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Functions and Dysfunctions of Adult Hippocampal Neurogenesis
Abstract
Adult neurogenesis, a developmental process of generating functionally integrated neurons, occurs throughout life in the hippocampus of the mammalian brain and showcases the highly plastic nature of the mature central nervous system. Significant progress has been made in recent years to decipher how adult neurogenesis contributes to brain functions. Here we review recent findings that inform our understanding of adult hippocampal neurogenesis processes and special properties of adult-born neurons. We further discuss potential roles of adult-born neurons at the circuitry and behavioral levels in cognitive and affective functions and how their dysfunction may contribute to various brain disorders. We end by considering a general model proposing that adult neurogenesis is not a cell-replacement mechanism, but instead maintains a plastic hippocampal neuronal circuit via the continuous addition of immature, new neurons with unique properties and structural plasticity of mature neurons induced by new-neuron integration.
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“Remarkably, TAC treatment induced a significant increase in the expression of genes positively associated with adult hippocampus neurogenesis and brain function,30–35 including Eomes, a driver of immune cell development & neurogenesis, Dlk1, a mediator of adult hippocampal neurogenesis and cognition, Gdnf, a neurotrophic factor, Dcx, a marker for new-born neurons, Sox1/2, critical determinants of”
From TERT activation targets DNA methylation and multiple aging hallmarks (2024) · cites this paper as [30]
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Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
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“Future studies of newborn neurons in vivo, such as targeted recording of firing properties (Leutgeb et al. 2007; Neunuebel & Knierim 2012, 2014) or calcium imaging using miniature microscopes (Ziv et al. 2013), will provide essential new information and significantly advance the field.”
BackgroundIncreasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
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Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206
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Self-citation
Metadata
- Authors
- Christian, K. M., Song, H., & Ming, G.-L.
- Affiliations
- Institute for Cell Engineering,
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2014-07-08
- Volume
- 37
- Issue
- 1
- Pages
- 243-262
- ISSN
- 0147-006X
- 1545-4126
- PMC
- PMC5531058
- Cited by
- 362
- References
- 21
- Language
- en
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