Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
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- Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tauRayaprolu, Sruti, Higginbotham, Lenora, Bagchi, Pritha, Watson, Caroline M., Zhang, Tian, Levey, Allan I., Rangaraju, Srikant, Seyfried, Nicholas T. · 2021 · Neuropsychopharmacology
- Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissueHardwick, Simon A., Hu, Wen, Joglekar, Anoushka, Fan, Li, Collier, Paul G., Foord, Careen, Balacco, Jennifer, Lanjewar, Samantha, Sampson, Maureen McGuirk, Koopmans, Frank et al. · 2022 · Nature Biotechnology
- Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autismRamaswami, Gokul, Won, Hyejung, Gandal, Michael J., Haney, Jillian, Wang, Jerry C., Wong, Chloe C. Y., Sun, Wenjie, Prabhakar, Shyam, Mill, Jonathan, Geschwind, Daniel H. · 2020 · Nature Communications
- ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African AmericansConway, Olivia J, Carrasquillo, Minerva M, Wang, Xue, Bredenberg, Jenny M, Reddy, Joseph S, Strickland, Samantha L, Younkin, Curtis S, Burgess, Jeremy D, Allen, Mariet, Lincoln, Sarah J et al. · 2018 · Molecular Neurodegeneration
- Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disordersCaruso, Giuseppe, Caraci, Filippo, Jolivet, Renaud B. · 2019 · Progress in Neurobiology
- Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s diseaseWestern, Daniel, Timsina, Jigyasha, Wang, Lihua, Wang, Ciyang, Yang, Chengran, Phillips, Bridget, Wang, Yueyao, Liu, Menghan, Ali, Muhammad, Beric, Aleksandra et al. · 2024 · Nature Genetics
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- APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytesde Leeuw, Sherida M., Kirschner, Aron W.T., Lindner, Karina, Rust, Ruslan, Budny, Vanessa, Wolski, Witold E., Gavin, Anne-Claude, Nitsch, Roger M., Tackenberg, Christian · 2022 · Stem Cell Reports
- iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel ScaffoldsFaley, Shannon L., Neal, Emma H., Wang, Jason X., Bosworth, Allison M., Weber, Callie M., Balotin, Kylie M., Lippmann, Ethan S., Bellan, Leon M. · 2019 · Stem Cell Reports
- Glia in neurodegeneration: Drivers of disease or along for the ride?Gleichman, Amy J., Carmichael, S. Thomas · 2020 · Neurobiology of Disease
- A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s diseaseTsartsalis, Stergios, Sleven, Hannah, Fancy, Nurun, Wessely, Frank, Smith, Amy M., Willumsen, Nanet, Cheung, To Ka Dorcas, Rokicki, Michal J., Chau, Vicky, Ifie, Eseoghene et al. · 2024 · Nature Communications
- VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseasesBorggrewe, Malte, Grit, Corien, Den Dunnen, Wilfred F. A., Burm, Saskia M., Bajramovic, Jeffrey J., Noelle, Randolph J., Eggen, Bart J. L., Laman, Jon D. · 2018 · Glia
- Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s diseaseZhou, Maotian, Haque, Rafi U., Dammer, Eric B., Duong, Duc M., Ping, Lingyan, Johnson, Erik C. B., Lah, James J., Levey, Allan I., Seyfried, Nicholas T. · 2020 · Clinical Proteomics
- The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's diseaseMoutinho, Miguel, Puntambekar, Shweta S., Tsai, Andy P., Coronel, Israel, Lin, Peter B., Casali, Brad T., Martinez, Pablo, Oblak, Adrian L., Lasagna-Reeves, Cristian A., Lamb, Bruce T. et al. · 2022 · Science Translational Medicine
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- A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s diseasePatir, Anirudh, Shih, Barbara, McColl, Barry W., Freeman, Tom C. · 2019 · Glia
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- Shifting paradigms: The central role of microglia in Alzheimer’s diseaseSchwabe, Tina, Srinivasan, Karpagam, Rhinn, Herve · 2020 · Neurobiology of Disease
- Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathyChadarevian, Jean Paul, Hasselmann, Jonathan, Lahian, Alina, Capocchi, Joia K., Escobar, Adrian, Lim, Tau En, Le, Lauren, Tu, Christina, Nguyen, Jasmine, Kiani Shabestari, Sepideh et al. · 2024 · Neuron
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- DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytesGiordano, Anna Maria Sole, Luciani, Marco, Gatto, Francesca, Abou Alezz, Monah, Beghè, Chiara, Della Volpe, Lucrezia, Migliara, Alessandro, Valsoni, Sara, Genua, Marco, Dzieciatkowska, Monika et al. · 2022 · Journal of Experimental Medicine
- Identification of Conserved Proteomic Networks in Neurodegenerative DementiaSwarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Dai, Jingting, Lah, James J., Johnson, Erik C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2020 · Cell Reports
- Identification of conserved proteomic networks in neurodegenerative dementiaSwarup, Vivek, Chang, Timothy S., Duong, Duc M., Dammer, Eric B., Lah, James J., Johnson, Erik E.C.B., Seyfried, Nicholas T., Levey, Allan I., Geschwind, Daniel H. · 2019
- Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathologySimon, Matthew J., Wang, Marie X., Murchison, Charles F., Roese, Natalie E., Boespflug, Erin L., Woltjer, Randall L., Iliff, Jeffrey J. · 2018 · Scientific Reports
- What are activated and reactive glia and what is their role in neurodegeneration?Bennett, Mariko L., Viaene, Angela N. · 2021 · Neurobiology of Disease
- Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's diseaseCastranio, Emilie L., Hasel, Philip, Haure‐Mirande, Jean‐Vianney, Ramirez Jimenez, Angie V., Hamilton, B. Wade, Kim, Rachel D., Glabe, Charles G., Wang, Minghui, Zhang, Bin, Gandy, Sam et al. · 2023 · Alzheimer's & Dementia
- Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterolCashikar, Anil G., Toral-Rios, Danira, Timm, David, Romero, Johnathan, Strickland, Michael, Long, Justin M., Han, Xianlin, Holtzman, David M., Paul, Steven M. · 2023 · Journal of Lipid Research
- GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementiaShade, Lincoln M. P., Katsumata, Yuriko, Abner, Erin L., Aung, Khine Zin, Claas, Steven A., Qiao, Qi, Heberle, Bernardo Aguzzoli, Brandon, J. Anthony, Page, Madeline L., Hohman, Timothy J. et al. · 2024 · Nature Genetics
- Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampusMuñoz-Castro, Clara, Mejias-Ortega, Marina, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Trujillo-Estrada, Laura, Jimenez, Sebastian, Garcia-Leon, Juan Antonio, Fernandez-Valenzuela, Juan Jose, Sanchez-Mico, Maria Virtudes, Romero-Molina, Carmen et al. · 2023 · Acta Neuropathologica Communications
- Metabolic reprogramming of astrocytes in pathological conditions: implications for neurodegenerative diseasesCalì, Corrado, Cantando, Iva, Veloz Castillo, Maria Fernanda, Gonzalez, Laurine, Bezzi, Paola · 2024 · International Journal of Molecular Sciences
- RAB10: an Alzheimer’s disease resilience locus and potential drug targetTavana, Justina, Rosene, Matthew, Jensen, Nick, Ridge, Perry G., Kauwe, John S.K., Karch, Celeste M. · 2018 · Clinical Interventions in Aging
- Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuumAli, Muhammad, Timsina, Jigyasha, Western, Daniel, Liu, Menghan, Beric, Aleksandra, Budde, John, Do, Anh, Heo, Gyujin, Wang, Lihua, Gentsch, Jen et al. · 2025 · Neuron
- The highly pleiotropic gene SLC39A8 as an opportunity to gain insight into the molecular pathogenesis of schizophreniaCostas, Javier · 2018 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Chemical compound-based direct reprogramming for future clinical applications.Takeda, Yukimasa, Harada, Yoshinori, Yoshikawa, Toshikazu, Dai, Ping · 2018 · Bioscience Reports
- Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s diseaseMorshed, Nader, Lee, Meelim J., Rodriguez, Felicia H., Lauffenburger, Douglas A., Mastroeni, Diego, White, Forest M. · 2021 · Nature Aging
- Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell ModelMizuno, Grace O., Wang, Yinxue, Shi, Guilai, Wang, Yizhi, Sun, Junqing, Papadopoulos, Stelios, Broussard, Gerard J., Unger, Elizabeth K., Deng, Wenbin, Weick, Jason et al. · 2018 · Cell Reports
- Astrocyte-specific transcriptome responses to chronic ethanol consumptionErickson, Emma K., Farris, Sean P., Blednov, Yuri A., Mayfield, R. Dayne, Harris, R. Adron · 2018 · The Pharmacogenomics Journal
- Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s diseaseRajani, Rikesh M., Ellingford, Robert, Hellmuth, Mariam, Harris, Samuel S., Taso, Orjona S., Graykowski, David, Lam, Francesca Kar Wey, Arber, Charles, Fertan, Emre, Danial, John S. H. et al. · 2024 · PLOS Biology
- Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structureThe Dominantly Inherited Alzheimer Network (DIAN), Li, Zeran, Del-Aguila, Jorge L., Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J., Dougherty, Joseph D. et al. · 2018 · Genome Medicine
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- Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's DiseaseChiarini, Anna, Armato, Ubaldo, Liu, Daisong, Dal Prà, Ilaria · 2016 · Frontiers in Physiology
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- CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse modelJohnson, Noah R., Yuan, Peng, Castillo, Erika, Lopez, T. Peter, Yue, Weizhou, Bond, Annalise, Rivera, Brianna M., Sullivan, Miranda C., Hirouchi, Masakazu, Giles, Kurt et al. · 2023 · Nature Communications
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- Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?Staurenghi, Erica, Giannelli, Serena, Testa, Gabriella, Sottero, Barbara, Leonarduzzi, Gabriella, Gamba, Paola · 2021 · Antioxidants
- Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s diseaseHuang, Yong, Wang, Minghui, Ni, Haofei, Zhang, Jinglong, Li, Aiqun, Hu, Bin, Junqueira Alves, Chrystian, Wahane, Shalaka, Rios de Anda, Mitzy, Ho, Lap et al. · 2024 · Nature Neuroscience
- Microglia‐specific ApoE knock‐out does not alter Alzheimer's disease plaque pathogenesis or gene expressionHenningfield, Caden M., Arreola, Miguel A., Soni, Neelakshi, Spangenberg, Elizabeth E., Green, Kim N. · 2022 · Glia
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- CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruningTeter, Olivia M., McQuade, Amanda, Hagan, Venus, Liang, Weiwei, Dräger, Nina M., Sattler, Sydney M., Holmes, Brandon B., Castillo, Vincent Cele, Papakis, Vasileios, Leng, Kun et al. · 2025 · Molecular Psychiatry
- Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking AlterationsRivero-Ríos, Pilar, Romo-Lozano, Maria, Fernández, Belén, Fdez, Elena, Hilfiker, Sabine · 2020 · Cells
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- A new diagnostic tool for brain disorders: extracellular vesicles derived from neuron, astrocyte, and oligodendrocyteWang, Xueying, Yang, Huihui, Liu, Chunyu, Liu, Kefu · 2023 · Frontiers in Molecular Neuroscience
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- The Alzheimer's Disease Gene SORL1 Regulates Lysosome Function in Human MicrogliaMishra, Swati, Morshed, Nader, Sidhu, Sonia Beant, Kinoshita, Chizuru, Stevens, Beth, Jayadev, Suman, Young, Jessica E. · 2025 · Glia
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