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Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex
Open accessAbstract
Nicotine enhances attention and working memory by activating nicotinic acetylcholine receptors (nAChRs). The prefrontal cortex (PFC) is critical for these cognitive functions and is also rich in nAChR expression. Specific cellular and synaptic mechanisms underlying nicotine's effects on cognition remain elusive. Here we show that nicotine exposure increases the threshold for synaptic spike-timing-dependent potentiation (STDP) in layer V pyramidal neurons of the mouse PFC. During coincident presynaptic and postsynaptic activity, nicotine reduces dendritic calcium signals associated with action potential propagation by enhancing GABAergic transmission. This results from a series of presynaptic actions involving different PFC interneurons and multiple nAChR subtypes. Pharmacological block of nAChRs or GABA(A) receptors prevented nicotine's actions and restored STDP, as did increasing dendritic calcium signals with stronger postsynaptic activity. Thus, by activating nAChRs distributed throughout the PFC neuronal network, nicotine affects PFC information processing and storage by increasing the amount of postsynaptic activity necessary to induce STDP.
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“In contrast, in layer V pyramidal neurons, activation of presynaptic β2* nAChRs on glutamatergic inputs from the thalamus strongly enhances activity of these neurons (Gioanni et al. 1999; Lambe et al. 2003; Couey et al. 2007; Poorthuis et al. 2012).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Couey et al. 2007
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“This may affect plasticity and refinement of cortical connections (Couey et al. 2007)”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Couey et al. 2007
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“In addition, nicotine in the mPFC changes the rules for spike-timing-dependent plasticity and thereby prevents synaptic potentiation (34).”
From Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex (2012) · cites this paper as [34]
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“the majority of interneurons express nAChRs that are composed of α4β2*, although they also express other subunits (34)”
From Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex (2012) · cites this paper as [34]
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“Increased inhibition can lead to blockade of long-term potentiation (LTP) induction in the hippocampus (Ji et al. 2001) and increase in the threshold for induction of spike-timing-dependent plasticity (STDP) (Couey et al. 2007).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Couey et al. 2007
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“nAChR, which enhances both excitatory and inhibitory synaptic transmission (Lambe et al. 2003; Couey et al. 2007; Poorthuis et al. 2012).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Couey et al. 2007
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“In addition, different types of PFC interneurons in the mPFC express both α7 and α4β2-containing nAChRs on their cell bodies (34), and nAChR stimulation increases GABAergic transmission (34).”
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“In contrast to the ability of nAChR stimulation to promote LTP in a number of brain areas, nAChR-mediated facilitation of GABA release reduces calcium levels in prefronto-cortical dendrites (Couey et al., 2007).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Couey et al., 2007
In the citing paper
“The fast inhibition is at least partially mediated by the actions of both nAChRs and mAChRs that increase the excitability and firing rates of dendrite-targeting GABAergic interneurons (Arroyo et al., 2012; Couey et al., 2007; Fanselow et al., 2008; Ferezou et al., 2002; Gulledge et al., 2007; Kawaguchi and Kubota, 1997).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Couey et al., 2007
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Citations
Cites
Bi, G.-Q., & Poo, M.-M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10464.1998 · Cited by 4,744
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Tsien, R. Y. (1980) · Biochemistry · doi:10.1021/bi00552a018 · Cited by 2,261
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons
Magee, J. C., & Johnston, D. (1997) · Science · doi:10.1126/science.275.5297.209 · Cited by 1,340
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947
Heidbreder, C. A., & Groenewegen, H. J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.09.003 · Cited by 882
Jay, T. M., & Witter, M. P. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130404 · Cited by 841
Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission
Malenka, R. C., Kauer, J. A., Zucker, R. S., & Nicoll, R. A. (1988) · Science · doi:10.1126/science.2845577 · Cited by 829
Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820
Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells
Silberberg, G., & Markram, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.012 · Cited by 768
Action potential initiation and backpropagation in neurons of the mammalian CNS
Stuart, G., Spruston, N., Sakmann, B., & Häusser, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10075-8 · Cited by 768
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720
Self-citationSynaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701
Self-citationPRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE
MacDermott, A. B., Role, L. W., & Siegelbaum, S. A. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.443 · Cited by 570
Nicotinic systems and cognitive function
Levin, E. D. (1992) · Psychopharmacology · doi:10.1007/bf02247415 · Cited by 511
Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat
Berendse, H. W., & Groenewegen, H. J. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90151-d · Cited by 503
The prefrontal cortex and the integration of sensory, limbic and autonomic information
Groenewegen, H. J., & Uylings, H. B. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26003-2 · Cited by 454
Cellular and synaptic mechanisms of nicotine addiction
Mansvelder, H. D., & McGehee, D. S. (2002) · Journal of Neurobiology · doi:10.1002/neu.10148 · Cited by 450
Self-citationCholinergic Switching Within Neocortical Inhibitory Networks
Xiang, Z., Huguenard, J. R., & Prince, D. A. (1998) · Science · doi:10.1126/science.281.5379.985 · Cited by 438
Timing and Location of Nicotinic Activity Enhances or Depresses Hippocampal Synaptic Plasticity
Ji, D., Lape, R., & Dani, J. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00332-4 · Cited by 419
Effects of nicotinic stimulation on cognitive performance
NEWHOUSE, P. A. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.001 · Cited by 411
Spike-timing-dependent synaptic plasticity depends on dendritic location
Froemke, R. C., Poo, M., & Dan, Y. (2005) · Nature · doi:10.1038/nature03366 · Cited by 403
Kawaguchi, Y., & Kondo, S. (2002) · Journal of Neurocytology · doi:10.1023/a:1024126110356 · Cited by 395
Kawaguchi, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.2.416 · Cited by 390
Nicotine addiction and comorbidity with alcohol abuse and mental illness
Dani, J. A., & Harris, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1580 · Cited by 382
Higher levels of nicotine in arterial than in venous blood after cigarette smoking
Henningfield, J. E. (1993) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(93)90030-t · Cited by 370
Koester, H. J., & Sakmann, B. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9596 · Cited by 348
Classification of fusiform neocortical interneurons based on unsupervised clustering
Cauli, B., Porter, J. T., Tsuzuki, K., Lambolez, B., Rossier, J., Quenet, B., & Audinat, E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6144 · Cited by 316
Nicotine: from molecular mechanisms to behaviour
Wonnacott, S., Sidhpura, N., & Balfour, D. J. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.12.002 · Cited by 263
Nicotine Induces Glutamate Release from Thalamocortical Terminals in Prefrontal Cortex
Lambe, E. K., Picciotto, M. R., & Aghajanian, G. K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300032 · Cited by 261
Laroche, S., Jay, T. M., & Thierry, A. M. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90069-l · Cited by 261
Yang, C., Seamans, J. K., & Gorelova, N. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01904.1996 · Cited by 257
Alkondon, M., Pereira, E. F. R., Eisenberg, H. M., & Albuquerque, E. X. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00066.2000 · Cited by 248
Tsubokawa, H., & Ross, W. N. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.2896 · Cited by 246
Vidal, C., & Changeux, J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90558-w · Cited by 240
Alkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 238
Presynaptic nicotinic receptors modulating dopamine release in the rat striatum
Wonnacott, S., Kaiser, S., Mogg, A., Soliakov, L., & Jones, I. W. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00005-4 · Cited by 232
Spike timing, calcium signals and synaptic plasticity
Sjöström, P. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00325-2 · Cited by 231
Everitt, B. J., Robbins, T. W., & Muir, J. L. (1995) · Psychopharmacology · doi:10.1007/bf02245253 · Cited by 214
Nicotinic receptors in aging and dementia
Picciotto, M. R., & Zoli, M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10102 · Cited by 207
Nicotinic modulation of neuronal networks: from receptors to cognition
Mansvelder, H. D., van Aerde, K. I., Couey, J. J., & Brussaard, A. B. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0070-z · Cited by 202
Self-citationAlkondon, M., & Albuquerque, E. X. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45007-3 · Cited by 199
Dopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons
Otani, S. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg092 · Cited by 196
Heterogeneity of phasic cholinergic signaling in neocortical neurons
Gulledge, A. T., Park, S. B., Kawaguchi, Y., & Stuart, G. J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00493.2006 · Cited by 194
Gioanni, Y., Rougeot, C., Clarke, P. B. S., Lepousé, C., Thierry, A. M., & Vidal, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00403.x · Cited by 191
Nicotine enhances sustained attention in the rat under specific task conditions
Mirza, N. R., & Stolerman, I. P. (1998) · Psychopharmacology · doi:10.1007/s002130050671 · Cited by 181
Jay, T. M., Burette, F., & Laroche, S. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01060.x · Cited by 177
Meredith, R. M., Floyer-Lea, A., & Paulsen, O. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11142.2003 · Cited by 159
Self-citationPresynaptic ionotropic receptors
McGehee, D. S., & Role, L. W. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80118-8 · Cited by 157
Granon, S., Poucet, B., Thinus‐Blanc, C., Changeux, J., & Vidal, C. (1995) · Psychopharmacology · doi:10.1007/bf02246154 · Cited by 141
Improved quantitative real-time RT-PCR for expression profiling of individual cells
Liss, B. (2002) · Nucleic Acids Research · doi:10.1093/nar/gnf088 · Cited by 140
Ge, S., & Dani, J. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-05.2005 · Cited by 132
Matsuda, Y., Marzo, A., & Otani, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5312-05.2006 · Cited by 121
Nicotinic Acetylcholine Receptors in Sensory Cortex: Figure 1
Metherate, R. (2004) · Learning & Memory · doi:10.1101/lm.69904 · Cited by 116
Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders
NEWHOUSE, P. A., Singh, A., & Potter, A. S. (2004) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026043451401 · Cited by 106
Gulledge, A. T., & Stuart, G. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11363.2003 · Cited by 99
Day, M., Pan, J. B., Buckley, M. J., Cronin, E. A., Hollingsworth, P. R., Hirst, W. D., Navarra, R. L., Sullivan, J. P., Decker, M. W., & Fox, G. B. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.004 · Cited by 79
Vidal, C., & Changeux, J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90056-0 · Cited by 76
Chauvet, N., Apert, C., Dumoulin, A., Epelbaum, J., & Alonso, G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 23
Raising the speed limit – fast Ca2+ handling in dendritic spines
Helmchen, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02232-4 · Cited by 18
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways.
Lavenex (2000) · Pure Amsterdam UMC · doi:10.1002/1098-1063(2000)10:4 · Cited by 1
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Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Benchenane, K., Peyrache, A., Khamassi, M., Tierney, P. L., Gioanni, Y., Battaglia, F. P., & Wiener, S. I. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.013 · Cited by 872
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Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840
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Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 740
Metadata
- Authors
- Couey, J. J., Meredith, R. M., Spijker, S., Poorthuis, R. B., Smit, A. B., Brussaard, A. B., & Mansvelder, H. D.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Mansvelder, Huibert D.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 54
- Issue
- 1
- Pages
- 73-87
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2077516679
- Cited by
- 253
- References
- 68
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 5 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 11 · 2015: 12 · 2014: 21 · 2013: 22 · 2012: 18
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2335 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- ZonMw
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- nicotine, nicotinic acetylcholine receptors, spike-timing-dependent plasticity, prefrontal cortex, layer 5 pyramidal neurons, GABAergic neurotransmission, GABAA receptor, presynaptic inhibition, nAChR subtypes, working memory, attention
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Drug Interactions, Mice, Inbred C57BL, Models, Neurological, Nerve Net, Neuronal Plasticity, Neurons, Nicotine, Reaction Time, Receptors, Nicotinic, Prefrontal Cortex, Nicotinic Agonists, GABA Antagonists, Excitatory Postsynaptic Potentials, Calcium Signaling, Reverse Transcriptase Polymerase Chain Reaction, Mice, In Vitro Techniques
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