Amygdala–prefrontal coupling underlies individual differences in emotion regulation
Open accessAbstract
Despite growing evidence on the neural bases of emotion regulation, little is known about the mechanisms underlying individual differences in cognitive regulation of negative emotion, and few studies have used objective measures to quantify regulatory success. Using a trait-like psychophysiological measure of emotion regulation, corrugator electromyography, we obtained an objective index of the ability to cognitively reappraise negative emotion in 56 healthy men (Session 1), who returned 1.3 years later to perform the same regulation task using fMRI (Session 2). Results indicated that the corrugator measure of regulatory skill predicted amygdala-prefrontal functional connectivity. Individuals with greater ability to down-regulate negative emotion as indexed by corrugator at Session 1 showed not only greater amygdala attenuation but also greater inverse connectivity between the amygdala and several sectors of the prefrontal cortex while down-regulating negative emotion at Session 2. Our results demonstrate that individual differences in emotion regulation are stable over time and underscore the important role of amygdala-prefrontal coupling for successful regulation of negative emotion.
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Deficits in voluntary emotion regulation circuit (amygdala-dmPFC) may play an important role in impaired regulation of negative emotion in pediatric PTSD.
“deficits in this key voluntary emotion regulation circuit [58,60] may play an important role in impaired regulation of negative emotion in pediatric PTSD.”
From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [60]
The Results and Discussion link stronger inverse amygdala–PFC coupling, including dmPFC, with better down-regulation of negative emotion. The study used a male-only sample and does not establish that deficits in this circuit contribute to impaired regulation in pediatric PTSD; that application goes beyond its findings. Page numbers were not available in our copy. (LLM, conf=0.86)
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- Authors
- Lee, H., Heller, A. S., van Reekum, C. M., Nelson, B., & Davidson, R. J.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Illinois Chicago (US)
- Corresponding author
- Davidson, Richard J.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 62
- Issue
- 3
- Pages
- 1575-1581
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3408571
- OpenAlex
- W2155444575
- Cited by
- 219
- References
- 56
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 16 · 2018: 20 · 2017: 19 · 2016: 23 · 2015: 13 · 2014: 16 · 2013: 12
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01-MH43454, P50-MH069315)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- emotion regulation, individual differences, amygdala, prefrontal cortex, cognitive reappraisal, negative emotions, longitudinal stability
- MeSH terms
- Amygdala, Brain Mapping, Electromyography, Emotions, Humans, Individuality, Magnetic Resonance Imaging, Male, Neural Pathways, Prefrontal Cortex, Young Adult
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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