The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity
Open accessAbstract
Sleep is thought to consolidate changes in synaptic strength, but the underlying mechanisms are unknown. We investigated the cellular events involved in this process during ocular dominance plasticity (ODP)-a canonical form of in vivo cortical plasticity triggered by monocular deprivation (MD) and consolidated by sleep via undetermined, activity-dependent mechanisms. We find that sleep consolidates ODP primarily by strengthening cortical responses to nondeprived eye stimulation. Consolidation is inhibited by reversible, intracortical antagonism of NMDA receptors (NMDARs) or cAMP-dependent protein kinase (PKA) during post-MD sleep. Consolidation is also associated with sleep-dependent increases in the activity of remodeling neurons and in the phosphorylation of proteins required for potentiation of glutamatergic synapses. These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP.
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“Conversely, the GABA A agonist muscimol and also zolpidem impaired sleep-dependent plastic changes in the visual cortex in a developmental model of synaptic plasticity in cats [i.e., ocular dominance plasticity (ODP); see sect.VIIA3 for details] (48,411,1059), suggesting that GABA plays a critical role for plastic processes occurring during sleep.”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“Of the GABA A agonistic substances zaleplon, eszopiclone, zolpidem, and triazolam, only zolpidem impaired sleep-dependent ODP, although all substances distinctly reduced REM sleep and increased non-REM sleep (48,1059).”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“These sleep-dependent changes are prevented by blocking NMDA receptors or cAMP-dependent protein kinase (PKA) during sleep after monocular experience (48)”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“Sleep-dependent ODP is prevented by blocking glutamatergic NMDA receptors or cAMP-dependent protein kinase (PKA) during sleep after monocular deprivation (48).”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“The beneficial effect of sleep on consolidation of ODP mainly leads to a strengthening of the cortical responses to stimulation of the nondeprived eye (48).”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“ODP was impaired following application of the atypical hypnotic trazodone, probably acting via blocking 5-HT 2c receptors during sleep (48).”
From About Sleep's Role in Memory (2013) · cites this paper as [48]
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“Work in the visual cortex also shows that sleep affects memory consolidation,80–82”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [80]
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Citations
Cites
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
Hubel, D. H., & Wiesel, T. N. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009022 · Cited by 3,030
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity
Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M. F., & Huganir, R. L. (2000) · Nature · doi:10.1038/35016089 · Cited by 1,116
Sleep-Dependent Learning and Memory Consolidation
Walker, M. P., & Stickgold, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.031 · Cited by 1,113 · cited 1×
“, 2006) and that consolidation can occur during sleep (Frank and Benington, 2006; Walker and Stickgold, 2004).”
BackgroundReplay and Time Compression of Recurring Spike Sequences in the Hippocampus
Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09497.1999 · Cited by 932 · cited 2×
“, 2000; Pavlides and Winson, 1989; Wilson and McNaughton, 1994), which may provide sufficient neuronal depolarization to activate NMDARs (Nadasky et al., 1999).”
BackgroundExperience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 856
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · cited 2×
“First, we investigated a naturally occurring form of plasticity in vivo, whereas these authors examined artificial forms of induced plasticity (or electrically evoked responses) and gene and protein expression in animals whose brains were not stimulated to remodel (Cirelli et al., 2004; Vyazovskiy et al., 2008 ).”
BackgroundResultExperience-dependent changes in cerebral activation during human REM sleep
Maquet, P., Laureys, S., Peigneux, P., Fuchs, S., Petiau, C., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Meulemans, T., et al. (2000) · Nature Neuroscience · doi:10.1038/77744 · Cited by 747
Pavlides, C., & Winson, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02907.1989 · Cited by 684
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Fast-Forward Playback of Recent Memory Sequences in Prefrontal Cortex During Sleep
Euston, D. R., Tatsuno, M., & McNaughton, B. L. (2007) · Science · doi:10.1126/science.1148979 · Cited by 586
NMDA Receptor-Dependent Synaptic Reinforcement as a Crucial Process for Memory Consolidation
Shimizu, E., Tang, Y., Rampon, C., & Tsien, J. Z. (2000) · Science · doi:10.1126/science.290.5494.1170 · Cited by 546
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523
Self-citationBear, M., Kleinschmidt, A., Gu, Q., & Singer, W. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-03-00909.1990 · Cited by 488
How Monocular Deprivation Shifts Ocular Dominance in Visual Cortex of Young Mice
Frenkel, M. Y., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.003 · Cited by 412
Macromolecule biosynthesis: a key function of sleep
Mackiewicz, M., Shockley, K. R., Romer, M. A., Galante, R. J., Zimmerman, J. E., Naidoo, N. N., Baldwin, D. A., Jensen, S. T., Churchill, G. A., & Pack, A. I. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00275.2006 · Cited by 391
Wiltgen, B. J., Brown, R. A. M., Talton, L. E., & Silva, A. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.015 · Cited by 323
Signaling from cAMP/PKA to MAPK and Synaptic Plasticity
Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 303
A Causal Role for Brain-Derived Neurotrophic Factor in the Homeostatic Regulation of Sleep
Faraguna, U., Vyazovskiy, V. V., Nelson, A. B., Tononi, G., & Cirelli, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5510-07.2008 · Cited by 300
Molecular basis of plasticity in the visual cortex
Berardi, N., Pizzorusso, T., Ratto, G. M., & Maffei, L. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00168-1 · Cited by 294
Brain Gene Expression During REM Sleep Depends on Prior Waking ExperiencePreprint
Ribeiro, S. T. G., Goyal, V., Mello, C. V., & Pavlides, C. (1999) · Learning & Memory · doi:10.1101/lm.6.5.500 · Cited by 264
Visual Deprivation Reactivates Rapid Ocular Dominance Plasticity in Adult Visual Cortex
He, H., Hodos, W., & Quinlan, E. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5554-05.2006 · Cited by 263
Ribeiro, S. T. G., Mello, C. V., Velho, T., Gardner, T. J., Jarvis, E. D., & Pavlides, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10914.2002 · Cited by 250
The critical period for ocular dominance plasticity in the Ferret's visual cortex
Issa, N. P., Trachtenberg, J. T., Chapman, B., Zahs, K. R., & Stryker, M. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06965.1999 · Cited by 243
Exploratory Behavior, Cortical BDNF Expression, and Sleep Homeostasis
Huber, R., Tononi, G., & Cirelli, C. (2007) · Sleep · doi:10.1093/sleep/30.2.129 · Cited by 224
LTP consolidation: Substrates, explanatory power, and functional significance
Lynch, G., Rex, C. S., & Gall, C. M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.027 · Cited by 214
Molecular and systems mechanisms of memory consolidation and storage
Wang, H., Hu, Y., & Tsien, J. Z. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.004 · Cited by 214
Tartar, J. L., Ward, C. P., McKenna, J. T., Thakkar, M., Arrigoni, E., McCarley, R. W., Brown, R. E., & Strecker, R. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04808.x · Cited by 206
Rauschecker, J. P., & Hahn, S. (1987) · Nature · doi:10.1038/326183a0 · Cited by 202
Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
Kopp, C., Longordo, F., Nicholson, J. R., & Lüthi, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-06.2006 · Cited by 192
McDermott, C. M., Hardy, M. N., Bazan, N. G., & Magee, J. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093781 · Cited by 178
Mioche, L., & Singer, W. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.1.185 · Cited by 177
Albensi, B. C., Oliver, D. R., Toupin, J. D., & Odero, G. L. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.009 · Cited by 176
The Role of Sleep in Memory Consolidation and Brain Plasticity: Dream or Reality?
Frank, M. G., & Benington, J. H. (2006) · The Neuroscientist · doi:10.1177/1073858406293552 · Cited by 143
Lifelong learning: ocular dominance plasticity in mouse visual cortex
Hofer, S. B., Mrsic‐Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.06.007 · Cited by 142
Uetsuki, T., Takemoto, K., Nishimura, I., Okamoto, M., Niinobe, M., Momoi, T., Miura, M., & Yoshikawa, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06955.1999 · Cited by 131
Role of Ca2+‐stimulated adenylyl cyclases in LTP and memory formation
Poser, S., & Storm, D. R. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00094-0 · Cited by 128
Chen, C., Hardy, M., Zhang, J., LaHoste, G. J., & Bazan, N. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.021 · Cited by 110
Sleep-Dependent Plasticity Requires Cortical Activity
Jha, S. K., Jones, B. E., Coleman, T., Steinmetz, N., Law, C.-T., Griffin, G., Hawk, J., Dabbish, N., Kalatsky, V. A., & Frank, M. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2722-05.2005 · Cited by 96
Kaneko, M., Hanover, J. L., England, P. M., & Stryker, M. P. (2008) · Nature Neuroscience · doi:10.1038/nn2068 · Cited by 91
Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex
Beaver, C. J., Ji, Q., Fischer, Q. S., & Daw, N. W. (2001) · Nature Neuroscience · doi:10.1038/83985 · Cited by 85
Liao, D. S., Krahe, T. E., Prusky, G. T., Medina, A. E., & Ramoa, A. S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00266.2004 · Cited by 73
The Non-Benzodiazepine Hypnotic Zolpidem Impairs Sleep-Dependent Cortical Plasticity
(2008) · Sleep · doi:10.5665/sleep/31.10.1381 · Cited by 60
Effects of NMDA antagonists on developmental plasticity in kitten visual cortex
Rauschecker, J. P., Egert, U., & Kossel, A. H. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90075-d · Cited by 47
Visual–Procedural Memory Consolidation during Sleep Blocked by Glutamatergic Receptor Antagonists
Gais, S., Rasch, B., Wagner, U., & Born, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5374-07.2008 · Cited by 47
Hardingham, N. R., Wright, N. F., Dachtler, J., & Fox, K. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.018 · Cited by 46
Blockade of postsynaptic activity in sleep inhibits developmental plasticity in visual cortex
Frank, M. G., Jha, S. K., & Coleman, T. (2006) · NeuroReport · doi:10.1097/01.wnr.0000233100.05408.e4 · Cited by 33
Self-citationSnapShot: Ca2+-Dependent Transcription in Neurons
Zieg, J., Greer, P. L., & Greenberg, M. E. (2008) · Cell · doi:10.1016/j.cell.2008.09.010 · Cited by 21
Sleep does not enhance the recovery of deprived eye responses in developing visual cortex
Dadvand, L., Stryker, M. P., & Frank, M. G. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.029 · Cited by 17
Cnops, L., Hu, T., Burnat, K., & Arckens, L. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm157 · Cited by 14
Orientation Selectivity Is Reduced by Monocular Deprivation in Combination With PKA Inhibitors
Beaver, C. J., Fischer, Q. S., Ji, Q., & Daw, N. W. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.4.1933 · Cited by 10
Effects of brief uniocular 'patching' on kitten visual cortex.
Freeman, R. D. (1979) · PubMed · Cited by 7
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Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“The beneficial effect of sleep on consolidation of ODP mainly leads to a strengthening of the cortical responses to stimulation of the nondeprived eye (48).”
BackgroundInfluentialTononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740
Metadata
- Authors
- Aton, S. J., Seibt, J., Dumoulin, M., Jha, S. K., Steinmetz, N., Coleman, T., Naidoo, N., & Frank, M. G.
- Affiliations
- University of Pennsylvania (US)
- Jawaharlal Nehru University (IN)
- Corresponding author
- Frank, Marcos G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 61
- Issue
- 3
- Pages
- 454-466
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2665998
- OpenAlex
- W2161849272
- Cited by
- 244
- References
- 58
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 17 · 2021: 11 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 20 · 2016: 13 · 2015: 12 · 2014: 18 · 2013: 21 · 2012: 15
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Eye Institute (F32EY006831, R01EY019022, F32EY017766)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ocular dominance plasticity, monocular deprivation, NMDA receptor, protein kinase A, synaptic plasticity, glutamatergic synapses, synaptic potentiation, cortical plasticity, protein phosphorylation
- MeSH terms
- Animals, Cats, Cerebral Cortex, Enzyme Inhibitors, Learning, Synaptic Transmission, Neuronal Plasticity, Phosphorylation, Photic Stimulation, Sensory Deprivation, Sleep, Synapses, Receptors, N-Methyl-D-Aspartate, Cyclic AMP-Dependent Protein Kinases, Excitatory Amino Acid Antagonists, Glutamic Acid
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