/j.neuroimage.2006.05.044
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Abstract

Several tracing studies have established a topographical distribution of fiber connections to the cortex in midsagittal cross-sections of the corpus callosum (CC). The most prominent example is Witelson's scheme, which defines five vertical partitions mainly based on primate data. Conventional MRI of the human CC does not reveal morphologically discernable structures, although microscopy techniques identified myelinated axons with a relatively small diameter in the anterior and posterior third of the CC as opposed to thick fibers in the midbody and posterior splenium. Here, we applied diffusion tensor imaging (DTI) in conjunction with a tract-tracing algorithm to gain cortical connectivity information of the CC in individual subjects. With DTI-based tractography, we distinguished five vertical segments of the CC, containing fibers projecting into prefrontal, premotor (and supplementary motor), primary motor, and primary sensory areas as well as into parietal, temporal, and occipital cortical areas. Striking differences to Witelson's classification were recognized in the midbody and anterior third of the CC. In particular, callosal motor fiber bundles were found to cross the CC in a much more posterior location than previously indicated. Differences in water mobility were found to be in qualitative agreement with differences in the microstructure of transcallosal fibers yielding the highest anisotropy in posterior regions of the CC. The lowest anisotropy was observed in compartments assigned to motor and sensory cortical areas. In conclusion, DTI-based fiber tractography of healthy human subjects suggests a modification of the widely accepted Witelson scheme and a new classification of vertical CC partitions.

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Metadata

Authors
Hofer, S., & Frahm, J.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2006-09
Volume
32
Issue
3
Pages
989-994
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2006.05.044
OpenAlex
W2115428913
Cited by
1,188
References
1
FWCI
29.22
Type
journal article
Language
en
Open access
hybrid

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