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Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses
Open accessAbstract
This review describes unique neuromodulatory influences on working memory prefrontal cortical (PFC) circuits that coordinate cognitive strength with arousal state. Working memory arises from recurrent excitation within layer III PFC pyramidal cell NMDA circuits, which are afflicted in aging and schizophrenia. Neuromodulators rapidly and flexibly alter the efficacy of these synaptic connections, while leaving the synaptic architecture unchanged, a process called dynamic network connectivity (DNC). Increases in calcium-cAMP signaling open ion channels in long, thin spines, gating network connections. Inhibition of calcium-cAMP signaling by stimulating α2A-adrenoceptors on spines strengthens synaptic efficacy and increases network firing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental representation. Generalized increases in calcium-cAMP signaling during fatigue or stress disengage dlPFC recurrent circuits, reduce firing and impair top-down cognition. Impaired DNC regulation contributes to age-related cognitive decline, while genetic insults to DNC proteins are commonly linked to schizophrenia.
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“Immunoelectron microscopy studies of human126 and rhesus monkey13,127 dlPFC show that DISC1 is located in layer III spines, where it anchors PDE4A next to the spine apparatus, critically positioned to regulate feedforward cAMP–Ca2+ stress signaling pathways13,127.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
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“Exposure to stress, however, can disrupt PFC function, markedly impairing working memory (Arnsten, 2009; Arnsten et al., 2012).”
From Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex (2013) · cites this paper as Arnsten et al., 2012
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“In these circuits, cAMP-PKA signaling opens nearby potassium (K+) channels to rapidly weaken synaptic strength and reduce Delay cell firing (Fig. 3C; (Arnsten et al., 2012)).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Arnsten et al., 2012
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“Layer III dlPFC microcircuits that generate mental representations have unique molecular needs for both neurotransmission and neuromodulation that allow them to sustain long periods of neuronal firing without bottom-up sensory stimulation (Arnsten, 2015, Arnsten et al., 2012).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Arnsten et al., 2012
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“These very rapid changes in synapse strength, called dynamic network connectivity13, are mediated by feedforward, cAMP–Ca2+ signaling, which opens K+ channels (HCN, KCNQ) near the synapse to weaken the connection.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
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“Physiological, behavioral and immunoelectron microscopic evidence suggest that these pathways interact: feedforward Ca2+–cAMP signaling opens nearby HCN and KCNQ K+ channels to weaken the efficacy of nearby NMDAR synaptic connections13.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [13]
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“Pharmacological investigations indicate that this relationship depends upon the level of release of neuromodulators, such as dopamine and norepinephrine (Arnsten, 2009; Arnsten et al., 2012).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
In the citing paper
“Activation of receptors for these neuromodulators at intermediate levels may enhance performance on PFC dependent tasks, whereas further increases may result in a decrement in behavioral performance and reduced neural representation of that performance in the PFC (reviewed in (Arnsten, 2009; Arnsten et al., 2012)).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
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“In tasks that require prefrontal cortical (PFC) function, there is an inverted U relationship between stress and performance.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Arnsten et al., 2012
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Citations
Cites
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Receptive fields of single neurones in the cat's striate cortex
Hubel, D. H., & Wiesel, T. N. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006308 · Cited by 4,653
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
Self-citationMnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
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- Jacobsen, 1936, Studies of cerebral function in primates, Comp. Psychol. Monogr., 13, 1
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Sorted by citations
The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.002 · Cited by 938
Orienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056
Dynamic adaptation of large-scale brain networks in response to acute stressors
Hermans, E. J., Henckens, M. J. A. G., Joëls, M., & Fernández, G. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.006 · Cited by 988
Waking state: rapid variations modulate neural and behavioral responses
McGinley, M. J., Vinck, M., Reimer, J., Batista-Brito, R., Zagha, E., Cadwell, C. R., Tolias, A. S., Cardin, J. A., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.012 · Cited by 801
“Pharmacological investigations indicate that this relationship depends upon the level of release of neuromodulators, such as dopamine and norepinephrine (Arnsten, 2009; Arnsten et al., 2012).”
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752
Self-citationDopamine and Cognitive Control in Prefrontal Cortex
Ott, T., & Nieder, A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.006 · Cited by 530
Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489
Self-citationLogue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477
Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
Speranza, L., di Porzio, U., Viggiano, D., Donato, A. D., & Volpicelli, F. (2021) · Cells · doi:10.3390/cells10040735 · Cited by 472
Human cognitive aging: Corriger la fortune?
Lindenberger, U. (2014) · Science · doi:10.1126/science.1254403 · Cited by 414
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context
Römer, D., Reyna, V. F., & Satterthwaite, T. D. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.07.007 · Cited by 466
Arnsten, A. F. T., Raskind, M. A., Taylor, F. B., & Connor, D. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.002 · Cited by 381
Self-citationHassani, S. A., Oemisch, M., Balcarras, M., Westendorff, S., Ardid, S., van der Meer, M. A. A., Tiesinga, P. H. E., & Womelsdorf, T. (2017) · Scientific Reports · doi:10.1038/srep40606 · Cited by 364
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350
Medial prefrontal cortex in neurological diseases
Xu, P., Chen, A., Li, Y., Xing, X., & Lü, H. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00006.2019 · Cited by 360
Radley, J., Morilak, D., Viau, V., & Campeau, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.018 · Cited by 339
Neuromodulation of brain state and behavior
McCormick, D. A., Nestvogel, D. B., & He, B. J. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-105424 · Cited by 303
Cognitive emotion regulation fails the stress test
Raio, C. M., Orederu, T. A., Palazzolo, L., Shurick, A. A., & Phelps, E. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305706110 · Cited by 302
Persistent Spiking Activity Underlies Working Memory
Constantinidis, C., Funahashi, S., Lee, D., Murray, J. D., Qi, X.-L., Wang, M., & Arnsten, A. F. T. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2486-17.2018 · Cited by 295
Self-citationMcKlveen, J. M., Myers, B., & Herman, J. P. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12272 · Cited by 273
Activation of Corticostriatal Circuitry Relieves Chronic Neuropathic Pain
Lee, M., Manders, T. R., Eberle, S. E., Su, C. H., D’amour, J. A., Yang, R., Lin, H. Y., Deisseroth, K. A., Froemke, R. C., & Wang, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3494-14.2015 · Cited by 261
A Neuroergonomics Approach to Mental Workload, Engagement and Human Performance
Dehais, F., Lafont, A., Roy, R. N., & Fairclough, S. H. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00268 · Cited by 296
Hara, Y., Yuk, F., Puri, R., Janssen, W. G. M., Rapp, P. R., & Morrison, J. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311310110 · Cited by 244
Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments
Avery, M. C., & Krichmar, J. L. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00108 · Cited by 250
Developmental origins of brain disorders: roles for dopamine
Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221
Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
Ranjbar‐Slamloo, Y., & Fazlali, Z. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00334 · Cited by 241
Benarroch, E. E. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2649-1 · Cited by 218
Ross, J. A., & Bockstaele, E. J. V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.601519 · Cited by 241
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex
Shansky, R. M., & Lipps, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00123 · Cited by 205
“Adapted from Arnsten (2009) and Arnsten et al. (2012).”
BackgroundCools, R., & Arnsten, A. F. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01100-8 · Cited by 216
Self-citationMolecular aspects of age-related cognitive decline: the role of GABA signaling
McQuail, J. A., Frazier, C. J., & Bizon, J. L. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.05.002 · Cited by 207
Xing, B., Li, Y.-C., & Gao, W.-J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.01.005 · Cited by 196
Layer-dependent activity in human prefrontal cortex during working memory
Finn, E. S., Huber, L., Jangraw, D. C., Molfese, P. J., & Bandettini, P. A. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0487-z · Cited by 192
Zagha, E., & McCormick, D. A. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.010 · Cited by 191
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang, Y., Paspalas, C. D., Jin, L. E., Picciotto, M. R., Arnsten, A. F. T., & Wang, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307849110 · Cited by 188
Self-citationPuig, M. V., Rose, J., Schmidt, R., & Freund, N. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00093 · Cited by 207
Klauss, J., Penido Pinheiro, L. C., Silva Merlo, B. L., Correia Santos, G. D. A., Fregni, F., Nitsche, M. A., & Miyuki Nakamura-Palacios, E. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000984 · Cited by 178
Arion, D., Corradi, J. P., Tang, S., Datta, D., Boothe, F., He, A., Cacace, A. M., Zaczek, R., Albright, C. F., Tseng, G., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.171 · Cited by 177
Prefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176
Maletic, V., Eramo, A., Gwin, K., Offord, S. J., & Duffy, R. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00042 · Cited by 184
Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 179
Decision Making: From Neuroscience to Psychiatry
Lee, D. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.008 · Cited by 178
Nyberg, L. H., Karalija, N., Salami, A., Andersson, M., Wåhlin, A., Kaboodvand, N., Köhncke, Y., Axelsson, J., Rieckmann, A., Papenberg, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606309113 · Cited by 164
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.
Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress · doi:10.1177/24705470211029254 · Cited by 159
Self-citationMenon, B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109385 · Cited by 154
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149
Self-citationChemistry of the Adaptive Mind: Lessons from Dopamine
Cools, R. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.035 · Cited by 150
Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?
Atzori, M., Cuevas‐Olguin, R., Esquivel‐Rendon, E., García‐Oscos, F., Salgado‐Delgado, R., Saderi, N., Miranda‐Morales, M., Treviño, M., Pineda, J. C., & Salgado, H. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00025 · Cited by 156
Ventura‐Bort, C., Wirkner, J., Genheimer, H., Wendt, J., Hamm, A. O., & Weymar, M. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00202 · Cited by 147
Increases in Functional Connectivity between Prefrontal Cortex and Striatum during Category Learning
Antzoulatos, E. G., & Miller, E. K. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.005 · Cited by 150
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams, T. G., Kelmendi, B., Brake, C. A., Gruner, P., Badour, C. L., & Pittenger, C. (2018) · Chronic Stress · doi:10.1177/2470547018758043 · Cited by 154
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology
Paspalas, C. D., Carlyle, B. C., Leslie, S., Preuss, T. M., Crimins, J. L., Huttner, A. J., van Dyck, C. H., Rosene, D. L., Nairn, A. C., & Arnsten, A. F. T. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.005 · Cited by 140
Self-citationcAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322360111 · Cited by 139
Self-citationPrefrontal dopamine in associative learning and memory
Puig, M. V., Antzoulatos, E. G., & Miller, E. K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.026 · Cited by 148
Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex
Wallace, T. L., & Bertrand, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.001 · Cited by 133
The costs and benefits of brain dopamine for cognitive control
Cools, R. (2016) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1401 · Cited by 164
Mechanisms of Working Memory Impairment in Schizophrenia
Van Snellenberg, J. X., Girgis, R. R., Horga, G., van de Giessen, E., Slifstein, M., Ojeil, N., Weinstein, J. J., Moore, H., Lieberman, J. A., Shohamy, D., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.017 · Cited by 123
Ma, Q., Tang, Y., Wang, F., Liao, X., Jiang, X., Wei, S., Mechelli, A., Yong He, A., & Xia, M. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz111 · Cited by 119
Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?
Yan, Z., Kim, E., Datta, D., Lewis, D. A., & Soderling, S. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2360-16.2016 · Cited by 120
Santello, M., & Nevian, T. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.003 · Cited by 118
Stress effects on the neural substrates of motivated behavior
Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 129
Su, H., Zhong, N., Gan, H., Wang, J., Han, H., Chen, T., Li, X., Ruan, X., Zhu, Y., Jiang, H., et al. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.037 · Cited by 116
Rey, C. D., Lipps, J., & Shansky, R. M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.338 · Cited by 123
A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex
Froudist‐Walsh, S., Bliss, D. P., Ding, X., Rapan, L., Niu, M., Knoblauch, K., Zilles, K., Kennedy, H., Palomero‐Gallagher, N., & Wang, X. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.024 · Cited by 122
Berridge, C. W., & Spencer, R. C. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.024 · Cited by 112
Hoftman, G. D., Datta, D., & Lewis, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.022 · Cited by 113
Jin, L. E., Wang, M., Galvin, V. C., Lightbourne, T. C., Conn, P. J., Arnsten, A. F. T., & Paspalas, C. D. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx005 · Cited by 112
Self-citationRole of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108
Genetic dissection of GABAergic neural circuits in mouse neocortex
Taniguchi, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00008 · Cited by 106
Psychostimulants and motivated behavior: Arousal and cognition
Berridge, C. W., & Arnsten, A. F. T. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.005 · Cited by 104
Self-citationTan, T., Wang, W., Liu, T., Zhong, P., Conrow‐Graham, M., Tian, X., & Yan, Z. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108874 · Cited by 104
Connor, D. F., Grasso, D. J., Slivinsky, M. D., Pearson, G. S., & Banga, A. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0119 · Cited by 102
Antisaccade task reflects cortical involvement in mild cognitive impairment
Heuer, H. W., Mirsky, J. B., Kong, E. L., Dickerson, B. C., Miller, B. L., Kramer, J. H., & Boxer, A. L. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a6cbfe · Cited by 108
Catecholamines and cognition after traumatic brain injury
Jenkins, P. O., Mehta, M. A., & Sharp, D. J. (2016) · Brain · doi:10.1093/brain/aww128 · Cited by 102
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Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94
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Mäki-Marttunen, V., Andreassen, O. A., & Espeseth, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.038 · Cited by 100
EEG coherence in theta, alpha, and beta bands in frontal regions and executive functions
Basharpoor, S., Heidari, F., & Molavi, P. (2019) · Applied Neuropsychology Adult · doi:10.1080/23279095.2019.1632860 · Cited by 99
Datta, D., Arion, D., Corradi, J., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.030 · Cited by 93
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Metadata
- Authors
- Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D.
- Affiliations
- Yale University (US)
- Corresponding author
- Arnsten, Amy F.T.
- ORCID
- Arnsten, Amy F.T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 76
- Issue
- 1
- Pages
- 223-239
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3488343
- OpenAlex
- W2087809804
- Cited by
- 538
- References
- 168
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 27 · 2023: 56 · 2022: 30 · 2021: 47 · 2020: 39 · 2019: 28 · 2018: 39 · 2017: 32 · 2016: 41 · 2015: 58 · 2014: 42 · 2013: 38 · 2012: 3
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Yale University
- National Alliance for Research on Schizophrenia and Depression
- Zorginstituut Nederland
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (RL1AA017536)
- National Institute on Aging (P01AG030004)
- National Institute of Mental Health (MH 09335401, R01MH093354)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuromodulation, working memory, prefrontal cortex, NMDA receptor, dendritic spines, alpha2A-adrenoceptor, dopamine D1 receptor, recurrent excitation, aging, schizophrenia, fatigue, stress
- MeSH terms
- Animals, Humans, Nerve Net, Synaptic Transmission, Synapses, Thinking, Prefrontal Cortex, Neurotransmitter Agents
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